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A kind of pH responsive sodium alginate nanogel and preparation method thereof

A technology of sodium alginate and nanogel, which is applied in aerosol delivery, liquid delivery, ointment delivery, etc. It can solve the problems of poor quality reliability, low output, high cost, etc., and achieves controllable gel size and excellent preparation process. The effect of simplicity and good application prospects

Inactive Publication Date: 2018-01-19
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these chemicals are difficult to remove before final use, thus affecting health
Moreover, this multi-step preparation strategy often causes problems such as environmental load, high cost, low yield, and poor quality reliability.

Method used

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  • A kind of pH responsive sodium alginate nanogel and preparation method thereof
  • A kind of pH responsive sodium alginate nanogel and preparation method thereof
  • A kind of pH responsive sodium alginate nanogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] In a three-neck flask, add 0.2mL 5mg / mL sodium alginate aqueous solution, dilute it with ultrapure water, and stir for 0.5h; then, under ultrasonic conditions, slowly add 0.225mL 0.01mol / L calcium chloride solution dropwise solution, dilute to a final volume of 20.0 mL with ultrapure water, and stir for 2 h. The obtained crude product solution was dialyzed four times in ultrapure water, and the molecular weight cut-off of the dialysis bag used was 10KDa to obtain an aqueous solution of nanogel, which was freeze-dried to obtain flocculent sodium alginate nanogel.

[0029] The average particle size and potential of the obtained nanogels are as figure 1 As shown, they are 350-375nm and -31.2mV respectively.

Embodiment 2

[0031] In a three-neck flask, add 0.2mL 5mg / mL sodium alginate aqueous solution, dilute it with ultrapure water, and stir for 0.5h; then, under ultrasonic conditions, slowly add 0.225mL 0.01mol / L calcium chloride solution dropwise solution, dilute to a final volume of 13.3 mL with ultrapure water, and stir for 2 h. The obtained crude product solution was dialyzed four times in ultrapure water, and the molecular weight cut-off of the dialysis bag used was 10KDa to obtain an aqueous solution of nanogel, which was freeze-dried to obtain flocculent sodium alginate nanogel.

[0032] The average particle size and potential of the obtained nanogels are as figure 1 As shown, they are 300-355nm and -34.2mV respectively.

Embodiment 3

[0034] In the three-neck flask, add 0.4mL 5mg / mL sodium alginate aqueous solution, dilute it with ultrapure water, and stir for 0.5h; then, under ultrasonic conditions, slowly add 0.45mL 0.01mol / L calcium chloride solution dropwise solution, dilute to a final volume of 20.0 mL with ultrapure water, and stir for 2 h. The obtained crude product solution was dialyzed four times in ultrapure water, and the molecular weight cut-off of the dialysis bag used was 10KDa to obtain an aqueous solution of nanogel, which was freeze-dried to obtain flocculent sodium alginate nanogel.

[0035] The average particle size and potential of the obtained nanogels are as figure 1 As shown, they are 170-210nm and -37.2mV respectively.

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Abstract

The invention discloses a pH-responsive sodium alginate nanogel and a preparation method thereof, including: (1) dissolving and mixing sodium alginate and antitumor drugs; Reaction and constant volume; (3) dialysis, purification, and freeze-drying to obtain flocculent sodium alginate nanogel products. The invention has the advantages of simple process, safe operation and mild reaction conditions, and the gel with negative charge on the surface and particle size range of 170-700nm can be obtained by controlling the concentration of reactants. The gel with a particle size of 170-220nm presents a regular spherical structure, can load a variety of hydrophilic anti-tumor drugs, has a significant drug-controlled release effect, can effectively inhibit the growth of tumors, and has the potential to be applied in the field of cancer treatment and broad market prospects.

Description

technical field [0001] The invention relates to a pH-responsive sodium alginate nanogel and a preparation method thereof, belonging to the technical field of nanomaterials and their preparation. Background technique [0002] Nanogel refers to a three-dimensional network structure formed by chemical or physical cross-linking of polymers with nanoscale (10-1000 nm) size. As a drug carrier, nanogel can significantly improve the bioavailability of drugs and the delivery and release performance of drugs in vivo. It is a kind of safe system with potential biomedical application value. [0003] In the past decade, multiple stimuli-responsive drug delivery systems have been rapidly developed in the research of cancer diagnosis and therapy. It is well known that the pH value of the tumor extracellular environment (pH ~ 6.5) is lower than that of blood (pH ~ 7.4), and the pH value of endosomes and lysosomes (pH 5.0 ~ 5.5) is lower. Therefore, the design of pH-responsive nanogels, su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K9/06C08J3/075C08J3/24C08L5/04C08K3/16C08K3/26
Inventor 喻发全薛亚楠夏晓洋喻波龙思会
Owner WUHAN INSTITUTE OF TECHNOLOGY
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