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Aerosol precursor containing medical components of bulbus fritillaria cirrhosa and loquat syrup for treating cough and method for dispersing aerosol precursor into nanoscale fog droplets

A medicinal ingredient, loquat dew technology, which is applied in the field of aerosol precursors, can solve the problems of demanding airtightness of propellant storage tanks, poor drug atomization effect, and high cost of propellants, so as to improve the effective Utilization, overcoming losses, avoiding undruggable effects

Inactive Publication Date: 2015-05-27
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The representative patent for pressurized atomization of Chuanbei Pipa Dew is CN102949573A, in which 80-100bar propellants such as trichlorofluoromethane, dichlorodifluoromethane or dichlorotetrafluoroethane are used for atomization Micron-sized droplets can only be obtained with liquid medicine. The above-mentioned injection pressure is too high, and the airtightness of the propellant container tank is demanding, the production cost is high, and the propellant itself is also expensive.
In addition, with the increase of the amount of medicine used, the pressure inside the tank decreases continuously, and the drug atomization effect gradually becomes worse; moreover, such tanks can only be used once for consumers, increasing usage cost

Method used

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Embodiment 1

[0032] An aerosol precursor containing medicinal ingredients of Chuanbei Pipa Dew for treating cough, which includes glycerol, propylene glycol, 1,3-butanediol, flavoring substances and Chuanbei Pipa Dew extract for coughing, their quality The ratio is glycerol: propylene glycol: Cough Chuanbei Pipa Dew Extract = 40:20:1.

[0033] Wherein said Cough Chuanbei Pipa Dew Extract is obtained by a method comprising the following steps:

[0034] (1) Impurity removal: Dissolve Zhike Chuanbei Pipalou in food-grade ethanol, filter to remove insoluble impurities, and obtain Zhike Chuanbei Pipalou ethanol solution;

[0035](2) Decolorization: pass the ethanol solution of Chuanbei Pipalu obtained in step (1) through the first macroporous resin chromatographic column, and elute with ethanol-water solution with a concentration of 40% by volume to remove the pigment components therein; The model of the first macroporous resin chromatographic column is preferably MCIGEL CHP20P (75-150 μm).

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Abstract

The invention relates to an aerosol precursor containing medical components of bulbus fritillaria cirrhosa and loquat syrup for treating a cough. The aerosol precursor comprises glycerin, propylene glycol, 1,3-butanediol, a flavor component and fritillaria cirrhosa and loquat extract for treating the cough at the mass ratio of (40-45) to (20-25) to (0-10) to (0-10) to (1-10). The invention further relates to a method for dispersing the medical components in the fritillaria cirrhosa and loquat syrup for treating the cough into nanoscale fog droplets and further relates to an aerosol containing the nanoscale fog droplets. The aerosol precursor provided by the invention comprises the medical components of the fritillaria cirrhosa and loquat syrup for treating the cough. The medical components are heated in an electronic cigarette smoking set containing an electric heating apparatus to obtain the nanoscale fog droplets which facilitate absorption of a human body on the medical components.

Description

technical field [0001] The invention relates to an aerosol precursor, in particular to an aerosol precursor containing medicinal ingredients of Chuanbei Pipa Dew for treating cough and a method for dispersing it into nano-scale droplets. Background technique [0002] The main ingredients of Chuanbei Pipa Dew are loquat leaves, platycodon grandiflorum, water pinellia, flat fritillaria liquid extract, menthol, and the excipients are citric acid, benzoic acid, ethylparaben, etc. It is a brownish-red clarified Liquid; aroma, sweet taste, cool throat, and has the effect of antitussive and expectorant. Usually, Chuanbei Pipa Dew is administered orally. On the one hand, the drug effect is slow; on the one hand, it will cause irritation to the stomach; It will reduce the utilization rate of the drug. [0003] Aerosols generally refer to preparations that produce droplets when heated or pressurized. In the field of medicine and pharmacy, aerosols refer to preparations that contain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/12A61P11/14A61P11/10A24B15/16A24B15/22A61K31/045
Inventor 杨柳赵伟杨继段沅杏杨钰婷韩敬美田永峰秦云华陈永宽缪明明
Owner CHINA TOBACCO YUNNAN IND
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