Injectable bone repair material and preparation method therefor

A bone repair, injection-type technology, applied in medical science, prosthesis, etc., can solve the problems of open implantation, limited material extraction, increased trauma, etc., to achieve the effect of simple method, less trauma, and fewer complications

Inactive Publication Date: 2015-09-16
HANGZHOU FIRST PEOPLES HOSPITAL
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Problems solved by technology

Autologous cancellous bone grafting, as the gold standard for the treatment of delayed union or nonunion of bone, can provide the basic elements required for bone repair, including supplement

Method used

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  • Injectable bone repair material and preparation method therefor
  • Injectable bone repair material and preparation method therefor

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Embodiment Construction

[0012] Implantation of cells expanded in vitro requires suitable carrier materials, and simple injection of cell suspension will diffuse quickly and cannot exert therapeutic effect. The invention provides an injectable autologous bone repair material, which comprises a scaffold material and seed cells, and the seed cells and the scaffold material are compounded to form a compound with a three-dimensional structure and osteogenic activity, the scaffold material is fibrin glue, and the The seed cells were cultured human bone marrow stromal stem cells. Fibrin glue simulates the final stage of the human body's own blood coagulation reaction. When the components are mixed, thrombin hydrolyzes fibrinogen into fibrin monomers, and aggregates under the action of factor XIII to form stable fibrin polymers.

[0013] The injectable autologous bone repair material mainly includes two components, (1) prepare the main glue solution containing BMSCs, and the final concentration of cells is 2...

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Abstract

The invention discloses an injectable bone repair material and a preparation method therefor, and belongs to the technical field of constructing artificial internal organs through a tissue engineering method in biomedical engineering. The injectable bone repair material is a composite body composed of a support material and seed cells, with a stereo structure and physiological activity. Injectable fibrin glue is employed as the support materials, and human autologous marrow matrix stem cells are cultured to obtain seed cells. The seed cells are human marrow matrix stem cells. The histocompatibility of the human marrow matrix stem cells and fibrin glue is good, and the composite constructed bone repair material can cure clinic bone ununion successfully. The repair material integrates advantages of a cell therapy and the support material, a new means is employed, a bone ununion therapeutic method with minimal injury and complications is provided, and the repair material has wide clinic application prospects.

Description

technical field [0001] The invention belongs to the technical field of constructing artificial organs with tissue engineering methods in biomedical engineering, and in particular relates to an injectable bone repair material and a preparation method thereof. Background technique [0002] Post-traumatic nonunion is common in clinical practice, and its treatment is still difficult. Usually, measures such as replacement of internal fixators and bone grafting are taken according to the possible cause of nonunion. There are many deficiencies such as secondary damage in these methods. Autologous bone marrow injection is used to treat bone nonunion. In some patients and parts, it is difficult to inject a sufficient amount of bone marrow to affect the therapeutic effect. Concentrating bone marrow requires expensive special equipment, and collecting hundreds of milliliters of bone marrow at multiple points is difficult for patients to accept. As a major frontier topic in the field ...

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Application Information

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IPC IPC(8): A61L27/22A61L27/38
Inventor 朱六龙姚旺祥边振宇李茂强何齐芳季成田飞何帆王雪鹏范小良周少波
Owner HANGZHOU FIRST PEOPLES HOSPITAL
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