Traditional Chinese medicine composition for treating senile dementia

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition for the treatment of senile dementia, can solve problems such as decreased judgment ability, difficulty in naming, and apathy

Inactive Publication Date: 2015-05-27
PEKING UNIV FOUNDER GRP CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Manifested as memory loss, prominent forgetting of recent events; decreased judgment ability, the patient cannot analyze, think, and judge events, and it is difficult to deal with complex problems; work or housework is inattentive, unable to independently carry out shopping, economic affairs, etc., social difficulties; Although still able to do some familiar daily work, he is at a loss and incomprehensible to new things, emotionally indifferent, occasionally agitated, and often suspicious; time disorientation occurs, and he can orient himself to places and people. , Difficulty in orienting to the geographical location, poor visuospatial ability of complex structures; less verbal vocabulary, difficulty in naming

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: medicine preparation

[0022] Raw materials: 10 grams of Salvia miltiorrhiza, 10 grams of angelica, 6 grams of ginseng, 6 grams of Shichangpu, 6 grams of Yizhiren, 6 grams of Chuanxiong, 10 grams of Astragalus, and 6 grams of Polygala.

[0023] Preparation steps:

[0024] 1) Weighing the bulk drug in said weight portion;

[0025] 2) Add 10 times the amount of 80% ethanol by weight, heat and reflux for extraction, repeat the above operation and extract once more, each time for 2 hours, combine the extracts, and filter to obtain the filtrate;

[0026] 3) Ethanol is recovered from the filtrate and concentrated to a thick paste;

[0027] 4) Dry the thick paste and crush it into fine powder;

[0028] 5) Divide the fine powder into capsules.

experiment example

[0029] Experimental example: drug efficacy test

[0030] Animals: 80 SPF grade KM mice, 18-22g, half male and half male.

[0031] Medicine: the traditional Chinese medicine composition of the present invention, the thick ointment fine powder of embodiment 1 is added distilled water to prepare suspension.

[0032] Control drug: piracetam tablets, made into fine powder, added with distilled water to make suspension.

[0033] experimental method:

[0034] The mice were randomly divided into 4 groups according to body weight: a control group, a model group, a Chinese medicine composition group of the present invention, and a piracetam group, with 20 mice in each group. Except for the control group intraperitoneally injected with the same amount of normal saline and gavage with the same amount of distilled water, the other groups were intraperitoneally injected with D-galactose 60mg / (kg. preparation), once a day for 60 days in a row. The Chinese medicine composition of the pres...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating senile dementia. The traditional Chinese medicine composition is prepared from following raw material mediciens, by weight: 9-15 parts of salviae miltiorrhizae, 6-12 parts of angelica sinensis, 3-10 parts of ginseng, 3-9 parts of acorus tatarinowii, 3-9 parts of fructus alpinae oxyphyllae, 3-10 parts of rhizoma chuanxiong, 10-30 parts of astragalus membranaceus and 3-9 parts of polygala tenuifolia. The eight medicines achieve the effects cooperatively and synergistically achieve the effects. The traditional Chinese medicine composition has functions of quieting spirit and boosting intelligence, resisting senile dementia and enhancing study and memory ability.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating senile dementia. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive development. Clinically, it is characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavior changes. The etiology is still unknown. Those with onset before the age of 65 are called Alzheimer's disease; those with onset after the age of 65 are called senile dementia. [0003] Clinical manifestations The onset of the disease is slow or insidious, and patients and their family members often cannot tell when the onset occurs. It is mostly seen in the elderly over 70 years old (average 73 years old for men and 75 years old for women). A small number of patients ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61P25/28
Inventor 易崇勤邹明琛郭欲晓谢小飞李育巧
Owner PEKING UNIV FOUNDER GRP CO LTD
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