Novel dendritic polymer and preparation and novel application

A dendritic and polymer technology, applied in the field of novel dendritic polymers and its preparation and new applications, can solve the problems of inefficiency, damage to sperm, cumbersome operations, etc., achieve great scientific and social significance, and increase the birth rate Effect

Inactive Publication Date: 2015-06-10
韩冰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Facing the subject of rapid population expansion and many endangered species, scientists hope to regulate sex. However, the regulation of sex in vitro fertilization is currently only based on the observation of morphology under a high-power microscope, the stai...

Method used

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  • Novel dendritic polymer and preparation and novel application
  • Novel dendritic polymer and preparation and novel application
  • Novel dendritic polymer and preparation and novel application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066]2) 1 mole of 3-(2-pyridyldimercapto) propionic acid N-hydroxysuccinimide ester (compound D commercially available) and 1 mole of uric acid-L-cysteine ​​(compound C) in a weak base In the dichloromethane of neutral condition PH8, react at normal temperature for 3 hours to obtain the compound E containing the diuretic structure;

[0067] 3) 1 mole of dendrimer F is reductively decomposed into 2 moles of half dendrimer G with active groups; specifically, polyamide-amine dendrimer 1 with S-S as the core and hydroxyl as the surface The moles were reacted for 24 hours in a phosphate buffer solution (pH8) of 500 molar concentration of tris(2-chloroethyl) phosphate, and then put into a petroleum ether solvent for 1 hour. It decomposes into an active half polyamide-amine dendrimer G with a hydroxyl group as the surface.

[0068] 4) 1 mole of compound E and 1 mole of half dendrimer G were reacted for 2 hours under weakly alkaline conditions at room temperature to obtain dendritic...

Embodiment 2

[0071] 2) 2 moles of N-hydroxysuccinimide 3-(2-pyridinedimercapto) propionate (compound D commercially available) and 2 moles of uric acid-L-cysteine ​​(compound C) in a weak base In the dimethyl sulfoxide under the condition of pH8, react at room temperature for 3 hours to obtain the compound E containing the diuretic structure;

[0072] 3) 2 moles of dendrimer F are reductively decomposed into 4 moles of half dendrimer G with active groups; specifically, polyamide-amine dendrimer 2 with S-S as the core and hydroxyl as the surface The moles were reacted in a phosphate buffer solution (ph7-8) of 1000 molar concentration of tris(2-chloroethyl)phosphate for 30 hours, and put into N, N-dimethylformamide solvent for 2 hours. It decomposes into an active half polyamide-amine dendrimer G with a hydroxyl group as the surface.

[0073] 4) 1 mole of compound E and 1 mole of half dendrimer G were reacted for 2 hours under weakly alkaline conditions at room temperature to obtain dendrit...

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Abstract

The invention discloses preparation and application of a novel dendritic polymer. A dendritic compound is a dendritic high-polymer compound with a novel structure. The invention discloses a preparation method and an application of the novel dendritic polymer. The dendritic polymer with the novel structure has the effects and the capacities of non-in-vitro fertilization for people or animals, and regulation and control of birth offspring gender in a normal birth process of people or animals.

Description

technical field [0001] The invention discloses the preparation and application of a novel dendritic polymer, which refers to a dendritic polymer containing a ureuric acid structure and the preparation method and application of the polymer. Background technique [0002] At present, there is no suitable and effective method for directly screening the sex of the next generation during sexual intercourse in viviparous mammals. Facing the subject of rapid population expansion and many endangered species, scientists hope to regulate sex. However, the regulation of sex in vitro fertilization is currently only based on the observation of morphology under a high-power microscope, the staining of XY sperm, or electrophoresis, flow cytometry Other instruments or technical means to separate XY sperm not only damage the sperm during the operation, but also are cumbersome, inefficient, time-consuming and labor-intensive, and have a low success rate. The inventors have discovered a brand-...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/198A61K31/795C08G83/00A61P15/00
Inventor 韩冰王艳丽
Owner 韩冰
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