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Effective component composition of traditional Chinese medicines for treating hyperlipemia and preparation method of composition

An effective part, hyperlipidemia technology, applied in the field of traditional Chinese medicine compositions, can solve the problems of unstable curative effect, side effects, disease rebound, etc., to achieve the effects of no toxic side effects, treatment of hyperlipidemia, and maintaining effective ingredients

Inactive Publication Date: 2015-04-22
张群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although modern medicine has a variety of lipid-lowering drugs, most of them have side effects and the curative effect is unstable
There are still many drugs that need to be taken for a long time, and the condition will rebound after stopping the drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 8g of snake slough, 15g of basil, 29g of pepper, 28g of cicadae, 10g of iberia and 10g of Polygonum indigo, grind them into coarse powder, add 12 times the amount of water, decoct 3 times, 1 hour each time; filter After the decoction, combine the filtrates, concentrate under reduced pressure to a paste with a relative concentration of 1.1, add ethanol to make the alcohol content 70%, let it stand overnight, recover ethanol, and obtain 1000ml of concentrated solution, take simple syrup, add the above concentrated solution, And use citric acid to adjust the pH to 5, add distilled water to 5000ml, stir evenly, filter and pack into 15ml glass bottles, and pack to obtain oral liquid.

[0019] This product is a brown transparent liquid, which will not become turbid within half a year, with a pH of about 5 and a total solid of about 9%.

Embodiment 2

[0021] 1000 cases of patients were observed clinically, and all patients had obvious clinical symptoms of hyperlipidemia and were diagnosed by clinicians.

[0022] Oral the oral liquid that embodiment 1 makes, every day 2 times, each 15ml. Medication time is 20 days.

[0023] After 20 days, the statistical results of patients using the oral liquid obtained in Example 1 are shown in Table 1.

[0024] Efficacy standard: markedly effective means that after treatment, the clinical symptoms basically disappear, and the serum cholesterol and triglyceride return to normal or the drop value is greater than 40mg%. The decrease of triester is below 20mg%.

[0025] Table 1

[0026] Number of cases markedly effective invalid Significant efficiency (%) 1000 999 1 99.9%

[0027] As can be seen from Table 1, the oral liquid obtained in Example 1 has special effects in the treatment of hyperlipidemia. After the traditional Chinese medicine of the invention is ma...

Embodiment 3

[0029] The oral liquid prepared in Example 1 was used to administer ICR mice with a body weight of 20-25 g, half male and half male, and the administration was continued for 90 days.

[0030] After pre-testing, the toxicity of the lotion prepared in Example 1 was very low, and the LD50 could not be measured, so the maximum daily dosage was determined for mice. The maximum dosage is 150ml / d. After 90 days, there is no case of poisoning death, and all of them are alive and healthy. This proves that the oral liquid made from the composition of the present invention will not cause toxic and side effects to the human body.

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PUM

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Abstract

The invention discloses an effective component composition of traditional Chinese medicines for treating hyperlipemia and a preparation method of the composition. The effective component composition of the traditional Chinese medicines is prepared from the following raw materials according to certain parts by weight: snake slough, radix stemonae, zanthoxylum bungeanum maxim, cordyceps sobolifera, siberian fritillary bulb and polygonum tinctorum. The effective component composition of the traditional Chinese medicines disclosed by the invention can be prepared into a medicine for treating hyperlipemia, and the composition has the effects of nourishing liver and kidney, and moistening meridian; the composition can be used for significantly treating the hyperlipemia, and the composition has the advantages of being free from toxic and side effects and high in safety.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine compositions, in particular to a composition of effective fractions of traditional Chinese medicines for treating hyperlipidemia and a preparation method thereof. Background technique [0002] Hyperlipidemia refers to that the content of one or several lipid components in human plasma exceeds the normal maximum limit. This disease occupies a very important position in nutritional and metabolic diseases, and is one of the main factors leading to atherosclerosis. It is closely related to the occurrence of hypertension, coronary heart disease and cerebrovascular disease, and is regarded as the three major factors of coronary heart disease. one. In my country, this disease is not uncommon, and its morbidity and mortality have been increasing year by year, especially among middle-aged and elderly people. The primary etiology of this disease is unknown, and there are many family and genetic...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61P3/06A61K35/64A61K35/583
CPCA61K35/583A61K9/0053A61K9/08A61K36/066A61K36/19A61K36/315A61K36/704A61K36/758A61K36/8966A61K36/904A61K47/12A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 张群
Owner 张群
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