A two-stage microneedle array and its preparation method

Abstract

The invention belongs to the technical field of dosing equipment and particularly relates to a two-stage-type micro-needle array and a preparation method thereof. The two-stage-type micro-needle array comprises micro-needle lower stage bases and micro-needle upper stage tips; each micro-needle upper stage tip is of a protruding structure with a cavity, each micro-needle lower stage base is provided with a protruding structure, and each cavity of the corresponding micro-needle upper stage tip can be sleeved with the matched protruding structure; the preparation materials of the micro-needle lower stage bases are biodegradable insoluble high polymer materials; the micro-needle upper stage tips are used for loading drugs, and the preparation materials of the micro-needle upper stage tips comprise biodegradable soluble high polymer materials. Compared with the prior art, according to the two-stage-type micro-needle array, the enough hardness of the micro-needle upper stage tips is achieved due to the function of the micro-needle lower stage bases, the cuticle of the skin surface can be pierced effectively, the fast separation of a drug loading stage and a needle body is achieved, therefore, the operating time of a micro-needle is reduced, and dosing objects which are not easy to control such as animals or children are facilitated.

Description

technical field [0001] The invention belongs to the technical field of drug delivery equipment, and in particular relates to a two-stage microneedle array and a preparation method thereof. Background technique [0002] Generally speaking, there are different routes of administration, which have different curative effects. At present, most drugs are taken orally in the form of tablets or capsules to achieve curative effect, but this makes most peptide and protein drugs have been decomposed and digested when they pass through the gastrointestinal tract and liver, making them ineffective. And for injection administration, although direct and effective, it will cause pain and skin damage to the patient, and the operation is difficult, so it cannot be used by itself. [0003] Transdermal administration can avoid the above disadvantages. Skin consists of epidermis, dermis and subcutaneous tissue. The epidermis is the outermost layer of the skin, with an average thickness of 0.2...

AI Technical Summary

Problems solved by technology

However, the limitations of the above-mentioned microneedle structure make it take a long time (about 2 minutes) for the drug to enter the subcutaneous area, and the drug cannot be absorbed quickly

Images