Medicine for treating liver-depression and phlegm-stasis type mammary gland hyperplasia and preparation method

A technology for mammary gland hyperplasia, liver stagnation and phlegm coagulation, applied in the field of pharmacy, can solve the problems of unacceptable for patients, excessive fat intake, high price, etc., and achieve the effect of convenient administration route, wide range of drug sources and low price

Inactive Publication Date: 2015-04-08
SHANDONG PROVINCIAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 3. Human factors or bad living habits: female infertility due to advanced age, sexual life disorders, induced abortion, marital disharmony, non-breastfeeding and other reasons, resulting in normal and periodic physiological activities of the mammary glands
[0008] 4. Unreasonable dietary structure: such as high-fat and high-energy diets lead to excessive fat intake, and bad living habits such as drinking and smoking can induce breast disease
[0009] 5. Long-term use of estrogen-containing health care products and contraceptiv

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0077] When the dosage form of described medicine is honey refining pill, its preparation method may further comprise the steps:

[0078] Step 1: firstly mix Toosendan, Augusta, Cyperus cyperi, Bergamot, Lvca plum, Lathyrus lentils and Sala in the stated ratio, and distill and crystallize to obtain powder;

[0079] Step 2: Take the remaining raw materials and mix them according to the ratio, add 2-6 times the amount of 83-94% ethanol to soak for 1-2 hours, heat and extract twice, each time for 1-1.5 hours, and combine the extracts , 124-150 mesh filtration, and then ultrafiltration through an ultrafiltration column with a cut-off molecular weight of 4400-98000, and the ultrafiltrate is concentrated under reduced pressure to an extract with a relative density of 1.04 at 87°C, which becomes component 1;

[0080] Step 3: Soak the drug residue in step 2 with 4-6 times the amount of water for 1-2.5 hours, extract once, the extraction time is 1.5-2 hours, concentrate and filter to o...

Embodiment 1

[0092] Embodiment 1 honey refining pill of the present invention

[0093] Take 17g of Toosendan, 22g of August Zha, 22g of Cyperus Cyperi, 25g of Bergamot, 14g of Lvcai Mei, 15g of Lathyrus, 17g of Salozi, 22g of Curcuma, 16g of Turmeric, 25g of Salvia, 22g of C. Liuxing 30g, Frangipani 23g, Lingxiaohua 23g, Curcuma 18g, Sorrel 19g, Betel 23g, Pangolin 15g, Xintahua 7g, Hericium erinaceus 10g, Polygala 6g, Albizia Julibrissin 12g, Rock cabbage 24g, Low ground tea 25g , 14g of corrugated seeds, 18g of geranium yellow and 23g of uncaria.

[0094] Its preparation method comprises the following steps:

[0095] Step 1: firstly mix Toosendan, Augusta, Cyperus cyperi, Bergamot, Lvca plum, Lathyrus lentils and Sala in the stated ratio, and distill and crystallize to obtain powder;

[0096] Step 2: Take the remaining raw materials and mix them according to the stated ratio, add 3 times the amount of 90% ethanol to the mixture, soak for 1 hour, heat and extract twice, each time for 1 ...

Embodiment 2

[0099] Embodiment 2 Tablet of the present invention

[0100] Take 20g of Toosendan, 30g of August Zha, 31g of Rhizoma Cyperi, 32g of Bergamot, 25g of Plum, 23g of Mucuna, 20g of Salo, 25g of Curcuma, 11g of Turmeric, 38g of Salvia, 25g of C. Liuxing 20g, Frangipani 18g, Lingxiaohua 31g, Curcuma 26g, Frangipani 16g, Betel 19g, Pangolin 24g, Xintahua 11g, Hericium erinaceus 14g, Polygala 8g, Albizia Julibrissin 15g, Rock cabbage 17g, Low ground tea 27g , Corrugated seeds 20g, Geranium yellow 13g and Uncaria 18g.

[0101] Its preparation method comprises the following steps:

[0102] The first step is to mix the raw materials of the drug in proportion, add ethanol with an alcohol concentration of 90% that is 4 times the mass of the mixture, heat and reflux for 3 hours, extract, and filter to obtain the first extract; filter the obtained dregs Then add ethanol with an alcohol concentration of 95% relative to the quality of the dregs, heat and reflux for 1 hour, extract, and filt...

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Abstract

The invention discloses a medicine for treating liver-depression and phlegm-stasis type mammary gland hyperplasia and a preparation method, wherein the medicine comprises the following raw herbal materials: szechwan Chinaberry fruit, fiveleaf akebia fruit, rhizoma cyperi, fingered citron, flos mume, all grass of David vetchling, buckeye, curcuma aromatica, turmeric, the root of red-rooted salvia, trichosanthes seed, the seed of cowherb, jasminum grandiflorum, campsis grandiflora, curcuma zedoary, climbing fig, piper hancei, pangolin, ziziphora bungeana, hericium erinaceus, polygala tenuifolia, cortex albiziae, purple bergenia herb, Japanese ardisia herb, concha arcae, tabasheer, and uncaria. The medicine disclosed by the invention has the beneficial effects that the medicine has the effects of soothing liver, relieving depression, reducing phlegm and removing stasis and is mainly used for treating liver-depression and phlegm-stasis type mammary gland hyperplasia; generation and operation of qi and blood of bodies are adjusted by utilizing traditional Chinese medicine theories and paying attention to holism concepts; simultaneously, treatment based on syndrome differentiation is carried out; emphasized treatment is carried out aiming at different clinical features; the medicine is rapid to take effect, wide in medicinal source, low in cost, simple to prepare, convenient in administration route and easy for patients to accept; and thus, the medicine disclosed by the invention can be applied to clinical market popularization.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a medicine for treating hyperplasia of mammary glands of liver stagnation and phlegm coagulation type and a preparation method thereof. Background technique [0002] Mammary gland hyperplasia refers to hyperplasia of mammary gland epithelium and fibrous tissue, structural degeneration of breast tissue ducts and lobules, and progressive growth of connective tissue. It is the most common breast disease in women and should be prevented in advance. [0003] 1. Etiology: [0004] At present, the pathogenesis of mammary gland hyperplasia has not been fully clarified, and it may be related to endocrine disorders, spirit, environment and other factors. [0005] 1. Endocrine disorders: The decrease of progesterone secretion and the relative increase of estrogen are the important reasons for the onset of mammary gland hyperplasia. Such as ovarian dysplasia, irregular menstruation, t...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P15/14A61K35/36A61K35/618
CPCA61K9/2059A61K9/2068A61K9/7076A61K35/36A61K35/618A61K36/06A61K36/185A61K36/36A61K36/428A61K36/48A61K36/53A61K36/537A61K36/58A61K36/60A61K36/63A61K36/67A61K36/69A61K36/736A61K36/74A61K36/752A61K36/8905A61K36/899A61K36/9066A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 宗园媛
Owner SHANDONG PROVINCIAL HOSPITAL
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