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A biomedical multi-component copolymerization cross-linked polyester elastomer material and preparation method thereof

An elastomer material, multi-component copolymerization technology, applied in the field of biomedical multi-component copolymerization cross-linked polyester elastomer material and its preparation, to achieve the effects of good mechanical strength and high elasticity, good biocompatibility, and good biodegradability

Inactive Publication Date: 2016-05-04
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far there is no ideal bioelastomer that can meet the demand for elastomeric materials in the biomedical field

Method used

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  • A biomedical multi-component copolymerization cross-linked polyester elastomer material and preparation method thereof
  • A biomedical multi-component copolymerization cross-linked polyester elastomer material and preparation method thereof
  • A biomedical multi-component copolymerization cross-linked polyester elastomer material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A biomedical multi-component copolymerized cross-linked polyester elastomer material, the preparation method of which is:

[0036] (1) Add 1.6 mol of dehydrated L-lactic acid, 0.05 mol of dehydrated polyethylene glycol-600 and 0.15 mol of sebacic acid into a single-necked flask and mix them, and stir for 1 hour at 120°C under nitrogen protection until the sebacic acid is completely Dissolve, the system forms a clear and transparent liquid;

[0037] (2) Add 0.0017 mol of stannous octoate and 0.0017 mol of p-toluenesulfonic acid into the reaction system, keep the pressure of the reaction system at 3325 Pa, slowly increase the reaction temperature from 120°C to 180°C within 8 hours, and keep the temperature at 180°C React for 8 hours; then slowly reduce the pressure to 1.3 Pa, keep the temperature at 180°C, and react for 6 hours to obtain a linear segment with carboxyl groups at both ends formed by random copolymerization of lactic acid, polyethylene glycol-600, and sebaci...

Embodiment 2

[0042] A biomedical multi-component copolymerized cross-linked polyester elastomer material, the preparation method of which is:

[0043] (1) Add 1.2 mol of dehydrated L-lactic acid, 0.05 mol of dehydrated polyethylene glycol-600 and 0.15 mol of sebacic acid into a single-necked flask and mix them, and stir for 1 hour at 120°C under the protection of nitrogen until the concentration of sebacic acid Completely dissolved, the system forms a clear and transparent liquid;

[0044](2) Add 0.0013 mol of stannous octoate and 0.0013 mol of p-toluenesulfonic acid into the reaction system, keep the pressure of the reaction system at 3325 Pa, slowly increase the reaction temperature from 120°C to 180°C within 8 hours, and keep the temperature at 180°C React for 8 hours; then slowly reduce the pressure to 1.3 Pa, keep the temperature at 180°C, and react for 6 hours to obtain a linear segment with carboxyl groups at both ends formed by random copolymerization of lactic acid, polyethylene g...

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Abstract

The invention provides a biomedical polybasic copolymerized crosslinked polyester elastomer material which is characterized by being prepared by the following steps: mixing lactic acid, polyethylene glycol and sebacic acid and stirring at a certain temperature and under nitrogen protection till sebacic acid is fully dissolved; adding a catalyst into a reaction system to react to obtain a linear chain segment with carboxyl at two ends formed by random copolymerization of lactic acid, polyethylene glycol and sebacic acid, and adding glycerol for further reaction to obtain an uncrosslinked branched polyester prepolymer; and putting the obtained polyester prepolymer in a die and curing the prepolymer to obtain the biomedical polybasic copolymerized crosslinked polyester elastomer material with a crosslinked network structure. The crosslinked polyester material provided by the invention has good biocompatibility, biodegradability, mechanical strength and high elasticity. By adjusting the composition proportions and reaction conditions of the monomer, the performance of the material can change within a large range so as to satisfy different demands in biochemical application.

Description

technical field [0001] The invention belongs to the field of polymer material synthesis, and in particular relates to a biomedical multi-component copolymerized cross-linked polyester elastomer material and a preparation method thereof. Background technique [0002] Biomedical polymer materials are of great significance for saving lives, treating the disabled, and improving the quality of human life. Polyester is a very important class of medical polymer materials. At present, the commonly used polyester materials are generally thermoplastic materials obtained by the copolymerization of a single monomer or different monomers with similar structures. These materials have high crystallinity and high mechanical strength, which can meet the needs of many biomedical applications, such as polylactic acid. , polyglycolic acid, polylactic acid-polyglycolic acid copolymer and other polyester materials have been widely used in many biomedical fields such as surgical sutures, internal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/668C08G63/60
Inventor 何创龙贾亚听王伟忠冯炜仇可新周小军
Owner DONGHUA UNIV
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