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Pharmaceutical composition for treating traumatic craniocerebral trauma and preparation method of pharmaceutical composition

A craniocerebral trauma and composition technology, which is applied in the field of pharmaceutical compositions for the treatment of traumatic craniocerebral trauma and its preparation, can solve the problems of lack of original basic research and achieve the effect of alleviating neuroinflammation and alleviating behavioral abnormalities

Inactive Publication Date: 2015-05-06
武汉联程生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology combines certain substances together with other compounds that are effective treatments against various types of head injuries such as gunshot wound or explosions. These combinations also have potential benefits over just one type of injury - they may even help reduce inflamed tissues around them while still maintaining their protectiveness during these attacks.

Problems solved by technology

This patented technical problem addressed in this patents is how accurately treating severely injured individuals without causing permanent damage or disability when they die shortly afterwards. Current therapies such as antiarrestants like barbiturates may temporarily reduce blood flow and potentially lead to life threatening complications. Therefore, an objective approach needs to identify specific targets involved in these injuries before developing therapeutic agents and targetable medications.

Method used

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  • Pharmaceutical composition for treating traumatic craniocerebral trauma and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating traumatic craniocerebral trauma and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating traumatic craniocerebral trauma and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A pharmaceutical preparation for treating traumatic craniocerebral trauma, prepared by the following method:

[0024] Prescription: 3,7-bis(dimethylamino)phenothiazine-5-onium chloride 40mg, [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino] Butoxy]acetic acid 13 mg.

[0025] The pharmaceutical preparation is an injection preparation, and its preparation process is: take the above-mentioned 3,7-bis(dimethylamino)phenothiazine-5-onium chloride and [4-[(5,6-diphenylpyrazinyl ) (1-methylethyl) amino] butoxy] acetic acid, add physiological saline for injection to 100ml, potting and sterilizing to obtain the injection preparation.

[0026] Usage and dosage: Intravenous injection, 10-50ml at a time, once at 0.5h after craniocerebral injury.

Embodiment 2

[0028] A pharmaceutical preparation for treating traumatic craniocerebral trauma, prepared by the following method:

[0029] Prescription: 3,7-bis(dimethylamino)phenothiazine-5-onium chloride 8mg, [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino] Butoxy]acetic acid 2.6 mg.

[0030] The pharmaceutical preparation is an injection preparation, and its preparation process is: take the above-mentioned 3,7-bis(dimethylamino)phenothiazine-5-onium chloride and [4-[(5,6-diphenylpyrazinyl ) (1-methylethyl)amino]butoxy]acetic acid, add physiological saline for injection to 1L, fill and sterilize to obtain the injection preparation.

[0031] Usage and dosage: intravenous drip, 500-1000ml once, used 0.5h after craniocerebral injury.

Embodiment 3

[0033] A pharmaceutical preparation for treating traumatic craniocerebral trauma, prepared by the following method:

[0034] Prescription: 3,7-bis(dimethylamino)phenothiazin-5-onium chloride 76.6g, [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino ]butoxy]acetic acid 25.5g.

[0035] The preparation process of the injection is: take the above-mentioned 3,7-bis(dimethylamino)phenothiazine-5-onium chloride and [4-[(5,6-diphenylpyrazinyl)(1-methyl Base ethyl) amino] butoxy] acetic acid, 150g of mannitol are mixed, add physiological saline for injection to 1000ml, adjust the pH value of the medicinal solution to 7, filter, pot, and freeze-dry to obtain the freeze-dried powder for injection.

[0036] Usage and dosage: intravenous injection or intravenous infusion, 50-300mg once, used 0.5h after craniocerebral injury.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for treating traumatic craniocerebral trauma and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from active components and conventional pharmaceutically acceptable auxiliary materials at the mass ratio of (1:1) to (5:1); and the active components are 3,7-bi(dimethylamino) phenothiazine-5-chlorlde and [4-[(5,6-diphenyl pyrazinyl)(1-methyl ethyl) amidogen] butoxy] acetic acid. The pharmaceutical composition disclosed by the invention has an obvious inhibiting effect on exitotoxicity nerve cell apoptosis caused by traumatic brain injuries, and has a neuroprotective effect; the two medicines are combined to achieve synergistic interaction; and nerve injuries and caused abnormal behaviors are further alleviated.

Description

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Claims

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Application Information

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Owner 武汉联程生物科技有限公司
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