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Aerosol precursor containing medicinal composition of oral medication for treating common cold and method for dispersing aerosol precursor into nano-scale droplets

A technology for medicinal components and aerosols, which is applied in the field of aerosol precursors and can solve the problems of high cost of propellants, high injection pressure, and reduced pressure in the tank.

Inactive Publication Date: 2015-08-12
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The representative patent for pressurized atomization of traditional Chinese medicine compound preparations is CN102949573A, in which an 80-100bar propellant such as trichlorofluoromethane, dichlorodifluoromethane or dichlorotetrafluoroethane is used to atomize the liquid medicine to To obtain micron-sized mist droplets, the above-mentioned injection pressure is too high, the airtightness of the propellant container tank is strict, the production cost is high, and the propellant itself is also expensive
In addition, with the increase of the amount of medicine used, the pressure inside the tank decreases continuously, and the drug atomization effect gradually becomes worse; moreover, such tanks can only be used once for consumers, increasing usage cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] An aerosol precursor comprising an orally administered medicinal ingredient for treating colds, which includes glycerin, propylene glycol, 1,3-butanediol, flavoring substances and syrup extracts for treating colds, and their mass ratio is Triol: Propylene Glycol: Cold Syrup Extract = 40:20:1.

[0050] Wherein the syrup extract for treating cold is obtained by the method comprising the following steps:

[0051] (1) Impurity removal: dissolving cold and cough syrup in food-grade ethanol, filtering, removing insoluble impurities, and obtaining the ethanol solution of the syrup for treating colds;

[0052] (2) decolouring: the ethanol solution of the syrup for treating cold obtained in step (1) is passed through the first macroporous resin chromatographic column, and is 50 volume % ethanol-water solution elution with concentration, removes the pigment component wherein; Wherein The model of the first macroporous resin chromatographic column is preferably MCIGEL CHP20P (75-...

Embodiment 2

[0057] An aerosol precursor comprising an orally administered drug active ingredient for treating colds, which includes glycerin, propylene glycol, 1,3-butanediol, flavoring substances and tablet extracts for treating colds, and their mass ratio is Glycerol: propylene glycol: tablet extract for cold treatment = 40:20:1.

[0058] Wherein the oral drug extract for treating cold is obtained by the method comprising the following steps:

[0059] (1) Impurity removal: the mulberry ginger cold tablet is ground into powder and dissolved in food-grade ethanol, filtered to remove insoluble impurities to obtain the ethanol solution of the tablet for treating cold;

[0060] (2) Decolorization: the ethanol solution of the tablet for treating cold obtained in step (1) is passed through the first macroporous resin chromatographic column, and is eluted with ethanol-water solution with a concentration of 50% by volume to remove the pigment component therein; The model of the first macroporou...

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Abstract

The present invention relates to an aerosol precursor containing the medicinal composition of an oral medication for treating the common cold, which comprises glycerin, propylene glycol, 1,3-butylene glycol, a flavor component and an oral medication extract for treating the common cold in the mass percentage of (40-45):(20-25):(0-10):(0-10):(0-10) correspondingly. According to the technical scheme, the invention also relates to a method for dispersing the medicinal composition of the oral medication for treating common cold into nano-scale droplets, and an aerosol containing the nano-scale droplets. The aerosol precursor contains the medicinal composition of the oral medication for treating common cold. The aerosol precursor is placed in an electronic cigarette smoking set comprising an electric heater so as to be heated to generate nano-scale droplets. Therefore, the absorption effect of the medicinal composition by human bodies is better.

Description

technical field [0001] The invention relates to an aerosol precursor, in particular to an aerosol precursor containing an orally administered medicinal ingredient for treating colds and a method for dispersing it into nano-scale droplets. Background technique [0002] Cold medicine generally refers to various medicines used to treat colds, including Chinese patent medicines, decoctions, western medicines, granules and so on. The treatment of colds aims to decongest the nasal mucosa, relieve the swelling of capillaries in the nasal cavity, relieve nasal congestion, and reduce nasal secretions; it also helps to keep the eustachian tube and sinus ostia open, thereby preventing secondary infection. Due to the rapid onset of colds and the complex and diverse symptoms, there is no medicine so far that can solve all these problems. Therefore, compound preparations are often used for the treatment of colds. At present, Chinese medicine compound preparations for treating colds inclu...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K36/8998A61K36/9068A61K36/899A61K36/815A61K36/704A61K36/855A61K36/634A61K9/12A24B15/00A61P11/00A61P11/14A61K31/045A61K35/32A61K33/06
Inventor 杨柳赵伟尚善斋田永峰韩敬美雷萍张霞段沅杏杨继朱东来巩效伟李寿波韩熠孙志勇陈永宽缪明明
Owner CHINA TOBACCO YUNNAN IND
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