Cobalt (ii) complexes of quinolinone derivatives and their synthesis methods and applications

A synthesis method and technology of complexes, applied in the field of medicine, can solve problems such as synthesis and application that have not yet been seen

Inactive Publication Date: 2017-05-17
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no related reports on cobalt(Ⅱ) complexes with 3-(1H-benzimidazol-2-yl)-6-methyl-2(1H)-quinolinone as ligands and their synthesis and application

Method used

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  • Cobalt (ii) complexes of quinolinone derivatives and their synthesis methods and applications
  • Cobalt (ii) complexes of quinolinone derivatives and their synthesis methods and applications
  • Cobalt (ii) complexes of quinolinone derivatives and their synthesis methods and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] In a thick-walled borosilicate glass tube open at one end, directly add 0.1 mmol CoCl 2 ·6H 2 O and 0.1 mmol BMQ, and then add 0.6 ml methanol / chloroform mixed solution (the volume ratio of methanol and chloroform is 3:1). Under the condition of vacuuming, the open end was melted and sealed, and then fully reacted at 80° C. for 72 hours to obtain a blue crystalline solid product. The product was subjected to infrared spectroscopy (e.g. Figure 4 shown), elemental analysis, electrospray mass spectrometry (such as Figure 5 shown) combined with X-ray single crystal diffraction analysis for structure (eg Figure 6 Shown) determination, identified as the target complex [Co(BMQ)Cl 2 ], its structural formula is shown in the following formula (I).

[0061]

Embodiment 2

[0063] Repeat Example 1, the difference is:

[0064] 1) The polar solvent was changed to methanol;

[0065] 2) The reaction temperature was changed to 50° C., and the reaction time was changed to 50 h.

[0066] The obtained product was determined to be the target complex [Co(BMQ)Cl 2 ].

Embodiment 3

[0068] 1) Weigh 0.1mmol CoCl respectively 2 ·6H 2 0 and 0.1mmol BMQ, after mixing, be dissolved in 80mL methanol / acetone mixed solution (the volume ratio of methanol and acetone is 1:1), obtain mixed solution;

[0069] 2) The resulting mixed solution was refluxed at 100°C for 8 hours;

[0070] 3) Part of the solvent was evaporated from the obtained reaction solution, and the product was left to stand, and a blue crystalline solid product was precipitated. The solid was separated, washed with ether, and dried.

[0071] The obtained product was determined to be the target complex [Co(BMQ)Cl 2 ].

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PUM

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Abstract

The invention discloses a cobalt (II) complex of quinolinone derivative, and a synthesis method and application thereof. The synthesis method of the quinolinone cobalt complex comprises the following steps: weighing cobaltous chloride and a ligand 3-(1H-benzimidazolyl-2-yl)-6-methyl-2(1H)-quinolinone according to the stoichiometric proportion, dissolving in a polar solvent, and carrying out complexing reaction. The research of the in-vitro antitumor activity indicates that the complex has certain proliferation inhibition activity for human cervical cancer cell Hela229, human stomach cancer cell MGC-803, human liver cancer cell strain Hep G2 and BEL-7404 cell strain, and has the maximum activity for human liver cancer cell strain Hep G2. The quinolinone cobalt complex is disclosed as the following formula (I).

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a cobalt (II) complex of quinolinone derivatives and a synthesis method and application thereof. Background technique [0002] The 2(1H)-quinolinone structure is an alkaloid that exists widely in natural products like quinoline. Compounds containing the 2(1H)-quinolinone structure have various biological activities. Different substituents can produce broad-spectrum pharmacological activities such as anti-tumor, anti-oxidation, and anti-inflammation. Seeking drug lead compounds with excellent activity and low toxicity is an important method for the development of new anti-tumor drugs. Because 2(1H)-quinolinone has the characteristics of good activity, easy structure modification and low toxicity, it is widely used Applied in the design and screening of anticancer drugs. Some compounds with 2(1H)-quinolinone skeletons have entered the clinic as anti-tumor drugs, for example: Dov...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F15/06A61K31/555A61P35/00
CPCA61K31/555C07F15/065
Inventor 彭艳马凤娥杨景枚卢幸吴亦明张国海
Owner GUANGXI NORMAL UNIV
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