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Japanese galangal flower extract for improving sugar tolerance and usage of Japanese galangal flower extract

A technology of alpinia officinalis and its extract, which is applied in the field of medicine, can solve the problems of large side effects, etc., and achieve the effects of small side effects, improvement of blood sugar level, and remarkable curative effect

Inactive Publication Date: 2015-07-08
周佩龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, existing drugs such as metformin are chemical drugs, mainly used for diabetic patients, and for patients with impaired glucose tolerance who have not yet developed diabetes, side effects are relatively large after taking these drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of embodiment 1 Alpinia officinalis extract

[0017] Weigh 1.8kg of dried alpinia officinalis, crush it into a coarse powder, put it in a sandwich pot, add purified water to cover the medicinal surface about 2cm, soak for 15 minutes, heat and boil, keep warm and decoct for 2 hours, filter after cooling, and add the filter residue After the purified water is heated and boiled, it is kept warm and decocted for 1 hour, then filtered, and the two filtrates are combined; then the filter residue is added with 78% ethanol until it is 1 cm above the medicinal surface, soaked for 3 hours, squeezed and filtered, and the filtrate is combined with the above water decoction to obtain a mixed filtrate Then heat the mixed filtrate to reflux until there is no alcohol smell, continue heating and concentrating to a thick paste, put it into a freezer for drying, crush the dry matter, and pass through a 100-mesh sieve to obtain the Alpinia officinalis extract.

Embodiment 2

[0018] The preparation of embodiment 2 Alpinia officinalis extract

[0019] Weigh 1.5kg of dried alpinia officinalis, crush it into a coarse powder, put it in a sandwich pot and mix evenly, add purified water to cover the medicinal surface about 2cm, soak for 30 minutes, heat and boil, keep warm and decoct for 1.5h, cool and filter, Add purified water to the filter residue, heat to boil, keep warm and decoct for 1 hour, then filter, and combine the two filtrates; then add 78% ethanol to the filter residue until it is 1 cm above the medicinal surface, soak for 5 hours, squeeze and filter, and combine the filtrate with the above water decoction Obtain the mixed filtrate; then heat the mixed filtrate to reflux until there is no alcohol smell, continue heating and concentrating to a thick paste, put it into a freezer for drying, crush the dried matter, pass through a 100-mesh sieve, and obtain the Alpinia japonicus extract.

Embodiment 3

[0020] Example 3 Effect test of Alpinia officinalis extract on blood sugar level in normal mice

[0021] 40 SPF grade Kunming mice, half male and half male, body weight 18-22g. All the mice were randomly divided into the following three groups, namely the blank control group, the positive control drug glibenclamide group, the low-dose and high-dose groups of Alpinia officinalis extract, 10 in each group, half male and half male. Mice in the blank control group were given equal volumes of distilled water, and glibenclamide and alpinia officinalis extracts were prepared into a certain concentration of medicinal liquid with distilled water. Phenylurea 50 mg / kg, animals in low and high doses of Alpinia officinalis extract were orally given the dry powder of Alpinia officinalis extract prepared in Example 1 at 0.2ml / l0g body weight, and the doses were 130 and 260 mg / kg respectively. Each group was intragastrically administered the corresponding test substance at 9:00 am every day,...

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Abstract

The invention discloses a Japanese galangal flower extract for improving sugar tolerance and a usage of the Japanese galangal flower extract. The extract is extracted from the raw material Japanese galangal flower, wherein the Japanese galangal flower is flower of Alpinia japonica Miq of the Alpinia genus of the ginger family. The Japanese galangal flower extract is capable of obviously improving sugar tolerance and decreasing fasting or postprandial blood glucose levels of the patients, so that the Japanese galangal flower extract plays a significant regulatory role in the blood glucose level of the patient with abnormal glucose tolerance, hyperglycemia or diabetes; thus, the Japanese galangal flower extract can be developed into drugs, health foods or functional foods for the patients with abnormal glucose tolerances. The Japanese galangal flower extract has relatively wide applicable crowd.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an extract of Alpinia officinalis for improving glucose tolerance and its application. Background technique [0002] Impaired glucose tolerance is the compensatory stage of human glucose metabolism disorder, or the transition stage from early diabetes to diabetes. Impaired glucose tolerance does not mean that you have diabetes, but it means that the islet function of the patient has been abnormal, and you are more likely to develop diabetes than normal people. At the same time, there is an increased risk of cardiovascular disease and microvascular disease. Such patients should cause high alert. When the glucose tolerance of the human body is slightly reduced, most people may not feel any obvious discomfort, so many people do not pay attention to it and do not take any treatment measures. Experts pointed out that although people with impaired glucose tolerance can...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A23L1/29A61P3/10A23L33/00
Inventor 周佩龙
Owner 周佩龙
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