Preparation method of fresh ginseng freeze-dried oral instant preparation

A technology of oral instant and oral instant tablets, which is applied in freeze-dried transportation, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of undiscovered fresh ginseng extract, and achieve strong ginseng taste, more retention, and biological Highly usable effect

Active Publication Date: 2017-12-15
北京同仁堂健康药业(辽宁)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Freeze-dried preparations and literature reports of fresh ginseng extract have not been found so far

Method used

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  • Preparation method of fresh ginseng freeze-dried oral instant preparation
  • Preparation method of fresh ginseng freeze-dried oral instant preparation
  • Preparation method of fresh ginseng freeze-dried oral instant preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] After washing, take 10kg of fresh ginseng and 25kg of pure water and use a colloid mill to grind at 20°C for 10 minutes, keep warm at 67°C and grind for 5 minutes, filter, squeeze the residue, combine the filtrate, put it into an ultra-high pressure equipment kettle, and increase the pressure to 550Mpa, keep it for 10 minutes to get ginseng extract, fill the ginseng extract into aluminum-plastic blisters, spray into liquid nitrogen for quick freezing, put it in a freeze dryer, quick freeze to -52°C, keep it for 2 hours, and vacuum to 1.5Pa, then raise the temperature of the plate layer to -40°C, maintain for 3 hours, raise the temperature to -30°C, maintain for 3 hours, until the sublimation drying is completed; then raise the temperature of the plate layer to 30°C, until the analysis and drying Film packaging, prepared into fresh ginseng freeze-dried oral instant tablets.

[0029] The total saponin content of ginseng was determined to be 3.6%, and the disintegration ti...

Embodiment 2

[0031] After washing, take 10kg of fresh American ginseng and 10kg of pure water and use a colloid mill to grind at 25°C for 20 minutes, keep warm at 70°C for 4 minutes, filter, squeeze the residue, combine the filtrate, put it into an ultra-high pressure equipment kettle, and raise the pressure to 500Mpa, keep it for 15 minutes to get the American ginseng extract, fill the American ginseng extract into a freeze-dried bottle, put it into a freeze dryer, freeze it to -55°C, keep it for 2 hours, vacuumize it to 2Pa, and then lower the temperature of the plate layer Raise the temperature to -40°C and maintain it for 3 hours, raise the temperature to -30°C and maintain it for 4 hours until the sublimation drying is completed; then raise the temperature of the plate layer to 30°C until the analysis and drying is completed, and prepare fresh ginseng freeze-dried oral instant powder .

[0032] The total saponin content of ginseng was determined to be 6.8%, and the disintegration time...

Embodiment 3

[0034]Wash and cut 10kg of fresh American ginseng, 30kg of pure water, 500g of fresh dendrobium cut into small flakes, use a colloid mill to grind at 20°C for 12 minutes, keep warm at 65°C for 6 minutes, filter, and squeeze the residue. Combine the filtrates, put them into an ultra-high pressure equipment kettle, increase the pressure to 600Mpa, and maintain for 12 minutes to obtain the American ginseng extract, fill the American ginseng extract into a freeze-drying bottle, put it in a freeze dryer, and freeze it to -50°C. Keep it for 2 hours, evacuate to 1Pa, then raise the temperature of the plate layer to -40°C, maintain it for 4 hours, raise the temperature to -30°C, maintain it for 3 hours, until the sublimation drying is completed; then raise the temperature of the plate layer to 30°C, Until the analysis and drying are completed, it is prepared into a freeze-dried oral instant powder of Dendrobium ginseng.

[0035] The total saponin content of ginseng was determined to b...

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Abstract

The invention discloses a preparation method of a freeze-dried oral instant preparation of fresh ginseng, which belongs to the technical field of medicine and health products. The preparation method of fresh ginseng freeze-dried oral instant preparation, take fresh ginseng into pure water, use a grinder to grind, filter, squeeze the residue, combine the filtrate, put it into an ultra-high pressure equipment kettle, boost the pressure to 500‑600Mpa, and maintain 10‑ In 15 minutes, the ginseng extract was obtained, filled into freeze-dried bottles, put into a freeze-drying machine, quick-frozen, vacuumized, and then the temperature of the plate layer was raised until the analysis and drying were completed, and the fresh ginseng freeze-dried oral instant preparation was made. The ginseng freeze-dried oral instant preparation prepared by this method has the characteristics of fast disintegration speed, high bioavailability, high dissolution rate, small loss of nutritional components, easy absorption by human body, fast absorption speed and less loss of volatile oil components.

Description

technical field [0001] The invention relates to a preparation method of fresh ginseng freeze-dried oral instant preparation, which belongs to the technical field of medicine and health products. Background technique [0002] Ginseng is an important traditional medicinal herb, generally including Panax ginseng (Latin name Panax ginseng C. A. Mey.) and American ginseng ( Panax quinquefolium L.) and Panax notoginseng ( Panax notoginseng (Burk.) F.H.Chen), ginseng medicinal materials contain a variety of physiologically active ingredients, including dozens of ginsenosides, polysaccharides, polypeptides and volatile components. Current research shows that ginseng has the functions of nourishing vitality, restoring pulse and solidifying, and nourishing the spleen. Tonify the lungs, promote body fluid and soothe the nerves. [0003] The currently known solid dosage forms of ginseng medicinal materials mainly include ordinary tablets, capsules, and pill dosage forms. General...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61K9/19A23L33/00A61P1/14A61P9/00A61P1/00A61P11/00A61P25/20
Inventor 董英杰艾莉王会芳邹晓峰韩亚男李晓怡
Owner 北京同仁堂健康药业(辽宁)有限公司
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