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Recombinant human collagen vaginal gel for vaginal dryness and its preparation method

A technology of human collagen and vaginal dryness, which is applied in the direction of peptide/protein components, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of product shortage, achieve less irritation, Good biocompatibility, the effect of good biocompatibility

Active Publication Date: 2017-02-22
SHANXI JINBO BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of lack of products for female vaginal dryness, the present invention provides a recombinant human collagen vaginal gel, and the present invention also provides a preparation method of the product

Method used

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  • Recombinant human collagen vaginal gel for vaginal dryness and its preparation method
  • Recombinant human collagen vaginal gel for vaginal dryness and its preparation method
  • Recombinant human collagen vaginal gel for vaginal dryness and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0069] A recombinant human collagen vaginal gel, the ingredients include recombinant human collagen 0.05%, poloxamer 407 10%, poloxamer 188 0.5%, sodium hyaluronate 0.5%, glycerin 1%, antibacterial Preservatives: phenoxyethanol 0.1%, sodium methylparaben 1.5%, sodium propylparaben 0.01%; the balance is water.

[0070] Taking the preparation of 1kg of gel as an example, the concentration of recombinant human collagen is 0.05%, that is, every 1kg of dressing contains 0.5g of recombinant human collagen, and other ingredients are calculated based on this. The specific preparation method is to dissolve poloxamer, sodium hyaluronate, and glycerin into pure water, stir evenly, then add recombinant human collagen filtered through a 0.22 μm membrane, continue stirring to obtain a uniform system, and then Add antibacterial preservatives, then make up the balance with pure water, stir evenly, and finally adjust the pH value of 1 kg of the gel to 3.8 to obtain the finished product.

Embodiment 2

[0072] A recombinant human collagen vaginal gel, the ingredients include recombinant human collagen 0.1%, poloxamer 4072.5%, poloxamer 188 2.3%, sodium hyaluronate 0.23%, glycerin 2%, antibacterial and antiseptic Agent: phenoxyethanol 0.57%, sodium methylparaben 0.1%, sodium propylparaben 0.05%; the balance is water.

[0073] Taking the preparation of 1kg of gel as an example, the concentration of recombinant human collagen is 0.1%, that is, every 1kg of dressing contains 1g of recombinant human collagen, and other ingredients are calculated based on this. The specific preparation method is to dissolve poloxamer, sodium hyaluronate, and glycerin into pure water, stir evenly, then add recombinant human collagen filtered through a 0.22 μm membrane, continue stirring to obtain a uniform system, and then Add antibacterial preservatives, then make up the balance with pure water, stir evenly, and finally adjust the pH value of 1 kg of the gel to 3.9 to obtain the finished product. ...

Embodiment 3

[0075] A recombinant human collagen vaginal gel, the ingredients include recombinant human collagen 1%, poloxamer 40725%, poloxamer 188 6%, sodium hyaluronate 2%, glycerin 4%, antibacterial and antiseptic Agent: 0.1% phenoxyethanol, 3% sodium methylparaben, 2% sodium propylparaben, and the balance is water.

[0076] Taking the preparation of 1kg of gel as an example, the concentration of recombinant human collagen is 1%, that is, every 1kg of dressing contains 10g of recombinant human collagen, and other ingredients are calculated based on this. The specific preparation method is to dissolve poloxamer, sodium hyaluronate, and glycerin into pure water, stir evenly, then add recombinant human collagen filtered through a 0.22 μm membrane, continue stirring to obtain a uniform system, and then Add antibacterial preservatives, then make up the balance with pure water, stir evenly, and finally adjust the pH value of 1 kg of the gel to 3.8 to obtain the finished product.

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Abstract

The invention relates to an ordinary treatment medicine for vagina dryness, and in particular relates to recombinant human-derived collagen vagina gel for vaginal dryness. The recombinant human-derived collagen vagina gel comprises the following components in percentage by mass: 0.05-1% of recombinant human-derived collagen, 10-30% of poloxamer 407, 0.5-6% of poloxamer 188, 0.1-2% of sodium hyaluronate, 1-4% of glycerinum, an antibacterial preservative which comprises 0.1-1% of phenoxyethanol, 0.05-3% of sodium methylparaben, 0.01-2% of propylparaben, and the balance of water. By adopting the recombinant human-derived collagen vagina gel, the vagina elasticity can be improved, vaginal atrophy can be alleviated, dyspareunia can be relieved, and the sex satisfaction can be improved; by increasing secreta, improving the vagina wetness and alleviating the dryness of vaginas, pruritus, hotness and chapped skin caused by dryness can be remedied, and the symptoms of dryness and stabbing pain of vulvovagina can be alleviated. In addition, the product cannot affect the pH value of vaginas when used in the vaginas, is free of adverse reaction, and is worthy of clinical popularization and application.

Description

technical field [0001] The invention relates to a commonly used medicine for treating vaginal dryness, in particular to a recombinant human collagen vaginal gel and a preparation method thereof. Background technique [0002] Vagina is an important female reproductive organ, connecting the uterus and external genitalia, not only a channel for menstrual discharge and fetal delivery, but also a sexual organ; its structure is composed of mucous membrane, muscular layer and outer membrane, and is rich in stretchability. The maintenance of normal physiological function of female vagina is closely related to normal vaginal micro-ecological status; while ovarian function, normal vaginal structure, vaginal micro-ecological environment such as vaginal pH value (normally 3.8-4.4), microbial distribution, local cytokines and immune function are all related. It is an important factor affecting the physiological function of the vagina. [0003] When female ovarian function is normal, bec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/39A61K47/36A61K47/10A61K9/06A61P15/02A61K31/728
Inventor 胡丽娜杨霞
Owner SHANXI JINBO BIO PHARMA CO LTD
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