Application of lovastatin in preparation of drugs for resisting cryptosporidium parvum

A technology of Cryptosporidium parvum and lovastatin, applied in the direction of application, anti-infective drugs, drug combination, etc., to achieve good anti-Cryptosporidium effect

Inactive Publication Date: 2015-06-10
郑州点石生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there has been no report that lovastatin has an anti-Cryptosporidium parvum effect, and it is impossible to infer whether it has an anti-Cryptosporidium parvum effect based on the known properties of lovastatin

Method used

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  • Application of lovastatin in preparation of drugs for resisting cryptosporidium parvum
  • Application of lovastatin in preparation of drugs for resisting cryptosporidium parvum
  • Application of lovastatin in preparation of drugs for resisting cryptosporidium parvum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 lovastatin powder

[0023] Preparation of lovastatin powder: take 5g of lovastatin (content not less than 99%) and 95g of starch and mix well.

[0024] Dosage of lovastatin powder: mix the above 100g powder into 100 kg of feed, and feed according to daily food intake.

Embodiment 2

[0025] Embodiment 2 lovastatin water-soluble powder

[0026] Preparation of lovastatin water-soluble powder: Take 2.5 g of lovastatin (content not less than 99%) and 97.5 g of glucose and mix well.

[0027] Dosage of lovastatin water-soluble powder: Dissolve 100g of the above-mentioned powder in 100 liters of water, and feed according to the normal amount of drinking water.

Embodiment 3

[0028] Example 3 The Anti-Cryptosporidium Parvum Effect of Lovastatin

[0029] Experimental Materials:

[0030] Control drug: Paromomycin (98%, Shanghai Fusheng Biotechnology Co., Ltd., batch number 001010) reported in the literature with anti-Cryptosporidium parvum effect, the dosage is 5 mg / kg body weight.

[0031] Lovastatin: the lovastatin powder of embodiment 1, the lovastatin water-soluble powder of embodiment 2.

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Abstract

The invention discloses an application of lovastatin in preparation of drugs for resisting cryptosporidium parvum. Lovastatin and acceptable excipients are prepared into powder, the powder is added into a feed, the two are uniformly mixed, and then mice are fed with the mixture according to daily feed consumption; or lovastatin is prepared into lovastatin water soluble powder, the lovastatin water soluble powder is dissolved in water, and then mice are fed with the solution according to daily water consumption. Animal infection experiments prove that due to the application of lovastatin, the number of excreted oocysts of infected cryptosporidium parvum is reduced by over 86%; therefore, the lovastatin has a good effect of resisting cryptosporidium parvum.

Description

technical field [0001] The invention relates to a new application of lovastatin, in particular to the application of lovastatin in the preparation of anti-Cryptosporidium parvum drugs. Background technique [0002] Cryptosporidium (Cryptosporidium) is distributed worldwide. Cryptosporidium parvum, which infects humans and most mammals ( Cryptosporidium parvum ). Cryptosporidium is an important opportunistic pathogen causing diarrhea in humans and animals. In severe infections, the surface of the villi of the small intestine may be sunken, atrophied, shortened and thickened, or fused, displaced, and shed; this can lead to digestive and absorption disorders and diarrhea. [0003] People with normal immune function will often have self-limited diarrhea after being infected with this worm. The feces are watery and large in volume. They may have symptoms such as abdominal cramping pain, nausea, anorexia, fever and general malaise. In patients with abnormal immune function, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P33/02A23K1/16
CPCY02A50/30
Inventor 张保华
Owner 郑州点石生物技术有限公司
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