Application of ethyl 2-methylbutyrate in the preparation of anti-Cryptosporidium parvum drugs

A technology of ethyl methylbutyrate and Cryptosporidium parvum, which is applied in drug combinations, anti-infective drugs, and resistance to vector-borne diseases, etc., can solve problems such as the inability to infer the effect of anti-Cryptosporidium parvum, and achieve non-toxicity side effects

Active Publication Date: 2019-04-30
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there has been no report that ethyl 2-methylbutyrate has anti-Cryptosporidium parvum, and it is impossible to infer whether it has anti-Cryptosporidium parvum based on the known properties of ethyl 2-methylbutyrate

Method used

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  • Application of ethyl 2-methylbutyrate in the preparation of anti-Cryptosporidium parvum drugs
  • Application of ethyl 2-methylbutyrate in the preparation of anti-Cryptosporidium parvum drugs
  • Application of ethyl 2-methylbutyrate in the preparation of anti-Cryptosporidium parvum drugs

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Experimental program
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Embodiment 1

[0014] Preparation of ethyl 2-methylbutyrate powder: get 5g ethyl 2-methylbutyrate (content not less than 99%) and 95g starch and mix well.

[0015] The usage and dosage of the powder: add the above 100g powder mixed with 100kg of feed, and feed according to the daily food intake.

Embodiment 2

[0017] Preparation of ethyl 2-methylbutyrate water-soluble powder: Since ethyl 2-methylbutyrate is insoluble in water, soluble powder was prepared by using pharmaceutical excipient 2 hydroxypropyl-β-cyclodextrin. Take 2.5g of ethyl 2-methylbutyrate (content not less than 99%), weigh 50g of 2-hydroxypropyl-β-cyclodextrin according to the molar ratio of 1:2, add 200ml of absolute ethanol, stir for 6 hours, Evaporate under reduced pressure to dryness.

[0018] Dosage of water-soluble powder: dissolve the above-mentioned 52.5g powder in 100 liters of water, and feed according to the normal amount of drinking water.

[0019] The effect of ethyl 2-methylbutyrate on resisting Cryptosporidium parvum will be described below in combination with specific experiments.

[0020] Experimental Materials:

[0021] Control drug: Paromomycin (98%, Shanghai Fusheng Biotechnology Co., Ltd., batch number 001010) reported in the literature with anti-Cryptosporidium parvum effect, the dosage is 5 m...

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Abstract

The invention discloses application of 2-ethyl methylbutyrate in preparing a drug for resisting cryptosporidium parvum. According to the application disclosed by the invention, the 2-ethyl methylbutyrate having the function of resisting the cryptosporidium parvum is firstly discovered, and the 2-ethyl methylbutyrate, a stereoisomer of the 2-ethyl methylbutyrate, a hydrate of the 2-ethyl methylbutyrate, pharmaceutically accepted salt of the 2-ethyl methylbutyrate and the like can be utilized for preparing the drug for treating and / or preventing and / or assisting to treat proliferative diseases caused by the cryptosporidium parvum. The 2-ethyl methylbutyrate is a component of food-grade essence, is a compound in America flavor and extract manufacturers' association GRAS (Generally Recognized As Safe) certification catalog, has no toxicity and side effects on human beings and animals, and is safe and environment-friendly.

Description

technical field [0001] The invention specifically relates to the application of ethyl 2-methylbutyrate in the preparation of anti-Cryptosporidium parvum drugs. Background technique [0002] Cryptosporidium (Cryptosporidium) is distributed worldwide. Cryptosporidium parvum infects humans and most mammals. Cryptosporidium is an important opportunistic pathogen causing diarrhea in humans and animals. In severe infections, the surface of the villi of the small intestine may be sunken, atrophied, shortened and thickened, or fused, displaced, and shed; this can lead to digestive and absorption disorders and diarrhea. [0003] People with normal immune function will often have self-limited diarrhea after being infected with this worm. The feces are watery and large in volume. They may have symptoms such as abdominal cramping pain, nausea, anorexia, fever and general malaise. In patients with abnormal immune function, the onset of the disease is mostly gradual, but the degree of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61P33/02
CPCA61K31/12Y02A50/30
Inventor 吕敏娜孙铭飞李娟吴彩艳廖申权戚南山林栩慧张健騑谢明权
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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