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Curcumin cyclodextrin clathrate compound and preparation method thereof

A technology of cyclodextrin inclusion compound and cyclodextrin, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations of non-active ingredients, etc., can solve the problems of organic solvent residue and high proportion of degradation products, and achieve improved stability and Bioavailability, enhanced water solubility and biocompatibility, and effects of avoiding degradation

Inactive Publication Date: 2015-09-02
福建省力菲克药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a curcumin cyclodextrin inclusion compound, which solves the problem that the organic solvent residue and degradation product ratio are higher in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of the cyclodextrin inclusion compound of embodiment 1 curcumin

[0022] Stir in 100ml of water at a speed greater than 200r / min. Under stirring, use NaOH to adjust the pH of the solution to 12, add 25g of β-cyclodextrin until the dispersion is uniform, and control the temperature of the solution system by passing water through the cladding pot Slowly add 1g of curcumin into the liquid under stirring condition at 25-30°C, and continue to stir for 6 hours after the addition is completed. Immediately neutralize with HCl after the reaction, adjust the pH value to 6.8-7.0, and stir well after the neutralization Immediately spray-dry to obtain an orange-yellow loose powder, which is a cyclodextrin inclusion compound of curcumin. Through HPLC detection, the inclusion compound contains 0.87 g of curcumin, and the inclusion rate is 87%.

Embodiment 2

[0023] The preparation of the cyclodextrin inclusion compound of embodiment 2 curcumin

[0024] Stir in 100ml of water at a speed greater than 200r / min. Under stirring, use NaOH to adjust the pH of the solution to 12, add 30g of 2-hydroxypropyl-β-cyclodextrin until the dispersion is uniform, and pass water through the interlayer of the clathrate pot Method Control the temperature of the solution system at 20-25°C, slowly add 1 g of curcumin into the liquid under stirring conditions, and continue to stir for 5 hours after the addition is completed, neutralize with HCl immediately after the reaction, adjust the pH value to 6.8-7.0, Stir evenly after neutralization and immediately spray dry to obtain an orange-yellow loose powder, which is a cyclodextrin inclusion compound of curcumin. According to HPLC detection, the inclusion compound contains 0.93 g of curcumin, and the inclusion rate is 93%.

Embodiment 3

[0025] The preparation of the cyclodextrin inclusion compound of embodiment 3 curcumin

[0026] Stir in 100ml of water at a speed greater than 200r / min. Under stirring, use NaOH to adjust the pH of the solution to 12, add 35g of hydroxyethyl-β-cyclodextrin until it is evenly dispersed, and pass water through the cladding pot. The temperature of the solution system is controlled at 30-35°C. Slowly add 1g of curcumin into the liquid under stirring conditions. After the addition, continue stirring for 8 hours. Stir evenly after finishing and immediately spray dry to obtain an orange-yellow loose powder, which is a cyclodextrin inclusion compound of curcumin. Through HPLC detection, the inclusion compound contains 0.84 g of curcumin, and the inclusion rate is 84%.

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Abstract

The invention discloses a curcumin cyclodextrin clathrate compound which is composed of the following components in parts by mass: 1 part of curcumin and 1-100 parts of cyclodextrin. The invention further discloses a preparation method of the curcumin cyclodextrin clathrate compound. Curcumin directly dissolves in alkaline solution in a lucifugal environment, and the clathration process adopts the low-temperature technology, so that the degradation of curcumin is avoided, and the application of organic solvent is also avoided; the cyclodextrin has the cannular molecular structure, and the curcumin comprising the liposoluble constituent is included in cyclodextrin to form a molecular capsule, so that the water solubility and biocompatibility are enhanced; the clathration of cyclodextrin is utilized to include curcumin so as to improve the stability and bioavailability.

Description

technical field [0001] The invention belongs to the technical field of medicine and health food, and specifically relates to a curcumin cyclodextrin inclusion compound. The invention also discloses a preparation method of the curcumin cyclodextrin inclusion compound. Background technique [0002] Curcumin is a chemical component extracted from the rhizomes of some plants in Zingiberaceae and Araceae. It is a rare pigment with diketones in the plant kingdom, and it is a diketone compound. Curcumin is orange-yellow crystalline powder with slightly bitter taste. Insoluble in water. Medical research shows that curcumin has the effects of lowering blood fat, lowering blood sugar, anti-tumor, anti-inflammatory, choleretic, and anti-oxidation. [0003] Curcumin is sensitive to light and is easily degraded by light. Curcumin is insoluble in water and easily soluble in alkaline solution, but it is sensitive to temperature in alkaline solution and is easy to degrade at high temperat...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/12A61P3/06A61P3/10A61P35/00A61P29/00A61P1/16A61P39/06
Inventor 林冠雄许友赤
Owner 福建省力菲克药业有限公司
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