Papaya seed extract sustained-release preparation and application thereof

A technology of papaya seeds and sustained-release preparations, applied in the field of medicine, to achieve the effects of high bioavailability, reduction of glutaraldehyde organic cross-linking agent, and high biosafety

Active Publication Date: 2015-06-10
ONCOCURE BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, there is no relevant report on the preparation of a slow-release drug carrier by mixing montmorillonite, chitosan and ethyl cellulose.
The preparation process and specific application of the papaya seed extract slow-release agent of the present invention have no relevant records

Method used

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  • Papaya seed extract sustained-release preparation and application thereof
  • Papaya seed extract sustained-release preparation and application thereof
  • Papaya seed extract sustained-release preparation and application thereof

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specific Embodiment approach

[0041] In another specific embodiment, the XPO1 protein inhibitor drug is an XPO1 protein inhibitor antiviral drug, wherein the virus includes: human immunodeficiency virus (HIV), influenza virus, hepatitis B virus (HBV) , Hepatitis C Virus (HCV), Human Papillomavirus (HPV), Respiratory Syncytial Virus (RSV), Dengue Fever Virus (Dungee), Severe Acute Respiratory Syndrome Coronavirus, West Nile Virus, Herpes Simplex Virus (HSV) ), cytomegalovirus (CMV), or Merkel cell polyomavirus (MCV). Preferably, the virus includes: Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) or Human Papillomavirus (HPV).

[0042] The present invention modifies montmorillonite by adding edible acid, and mixes with chitosan and ethyl cellulose to prepare composite slow-release microspheres, which ensures that the benzyl isothiocyanate compound in the embedded papaya seed extract is Stability under acidic conditions inhibits its degradation. In addition, the papaya s...

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Abstract

The invention provides a papaya seed extract sustained-release preparation and an application thereof. The preparation is prepared through the following steps: modifying montmorillonite under an acidic condition, mixing the modified montmorillonite, ethyecellulose and chitosan to prepare modified montmorillonite-ethyecellulose-chitosan composite microspheres, and imbedding a papaya seed extract in the microspheres. According to the preparation, edible acid is added into the montmorillonite to modify the montmorillonite, and the modified montmorillonite, ethyecellulose and chitosan are mixed and prepared into the composite sustained-release microspheres, so that the stability of a benzyl isothiocyanate compound in the papaya seed extract imbedded in the microspheres under an acidic condition is guaranteed, and the degradation of the benzyl isothiocyanate compound is restrained. Besides, the papaya seed extract sustained-release preparation can release easily in intestinal juice with a slightly higher pH value, the irritating effect on stomach of benzyl isothiocyanate is reduced, and the bioavailability is greatly improved. Therefore, the papaya seed extract sustained-release preparation has huge potential market space and economic benefits.

Description

technical field [0001] The present invention relates to the field of medicine. Specifically, the present invention relates to the preparation and application of papaya seed extract sustained-release agent. Background technique [0002] Papaya (Carica Papaya L.) is a tropical evergreen fruit tree native to Mexico and Central America. In my country, it is mainly distributed in southern provinces such as Guangdong, Yunnan, Taiwan, and Fujian. In addition to being a fruit with high economic value, papaya fruit is also commonly used in the development of health care products and cosmetics. However, papaya seeds (seeds) are generally considered to have no economic value and are discarded, resulting in a waste of a valuable resource. The main chemical components contained in papaya seeds are benzyl isothiocyanate and so on. Related literature has reported the antitumor use of benzyl isothiocyanate in papaya seed extract. (Carcinogenesis.2011; 32(3):359-67; J Natl Cancer Inst. 2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/16A61K47/38A61K47/36A61P1/00A61P31/18A61P31/20A61P31/14A61P31/12
CPCY02A50/30
Inventor 杨永亮
Owner ONCOCURE BIOTECH INC
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