Medicament composition for treating tinea corporis and preparation method of medicament composition

A composition and drug technology, applied in the field of medicine, can solve the problems of large side effects, easy recurrence, long treatment cycle, etc., and achieve good biological activity, quick effect, and short treatment period

Inactive Publication Date: 2015-04-08
李健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine treatment mostly adopts chemical preparations, such as hormonal drugs, which have quick effects, but have large side effects and are prone to relapse; while exis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Preparation of Ghost needle grass extract

[0013] Weigh 1kg of fresh root of Ghost needle grass, colloidal grinding treatment, add 1L of phosphate buffer solution (pH 7.2) to the obtained slurry, stir and extract in a water bath at 50°C for 24 hours, filter with four layers of gauze , the filter residue was discarded, and the obtained filtrate was subjected to vacuum rotary evaporation and freeze-drying to obtain 72.5 g of solid, which was ground into a fine powder and passed through a 100-mesh sieve to obtain the extract of Ghost needles. Preparation of phosphate buffer (pH 7.2): Take 250ml of 0.2mol / L potassium dihydrogen phosphate solution and 175ml of 0.2mol / L sodium hydroxide solution, add freshly boiled cold water to dilute to 1L, shake well to get ready.

Embodiment 2

[0014] The preparation of embodiment 2 ointment

[0015] prescription:

[0016] Extract 10g

[0017] Urea 50g

[0018] Carboxymethylcellulose 40g

[0019] Glycerol 200ml

[0020] Propylene glycol 50 ml

[0021] Ethylparaben 2g

[0022] Add water to 1000g

[0023] Preparation process: Dissolve the dry powder of ghost needle grass extract prepared in Example 1 in an appropriate amount of water until the ghost needle grass extract is completely dissolved, then mix carboxymethyl cellulose with propylene glycol and glycerol, Add it into the extract liquid obtained above, stir and mix it evenly, let it swell into a gel, then add it into the aqueous solution containing urea and ethylparaben, and add water to a sufficient amount.

Embodiment 3

[0024] The preparation of embodiment 3 ointment

[0025] prescription:

[0026] Extract 20g

[0027] Urea 50g

[0028] Carboxymethylcellulose 40g

[0029] Glycerol 200ml

[0030] Propylene glycol 50 ml

[0031] Ethylparaben 2g

[0032] Add water to 1000g

[0033] Preparation process: Dissolve the dry powder of ghost needle grass extract prepared in Example 1 in an appropriate amount of water until the ghost needle grass extract is completely dissolved, then mix carboxymethyl cellulose with propylene glycol and glycerol, Add it into the extract liquid obtained above, stir and mix it evenly, let it swell into a gel, then add it into the aqueous solution containing urea and ethylparaben, and add water to a sufficient amount.

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PUM

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Abstract

The invention discloses a medicament composition for treating tinea corporis and a preparation method of the medicament composition. The medicament composition is prepared from an active component and pharmaceutically acceptable adjuncts, wherein the active component is a phosphate buffer solution educt of a spanishneedles herb raw material. As being prepared by extracting a single traditional Chinese medicine, the medicament composition is small in flavour, achieves effect and has the advantages of short course of treatment, fast effect, good curative effect and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating tinea corporis and a preparation method thereof. Background technique [0002] Tinea corporis is a superficial fungal infection of smooth skin other than the hands, feet, perineum, and thighs caused by dermatophytes. After the germs invade the epidermis, they usually only parasitize the stratum corneum, so they only cause a mild inflammatory reaction locally. At first, they are red papules or small blisters, and then form scales, and then gradually expand to the surroundings. Well-circumscribed circular lesion. Moreover, the edges are mostly raised, papules and blisters are often seen, and the surface generally has no exudate. [0003] At present, there is no effective treatment or medicine for the treatment of tinea corporis. Western medicine treatment mostly adopts chemical preparations, such as hormonal drugs, which hav...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P17/00A61P31/10A61K125/00
CPCA61K36/28A61K9/0014A61K2236/15A61K2236/331A61K2236/51A61K2236/53
Inventor 李健
Owner 李健
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