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Application of evening primrose stems and leaves in preparing nitrite scavenging agent

A nitrite and scavenger technology, which is applied in medical preparations containing active ingredients, anti-toxins, food science, etc., can solve the problem of blank nitrite scavenging activity of evening primrose stems and leaves

Inactive Publication Date: 2015-07-15
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few literature reports on the chemical composition, biological activity and product development of evening primrose stems and leaves, and the research on the nitrite scavenging activity of evening primrose stems and leaves is even blank

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the application of evening primrose stems and leaves to remove nitrite

[0019] 1. Preparation of Evening Primrose Stem and Leaf Nitrite Scavenger

[0020] Fresh evening primrose stems and leaves were collected, dried in the shade, ultrasonically extracted three times with 75% ethanol for 30 minutes each time, filtered, combined with the filtrates, evaporated to dryness, and pulverized to prepare a hard capsule preparation.

[0021] 2. Study on the scavenging activity of evening primrose stems and leaves

[0022] 2.1 Materials and methods

[0023] 2.1.1 Experimental materials

[0024] Raw material: Evening primrose stem and leaf nitrite scavenger.

[0025] Reagents: Vc, p-aminobenzenesulfonic acid, naphthylethylenediamine hydrochloride, sodium nitrite, disodium hydrogen phosphate, citric acid, ethanol and other reagents are of analytical grade.

[0026] Instruments: electronic balance, vortex mixer, CNC ultrasonic cleaner, automatic microplate reader. ...

Embodiment 2

[0045] Embodiment 2: the preparation of evening primrose stem and leaf soft capsule

[0046] Fresh evening primrose stems and leaves were collected, dried in the shade, extracted with ethanol ultrasonically for three times for 30 minutes each time, filtered, combined with the filtrate, evaporated to dryness, and reconstituted with soybean oil as a dissolving ultrasonic suspension to prepare soft capsules.

Embodiment 3

[0047] Example 3: Preparation of Evening Primrose Stem and Leaf Tea Bag

[0048] Collect fresh evening primrose stems and leaves, dry in the shade, pulverize, pass through a 40-mesh sieve, 24-mesh sieve, sterilize with an ultraviolet lamp, mechanically bag, package, print the date, plastic seal, and put into storage.

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PUM

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Abstract

The invention relates to the field of traditional Chinese medicines, and in particular relates to an application of evening primrose stems and leaves in preparing a nitrite scavenging agent. The nitrite scavenging agent of the evening primrose stems and leaves has a relatively strong scavenging capacity on nitrite, and the scavenging agent can be further developed as food, health food or a medicine for reducing cancer incidence and for controlling nitrite poisoning in people smoking for a long term (the secretion of a cancerogenic substance, namely tobacco specific N-nitrite, into bile duct can be promoted by smoking) or having high intake of other nitrites; and the scavenging capacity on the nitrite is equal to that of vitamin C.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a nitrite scavenger. Background technique [0002] Nitrosamines (NAS) are strong carcinogens for humans and animals, and can generally enter the body through food and drinks. In recent years, cancer diseases such as gastric cancer, esophageal cancer, nasopharyngeal cancer and bladder cancer have frequently occurred, which are directly related to the content of N-nitroso compounds in the body. Among them, N-dimethylnitrosamine (NDMA) is the most common carcinogenic NAS in food. Dimethylamine (DMA) and nitrite are direct precursors of carcinogenic NDMA. And dimethylamine, diethylamine, trimethylamine and trimethylamine oxides are mostly found in fish and marine organisms such as squid, octopus and so on. In food, nitrite is present in almost all pickled products, meat products, pickles and vegetables after harvesting. Nitrite is also often used as a food preservativ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P39/02A23L2/38A23L2/39A61K127/00A61K135/00
Inventor 赵岩蔡恩博郜玉钢刘学周张连学何忠梅王立岩刘双利杨鹤雷锋杰
Owner JILIN AGRICULTURAL UNIV
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