Taste correction method for oral liquid preparation of traditional Chinese medicine containing ethyl alcohol

A technology of oral preparations and traditional Chinese medicines, which is applied in the field of flavor correction of ethanol-containing Chinese medicine liquid oral preparations. It can solve problems such as the influence of key attributes such as product clarity, reduced medication compliance, and complicated flavor correction methods, and achieves suppression of bitterness and irritation. Odor, taste improvement, easy operation effect

Inactive Publication Date: 2015-08-19
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For commonly used dosage forms such as tablets, pills, granules, oral liquids, etc., the flavor correction method is relatively simple, and the impact on the sample is small after adding the flavoring agent; however, the flavor correction method of the ethanol-containing traditional Chinese medicine liquid oral preparation is more complicated and difficult The main reason is that high concentration of ethanol brings strong irritation, and combined with the sour and bitter taste of traditional Chinese medicine ingredients and the special irritating smell of traditional Chinese medicine, the patient's compliance with ethanol-containing traditional Chinese medicine preparations is greatly reduced. The addition of flavoring agents can easily affect key attributes such as product clarity
Literature search shows that there is no relevant literature or patent report on this method at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 Gutongling tincture

[0018] The composition of the original prescription: 80g Artemisia arvensis, 110g dried ginger, 1g dragon's blood, 5g frankincense, 5g myrrh, and 1.5g borneol.

[0019] Each medicinal material is prepared 1000ml tincture according to the process method of the 2010 edition Chinese Pharmacopoeia. During the production process, take 15g of sucralose, add it to the percolation liquid after mixing, let it stand for 48 hours, filter, and adjust the filtrate to 1000ml with water and ethanol to obtain the product.

[0020] The step of adding the sweetener in this embodiment is standing still, which can ensure the clarity of the final product. Gutongling tincture prepared by this method is sweet in mouth, strong in irritation, slightly bitter in mouth, strong in irritation residue, and the dosage for patients remains unchanged.

[0021] In this embodiment, a sweetener is used alone, which cannot effectively cover the irritation at the entranc...

Embodiment 2

[0022] Embodiment 2 Gutongling tincture

[0023] The composition of the original prescription: 80g Artemisia arvensis, 110g dried ginger, 1g dragon's blood, 5g frankincense, 5g myrrh, and 1.5g borneol.

[0024] Each medicinal material is prepared 1000ml tincture according to the process method of the 2010 edition Chinese Pharmacopoeia. During the production process, take 7.5g of sucralose, 12.5g of sodium saccharin, and 5g of vanillin, add them to the percolation liquid after mixing, let it stand for 48 hours, filter, and adjust the filtrate to 1000ml with water and ethanol, that is have to.

[0025] In this embodiment, the addition of sweetener and flavoring agent is to stand still, which can ensure the clarity of the final product. The Gutongling tincture prepared by this method is sweet in mouth, weak in irritation, fragrant in taste, slightly bitter in mouth, weak in bitterness and irritation, and the dosage for patients remains unchanged.

[0026] The excipients used f...

Embodiment 3 10

[0028] Embodiment 3 ten drops of water

[0029] The original prescription consists of 25g camphor, 25g dried ginger, 20g rhubarb, 10g cumin, 10g cinnamon, 5g pepper, and 12.5ml eucalyptus oil.

[0030] Each medicinal material is prepared 1000ml tincture according to the process method of the 2010 edition Chinese Pharmacopoeia. During the preparation process, take 1 g of sucralose, 15 g of acesulfame potassium, 4 g of geranial, 120 ml of glycerin and 10 ml of lemon-flavored essence, add them to the collected percolate, stir to dissolve, and obtain the product.

[0031] In this embodiment, the addition of sweetener and flavoring agent is mixing, which can ensure the clarity of the final product. The ten drops of water prepared by this method is sweet in the mouth, weak in irritation, fragrant in taste, slightly bitter in the mouth, weak in bitterness and irritation, and the dosage for patients remains unchanged.

[0032] The excipients used for flavor correction in this exampl...

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PUM

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Abstract

The invention disclose a taste correction method for oral liquid preparation of traditional Chinese medicine containing ethyl alcohol, and the taste correction method comprises the following steps of adding an auxiliary material used for correcting taste into the oral liquid preparation of traditional Chinese medicine containing ethyl alcohol, dissolving and mixing evenly. The taste correction method provided by the invention can eventually achieve the purpose that the needs of different groups can be met and the bad taste of the oral liquid preparation of traditional Chinese medicine containing ethyl alcohol can be corrected. The taste correction method has the advantages that the operation is simple, the application is wide, the product taste is significantly improved, and the method is suitable for industrialized production, can ensure the different needs of different groups on medicine taste, meet the needs of special populations on taste correction agent, and the products are suitable for old people, children, and diabetes.

Description

technical field [0001] The invention relates to a method for correcting the taste of oral preparations of traditional Chinese medicines, in particular to a method for correcting the tastes of liquid oral preparations of traditional Chinese medicines containing ethanol. Background technique [0002] Poor mouthfeel is one of the inherent defects of oral preparations of traditional Chinese medicine, and it is also the biggest obstacle affecting patients' medication compliance. The commonly used methods in the study of traditional Chinese medicine flavoring are dosage form changes, part of the preparation process changes, and the addition of flavoring agents, among which adding flavoring agents is the method of flavoring with the simplest technology, the most economical cost, and the most obvious effect. Now there are many varieties of traditional Chinese medicines on the market and under research that have adopted the method of adding flavoring agents to improve the taste. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/26A61K47/22A61K47/18A61K9/08A61K36/9068A61K36/889A61K36/74A61K36/481A61K31/045
Inventor 吴飞冯怡洪燕龙王优杰林晓胡佳亮
Owner SHANGHAI UNIV OF T C M
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