Acyclovir tablet composition

A technology of Wei tablet and composition, which is applied in the field of acyclovir tablet composition, can solve the problems of prolonged disintegration time limit and improper water content of raw materials and auxiliary materials, and achieves the effect of precise formula and reduced disintegration time limit.

Inactive Publication Date: 2015-07-22
NANJING REAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, improper selection of binders, improper water content of raw and auxiliary materials, and excessive use of lubricants will cause the extension of the disintegration time limit

Method used

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  • Acyclovir tablet composition
  • Acyclovir tablet composition
  • Acyclovir tablet composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）

[0017] (Example 1) Take the main and auxiliary materials according to the following proportions:

[0018]

[0019] According to the procedures of granulation, drying, mixing and tabletting, equipment such as a three-dimensional mixer and a tablet press is used to prepare the above-mentioned components into acyclovir tablets. The disintegration time measured by the tablet disintegration time tester was 11.5 minutes. (Example 2) Take the main and auxiliary materials according to the following proportions:

[0020]

[0021]

[0022] According to the procedures of granulation, drying, mixing and tabletting, equipment such as a three-dimensional mixer and a tablet press is used to prepare the above-mentioned components into acyclovir tablets. The disintegration time measured by the tablet disintegration time tester was 11.2 minutes. (Example 3) Take each main and auxiliary material according to the following proportioning ratio:

[0023]

[0024] According to the pro...

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PUM

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Abstract

The present invention relates to an acyclovir tablet composition, which comprises acyclovir, a binder, a disintegrant, a lubricant and a filler, wherein the binder is selected from ethanol, a starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose and a polyvinylpyrrolidone ethanol solution, the disintegrant is selected from dry starch, sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone, and cross-linked sodium carboxymethyl cellulose, the lubricant is selected from magnesium stearate, silica gel micro-powder, and talc powder, and the filler is selected from lactose, compressible dry starch, and microcrystalline cellulose. According to the present invention, the suitable prescription is preferably selected, the formula is accurate, the reasonable auxiliary material ratio is designed, and the disintegration time limit of the acyclovir is effectively reduced; and the disintegration time limit of the acyclovir is less than 12 min.

Description

technical field [0001] The invention relates to a medical preparation containing organic active ingredients, in particular to an acyclovir tablet composition. Background technique [0002] Aciclovir is a synthetic purine nucleoside analogue. It is mainly used for various infections caused by herpes simplex virus, and can be used for initial or recurrent skin, mucous membrane, external genital infection and HSV infection in immunocompromised persons. It is the drug of choice for the treatment of HSV encephalitis, and it is superior to adenosine vidarabine in reducing morbidity and mortality. It can also be used for herpes zoster, Epstein-Barr virus, and immunodeficiency complicated by chickenpox and other infections. For topical use on the skin only, acyclovir has less skin absorption. Aciclovir was successfully developed by Glaxo Wellcome in 1981 and belongs to nucleoside antiviral drugs. The drug is listed in the UK for the first time, and it is effective for various he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/522A61K47/38A61K47/36A61K47/32A61K47/26A61P31/22
Inventor 相文杰时文祥于居超
Owner NANJING REAL PHARMA
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