Application of alantolactone in preparation of medicines for resisting cryptosporidium parvum

A technology of Cryptosporidium parvum and inulin, applied in application, anti-infective drugs, drug combination, etc.

Active Publication Date: 2015-06-03
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there is no report that inulin has anti-Cryptosporidium parvum, and it is impo...

Method used

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  • Application of alantolactone in preparation of medicines for resisting cryptosporidium parvum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Preparation of inulin powder: take 3.8g of inulin (content not less than 98%) and 96.2g of starch and mix well. Inulin was purchased from Shanghai Chunyou Biotechnology Co., Ltd., item number: P0182.

[0013] The usage and dosage of the powder: mix the above 100g powder into 100 kg of feed, and feed according to the daily food intake.

Embodiment 2

[0015] Preparation of inulin water-soluble powder: take 1.9 g of inulin (content not less than 98%) and 98.1 g of glucose and mix well.

[0016] Dosage of water-soluble powder: Dissolve 100g of the above-mentioned powder in 100 liters of water, and feed according to the normal amount of drinking water.

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Abstract

The invention discloses an application of alantolactone in preparation of medicines for resisting cryptosporidium parvum. The application method comprises the following steps: preparing powder from alantolactone and acceptable auxiliary materials; adding to a feed, mixing evenly, and feeding mouse according to the daily feed amount; or preparing an alantolactone water-soluble power from the alantolactone, dissolving into water, and feeding the mouse according to the daily water consumption. An animal infection experiment proves that the oocysts after cryptosporidium parvum injection can be reduced by 75% or above by the alantolactone; and the alantolactone has a relatively good effect of resisting cryptosporidium parvum.

Description

technical field [0001] The invention relates to a new application of a compound, in particular to the application of inulin in the preparation of anti-Cryptosporidium parvum drugs. Background technique [0002] Cryptosporidium parvum ( Cryptosporidium parvum ) is one of the zoonotic parasites that cause severe watery diarrhea in humans and animals. It is distributed worldwide, and the cryptosporidiosis caused by it has been included in the six most common diarrheal diseases in the world. It is a great life threat to infants and immunocompromised patients. [0003] The main source of infection for cryptosporidiosis is feces and vomit excreted by humans or animals containing a large number of oocysts, and the oocyst excretion cycle can last from several days to several weeks. Oocysts are brought into domestic water sources through discharge of domestic sewage and surface runoff of precipitation, making Cryptosporidium an important waterborne pathogen. Cryptosporidium parvu...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P33/02A23K1/16
CPCY02A50/30
Inventor 李娟孙铭飞林栩慧戚南山廖申权吴彩艳吕敏娜
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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