high performance liquid chromatography sphere

A high-performance liquid chromatography and chromatographic sphere technology, which is used in measuring devices, instruments, scientific instruments, etc., can solve problems such as easy damage and instability of the column, and achieve stable column, uniform sample distribution, and increased sample loading. Effect

Active Publication Date: 2017-01-18
CAPITAL NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a high-efficiency liquid chromatography ball, which solves the ubiquitous technical problems of column instability and easy damage in liquid chromatography columns. Advantages of large and stable column

Method used

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  • high performance liquid chromatography sphere
  • high performance liquid chromatography sphere
  • high performance liquid chromatography sphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A high performance liquid chromatography ball, figure 1 As shown, the chromatographic sphere includes a pre-column 1 , a sphere 2 and a first flange device 3 connecting the pre-column 1 and the sphere 2 .

[0032] The sphere 2 is a cavity structure formed by connecting the upper hemisphere 7 and the lower hemisphere 8 through the second flange device 9. The top of the upper hemisphere 7 is provided with an upper tube body 70 communicating with the cavity, and the nozzle of the upper tube body 70 and the pre-column 1 are fixedly connected by the first flange device 3, and the bottom end of the lower hemisphere 8 is provided with a lower pipe body 80 communicating with the cavity.

Embodiment 2

[0034] This embodiment is another implementation method of the high performance liquid chromatography sphere of the present invention. The difference from Example 1 is that, Figure 2~3 As shown, the pre-column 1 is a hollow cavity structure, and the upper half of the column body of the pre-column 1 is a stigma 4, and the lower half is a nozzle 5, and a filtering device 6 is provided in the cavity at the junction of the stigma 4 and the nozzle 5; The cavity cross section of 4 gradually increases from top to bottom, and the cavity cross section of nozzle 5 decreases gradually from top to bottom.

[0035] The pre-column of the present invention is not specifically limited on the premise of satisfying the above-mentioned structure. Preferably in this embodiment, the connection between the column head 4 and the shower head 5 forms a spherical shape with a cavity; the upper end of the column head 4 is provided with an upper pipe 40 , The lower end of the spray head 5 is provided wi...

Embodiment 3

[0039] This embodiment is another implementation method of the high performance liquid chromatography sphere of the present invention. The difference from the embodiment 1 is that the bottom of the lower hemisphere 8 is provided with a confluence mechanism, which is described in detail as follows.

[0040] Image 6 As shown, the bottom end of the lower hemisphere 8 extends upwards by 1 / 3 and a base 12 is provided. The upper nozzle of the lower tube body 8 extends upwards to the upper end of the base 12 , and the diameter gradually increases to form a bell mouth 81 . A manifold 13 is disposed above the base 12 , and a second sieve plate 14 is disposed above the manifold 13 . The upper end of the second flange device 9 is provided with a filter sheet 15 .

[0041] The chromatographic sphere of the present invention has a simple structure, and an outer cladding 10 may be provided outside the sphere 2, and the material of the outer cladding 10 is epoxy resin.

[0042] The filler...

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Abstract

The invention relates to a high-performance liquid chromatographic ball, which comprises a pre-column, a ball body and a first flange device, wherein the first flange device is connected with the pre-column and the ball body; the ball body has a cavity structure composed of an upper half ball and a lower half ball which are connected through a second flange device, an upper pipe body communicated with the cavity is arranged at the top of the upper half ball, a pipe orifice of the upper pipe body is fixedly connected with the pre-column through the first flange device, and a lower pipe body communicated with the cavity is arranged on the bottom end of the lower half ball. The technical problems that the liquid chromatographic column is commonly instable, and easily damaged can be solved, and the liquid chromatographic ball has the advantages of being simple in structure, large in injection volume, and stable in the column body.

Description

technical field [0001] The invention relates to the technical field of liquid chromatography columns, in particular to a high-performance liquid chromatography ball. Background technique [0002] Liquid chromatography is an extremely important branch of chromatographic analysis. It makes up for the limitations of gas chromatography in the analysis of high-boiling point organic substances. It can separate and analyze 80% of organic substances in nature, while gas chromatography can only It can separate and analyze 20% samples of all organic compounds, and the application of liquid chromatography makes the field of chemical analysis wider. [0003] Liquid chromatography separation technology is used to effectively separate mixture samples with multiple components, and the core component is a liquid chromatography separation column. The separation principle is that the mixed component samples are dissolved in a mobile phase, and the mobile phase flows through the chromatograph...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/60
Inventor 张玉虎王晓燕贾海峰赵远
Owner CAPITAL NORMAL UNIVERSITY
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