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Application of METRNL protein as colon cancer diagnostic marker and kit

A kit, technology for colon cancer, applied in the field of biology

Active Publication Date: 2015-07-29
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Yet, about Metrn1 albumen as the application of colon cancer diagnosis serum marker and kit thereof, also do not see the report at present

Method used

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  • Application of METRNL protein as colon cancer diagnostic marker and kit

Examples

Experimental program
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Effect test

Embodiment

[0021] Example Immunohistochemical analysis of METRNL protein in colon cancer tissue chip

[0022] In order to confirm the expression difference of METRNL protein between colon cancer tissues and adjacent tissues, 30 pairs of colon cancer tissues and corresponding adjacent tissues were randomly selected, and the colon cancer tissue chip (OD-CT-DgCol03-003, purchased The immunohistochemical research was carried out from Shanghai Xinchao Biotechnology Co., Ltd., and the specific information of the selected samples is shown in Table 1.

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Abstract

The invention provides application of METRNL protein as a protein molecule marker for detecting colon cancer and application of the METRNL protein in preparing a colon cancer diagnostic reagent or a kit. Immunohistochemistry is carried out on 30 pairs of human colon cancer tissues and para-carcinoma tissues through immunohistochemistry tests, and the result proves that the METRNL protein has differential expression in cancer tissues and para-carcinoma tissues of the human colon cancer. Therefore, whether a patient has the colon cancer can be detected according to the expression quantity of the METRNL protein in colon tissues.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to METRNL protein as a colon cancer diagnostic marker and its use in preparing colon cancer diagnostic reagents or kits. Background technique [0002] Colon cancer is one of the most common malignant tumors in the world, and it is the main cause of death in many countries. The onset of colon cancer is insidious, and there are often no obvious clinical symptoms in the early stage, and the disease develops slowly. Most patients have already reached the middle and late stages when obvious symptoms appear. At present, the treatment of the colon is mainly based on surgery, but the effect of chemotherapy after colon cancer metastasis is poor, and about 40% of patients relapse after surgery, and the postoperative survival rate of advanced patients is low. Therefore, finding and discovering valuable tumor markers has important clinical guiding significance for improving the diagnos...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/57419G01N33/57484G01N33/6893
Inventor 缪朝玉范茂兵李志勇
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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