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Dexamethasone sodium phosphate urea cream and preparation method thereof

A technology of dexamethasone sodium phosphate and urea, which is applied in the medical field, can solve problems such as repeated course of disease, patient distress, and difficult to cure, and achieve the effect of enhancing drug effect, eliminating repeated drug effect, and preventing chapped hands and feet

Inactive Publication Date: 2015-05-27
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, hormone drugs are usually used in clinical treatment, which is likely to cause repeated course of disease and is difficult to cure, which brings great troubles to patients.

Method used

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  • Dexamethasone sodium phosphate urea cream and preparation method thereof
  • Dexamethasone sodium phosphate urea cream and preparation method thereof
  • Dexamethasone sodium phosphate urea cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Dexamethasone sodium urea phosphate cream, in parts by weight, is composed of the following components: 5g dexamethasone sodium phosphate, 2000g urea, cream base; the cream base is composed of the following components:

[0019]

[0020] The preparation method of dexamethasone sodium urea phosphate cream comprises the following steps:

[0021] (1) Take the oil phase components and water phase components in the matrix and heat them to 75-80°C; the oil phase components include glyceryl monostearate, castor oil, liquid paraffin and glycerin, and the water phase components are stearic acid , triethanolamine and 10% ethylparaben tincture and purified water;

[0022] (2) After dissolving 5g of dexamethasone sodium phosphate with an appropriate amount of purified water, slowly add it to the heated water phase components in step (1);

[0023] (3) Slowly add the heated oil phase components in step (1) to the water phase components obtained in step (2), and stir in the same di...

Embodiment 2

[0028] Zhao: Female, 36 years old, with dense, red, itchy, needlepoint papules on the face, diagnosed with contact dermatitis. Use boric acid solution for cold compress, apply dexamethasone sodium phosphate urea cream externally, 3-5 times a day, and improve the next day; after 3 days, the papules decrease and the redness fades, and the symptoms disappear after 5 days. Further consultation after 1 year, no recurrence.

Embodiment 3

[0030] Li, female, 40 years old, had papular erythema on the calf, itching, and was diagnosed with eczema. Use dexamethasone sodium phosphate urea cream to smear the affected area, 3-5 times a day, and it will take effect on the same day. After 5 days of use, the symptoms will be relieved, the color of erythema will become lighter, and the area of ​​erythema will decrease. Further consultation after 8 months, no recurrence.

[0031] Example 2:

[0032] Dexamethasone sodium urea phosphate cream, in parts by weight, consists of the following components: 3g dexamethasone sodium phosphate, 2200g urea, cream base; the cream base is made up of the following components:

[0033]

[0034] The preparation method of dexamethasone sodium urea phosphate cream comprises the following steps:

[0035] (1) Take the oil phase components and water phase components in the matrix and heat them to 75-80°C; the oil phase components include glyceryl monostearate, castor oil, liquid paraffin and...

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Abstract

The invention provides a dexamethasone sodium phosphate urea cream and a preparation method thereof. The dexamethasone sodium phosphate urea cream is prepared from the following components in parts by weight: 3-8 parts of dexamethasone sodium phosphate, 1800-2200 parts of urea and emulsifiable paste matrix, wherein the dexamethasone sodium phosphate is glucocorticosteroid hormone; the pharmacological action mainly comprises anti-inflammatory, antitoxic, antiallergic and antirheumatic action; and clinical use is wide. Urea is capable of dissolving and denaturating skin keratin and increasing hydration of cuticle, so as to soften the skin and relieve the chapped skin symptom. The dexamethasone sodium phosphate urea cream provided by the invention is capable of softening the skin and preventing hands and feet from chapping; and meanwhile, a trace of dexamethasone sodium phosphate is added, compared with simply used urea or hormone drugs, the drug effect is enhanced; the side effects of the hormone drugs are reduced to the minimal extent; and meanwhile, the problem of repeated drug effect is solved.

Description

technical field [0001] The invention belongs to the medical field, and in particular relates to a medicine for external use for dermatitis and eczema, in particular to a cream containing dexamethasone sodium phosphate and urea and a preparation method thereof. Background technique [0002] Dermatitis and eczema are common inflammatory skin diseases of the epidermis and superficial dermis caused by a variety of internal and external factors. They are characterized by consciously severe itching, pleomorphic skin lesions, and symmetrical distribution. Dermatitis eczema has a tendency to exudate, and the course of the disease is chronic. , easy to relapse. At present, external application of drugs containing corticosteroids is often used for treatment. However, this treatment method is only suitable for mild or small-scale eczema / dermatitis. For large-scale eczema or recurrent eczema, if you use corticosteroid-containing drugs frequently or in large quantities for a long time, ...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K9/06A61K47/44A61P17/00A61P17/04A61P17/02A61K31/17
Inventor 王少华李志平
Owner QINGDAO MUNICIPAL HOSPITAL
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