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Application of 2-ethyl methylbutyrate in preparing drug for resisting cryptosporidium parvum

A technology of ethyl methylbutyrate and Cryptosporidium parvum, which is applied in the direction of anti-infective drugs, drug combinations, and resistance to vector-borne diseases, etc., can solve problems such as the inability to infer the effect of anti-Cryptosporidium parvum, and achieve non-toxicity side effects

Active Publication Date: 2017-05-17
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there has been no report that ethyl 2-methylbutyrate has anti-Cryptosporidium parvum, and it is impossible to infer whether it has anti-Cryptosporidium parvum based on the known properties of ethyl 2-methylbutyrate

Method used

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  • Application of 2-ethyl methylbutyrate in preparing drug for resisting cryptosporidium parvum
  • Application of 2-ethyl methylbutyrate in preparing drug for resisting cryptosporidium parvum
  • Application of 2-ethyl methylbutyrate in preparing drug for resisting cryptosporidium parvum

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Effect test

Embodiment 1

[0014] The preparation of ethyl 2-methylbutyrate powder: take 5g ethyl 2-methylbutyrate (content not less than 99%) and 95g starch and mix well.

[0015] Usage and dosage of powder: add the above 100g powder to 100kg feed, and feed according to daily intake.

Embodiment 2

[0017] Preparation of ethyl 2-methylbutyrate water-soluble powder: Since ethyl 2-methylbutyrate is insoluble in water, the soluble powder is prepared using the pharmaceutical excipient 2 hydroxypropyl-β-cyclodextrin. Take 2.5g of ethyl 2-methylbutyrate (content not less than 99%), weigh 50g of 2-hydroxypropyl-β-cyclodextrin according to the molar ratio of 1:2, add 200ml of absolute ethanol, and stir for 6 hours. Evaporate to dryness under reduced pressure.

[0018] Usage and dosage of water-soluble powder: Add 52.5g of the above powder in 100 liters of water, and feed according to normal drinking water.

[0019] The following specific experiments illustrate the effect of ethyl 2-methylbutyrate against Cryptosporidium parvum.

[0020] Experimental Materials:

[0021] Control drug: Paromomycin (98%, Shanghai Fusheng Biotechnology Co., Ltd., batch number 001010) with anti-Cryptosporidium parvum effect reported in the literature, with a dosage of 5 mg / kg body weight.

[0022] Ethyl 2-meth...

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Abstract

The invention discloses application of 2-ethyl methylbutyrate in preparing a drug for resisting cryptosporidium parvum. According to the application disclosed by the invention, the 2-ethyl methylbutyrate having the function of resisting the cryptosporidium parvum is firstly discovered, and the 2-ethyl methylbutyrate, a stereoisomer of the 2-ethyl methylbutyrate, a hydrate of the 2-ethyl methylbutyrate, pharmaceutically accepted salt of the 2-ethyl methylbutyrate and the like can be utilized for preparing the drug for treating and / or preventing and / or assisting to treat proliferative diseases caused by the cryptosporidium parvum. The 2-ethyl methylbutyrate is a component of food-grade essence, is a compound in America flavor and extract manufacturers' association GRAS (Generally Recognized As Safe) certification catalog, has no toxicity and side effects on human beings and animals, and is safe and environment-friendly.

Description

Technical field [0001] The invention specifically relates to the application of ethyl 2-methylbutyrate in the preparation of medicines against Cryptosporidium parvum. Background technique [0002] Cryptosporidium (Cryptosporidium) is distributed worldwide. It is Cryptosporidium parvum (Cryptosporidium parvum) that infects humans and most mammals. Cryptosporidium is an important opportunistic pathogen that causes diarrhea in humans and animals. In severely infected people, the surface of the small intestine villi may appear sunken, atrophy, become shorter and thicker, or merge, shift, and fall off; it can cause digestion and absorption disorders and diarrhea. [0003] People with normal immune function often show self-limiting diarrhea after being infected with this worm. The stool is watery and large in volume, and may have abdominal cramping pain, nausea, anorexia, fever, and general malaise. In patients with abnormal immune function, the onset of the disease is mostly gradual,...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61P33/02
CPCA61K31/12Y02A50/30
Inventor 吕敏娜孙铭飞李娟吴彩艳廖申权戚南山林栩慧张健騑谢明权
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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