External traditional Chinese medicine composition with effects of relieving allergy and resisting irritation and preparation method of composition

An anti-irritant and composition technology, applied in the field of external use of traditional Chinese medicine compositions, achieves the effects of improving skin immunity and resistance, easy access, and inhibiting cell DNA damage and leakage

Active Publication Date: 2015-07-22
SHANGHAI ZHONGYI DAILY CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are also sensitizing risk substances in cosmetics

Method used

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  • External traditional Chinese medicine composition with effects of relieving allergy and resisting irritation and preparation method of composition
  • External traditional Chinese medicine composition with effects of relieving allergy and resisting irritation and preparation method of composition
  • External traditional Chinese medicine composition with effects of relieving allergy and resisting irritation and preparation method of composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The preparation of embodiment 1 this Chinese medicine composition

[0054] (1) After the following raw materials are pulverized, weigh and mix them according to the weight ratio;

[0055] Lingxiaohua 20g, melon root 10g, sand ginseng 5g, cactus 10g, sophora flavescens 1g, radix radix 1g, sweet tea 5g.

[0056] (2) Extract with 65% ethanol by volume, the g / mL mass-volume ratio of crude drug to ethanol is 1:15, and extract for 3 hours at 70°C;

[0057] (3) cooling the extract obtained in step (2) to room temperature 20° C., and filtering through 100 mesh to obtain the filtrate;

[0058] (4) The 1,3-butanediol of the original ethanol amount is added to the filtrate, and the 1,3-butanediol is miscible evenly, and the ethanol in the solution is evaporated by rotary evaporation, and a 1.2 μm filter plate is spread in a Buchner funnel, and the above-mentioned obtained filtrate is vacuum filtered and collected. The filtrate is ready.

Embodiment 2

[0059] Embodiment 2 The preparation of this Chinese medicine composition

[0060] (1) After the following raw materials are pulverized, weigh and mix them according to the weight ratio;

[0061] Lingxiaohua 10g, melon root 5g, sand ginseng 1g, cactus 1g, sophora flavescens 10g, Ophiopogon japonicus 5g, sweet tea 10g.

[0062] (2) Extract with ethanol with a volume percentage of 95%, the mass volume ratio of the crude drug to ethanol (g / mL) is 1:30, and extract at 90°C for 1 hour;

[0063](3) cooling the extract obtained in step (2) to room temperature of 30° C., and filtering through 200 mesh to obtain the filtrate;

[0064] (4) The 1,3-butanediol of the original ethanol amount is added to the filtrate, and the 1,3-butanediol is miscible evenly, and the ethanol in the solution is evaporated by rotary evaporation, and a 1.2 μm filter plate is spread in a Buchner funnel, and the above-mentioned obtained filtrate is vacuum filtered and collected. The filtrate is ready.

Embodiment 3

[0065] Embodiment 3 The preparation of this Chinese medicine composition

[0066] (1) After the following raw materials are pulverized, weigh and mix them according to the weight ratio;

[0067] Lingxiaohua 1g, melon root 1g, sand ginseng 10g, cactus 15g, sophora flavescens 5g, radix radix 10g, sweet tea 1g.

[0068] (2) Extract with ethanol with a volume percentage of 50%, the mass volume ratio of the crude drug to ethanol (g / mL) is 1:10, and extract at 80°C for 4 hours;

[0069] (3) cooling the extract obtained in step (2) to room temperature (25° C.), and filtering through 200 mesh to obtain the filtrate;

[0070] (4) The 1,3-butanediol of the original ethanol amount is added to the filtrate, and the 1,3-butanediol is miscible evenly, and the ethanol in the solution is evaporated by rotary evaporation, and a 1.2 μm filter plate is spread in a Buchner funnel, and the above-mentioned obtained filtrate is vacuum filtered and collected. The filtrate is ready.

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Abstract

The invention discloses external traditional Chinese medicine composition with effects of relieving allergy and resisting irritation. The external traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-20 parts of campsis grandiflora, 1-10 parts of muskmelon root, 1-10 parts of root of straight ladybell, 1-15 parts of cactuses, 1-10 parts of radix sophorae flavescentis, 1-10 parts of radix ophiopogonis and 1-10 parts of hydrangea aspera don. Experiments prove that the composition has an antagonistic effect on irritation of surfactants and preservatives in cosmetics, has effective effects of inhibiting allergy and relieving itching, and has effects of inhibiting type I hypersensitivity (immediate hypersensitivity) by reducing the content of IL-6 (interleukin-6) and inhibiting type IV hypersensitivity (delayed hypersensitivity) by reducing the content of IL-8. The composition further has effects of whitening and moisturizing skin and achieves the effect of a skin barrier. The raw materials are easily available, a preparation method is simple, convenient, environment-friendly and safe, and the composition is easily accepted by people suffering from allergies, thereby having very good application and market prospects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for external use, in particular to a traditional Chinese medicine composition for external skin care with soothing and anti-irritant effects and a preparation method thereof. Background technique [0002] According to the domestic epidemiological survey, the incidence of allergic diseases in my country was as high as 37.3% in 2010, of which the skin sensitive population was about 3%, and it increased at a rate of 23 times every 10 years. Most consumers use skin care products to resist skin damage and stay away from allergies. However, there are also sensitizing risk substances in cosmetics. my country's national standard GB 17149.2-1997 "Diagnostic Criteria and Treatment Principles for Cosmetic Contact Dermatitis" issued in 1997 lists more than 130 common allergens of cosmetic contact dermatitis. Consumers are more concerned about the irritation and sensitivity caused by cosmetics th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P17/00A61P37/08A61K8/97A61Q19/00A61Q19/02
Inventor 赵仕芝董义伟陈虎
Owner SHANGHAI ZHONGYI DAILY CHEM CO LTD
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