Application of kainic acid in the preparation of anti-Cryptosporidium beinii medicaments

A technology of Cryptosporidium berinii and kainic acid, which is applied in the fields of application, anti-infective drugs, drug combinations, etc.

Active Publication Date: 2016-11-30
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there has been no report that kainic acid has an anti-Cryptosporidium beinii effect, and it is impossible to infer whether it has an anti-Cryptosporidium beinii effect based on the known properties of kainic acid

Method used

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  • Application of kainic acid in the preparation of anti-Cryptosporidium beinii medicaments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Preparation of kainic acid powder: take 4g of kainic acid (content not less than 99%) and 96g of starch and mix well. Kainic acid was purchased from Merck Company, Germany, article number: 420318-10MGCN.

[0013] The usage and dosage of the powder: mix the above 100g powder into 100 kg of feed, and feed according to the daily food intake.

Embodiment 2

[0015] Preparation of kainic acid water solvent: take 2 g of kainic acid (content not less than 99%) and 98 g of glucose and mix well.

[0016] Dosage of water-soluble powder: Dissolve 100g of the above-mentioned powder in 200 liters of water, cut off water for 2 hours before using the medicine, and then feed according to the normal amount of drinking water.

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Abstract

The invention discloses an application of kainic acid in preparation of anti-cryptosporidium-baileyi medicines. An application method performed by the inventors comprises the following steps: preparing powder by using kainic acid and acceptable auxiliary materials, adding the powder into a feed, uniformly mixing, and feeding Lingnan yellow chicken according to a daily feed quantity, wherein the adding amount is that 4g of kainic acid needs to be added into per 100kg of the feed; or preparing kainic acid into water-soluble powder, dissolving the powder into water, and feeding a white mouse according to the daily water-drinking amount under the condition that the adding amount equals to dissolving 2g of kainic acid into per 100kg of water. Confirmed by animal infection experiments, the oocyst excreting quantity of cryptosporidium baileyi can be reduced by more than 78% by adding kainic acid; and kainic acid has relatively good anti-cryptosporidium effects.

Description

technical field [0001] The invention relates to a new application of small molecules, in particular to the application of kainic acid in the preparation of anti-Cryptosporidium beinii medicaments. Background technique [0002] Cryptosporidiosis is one of the common parasitic diseases of poultry and wild birds. At present, there are 3 recognized effective species of Cryptosporidium parasitized in poultry: Cryptosporidium beinii ( Cryptosporidium. ), Cryptosporidium turkey ( C. meleagridis ) and Cryptosporidium gallinarum ( C. galli ). Among them, Cryptosporidium beinii is the dominant species infecting poultry. It mainly parasitizes the larynx, trachea, bursa and cloaca of poultry, causing respiratory and digestive tract lesions, resulting in decreased production performance and even death. When it is accompanied by immunosuppressive diseases or co-infection with other respiratory and gastrointestinal pathogens, it will cause more serious economic losses. [0003] In ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/401A61P33/02A23K20/142
CPCY02A50/30
Inventor 李娟孙铭飞林栩慧戚南山廖申权吴彩艳吕敏娜
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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