Composite material of functional mesoporous silica loaded drug and siRNA, preparation and application thereof in preparation of anticancer drugs

A technology of mesoporous silica and silica, which is applied in the direction of drug combination, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problem that no functionalized mesoporous silica is found Systematic cancer treatment and other issues, to achieve the effect of improving gene silencing efficiency, increasing enrichment, and increasing accumulation
CN105056239AInactive Publication Date: 2015-11-18JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2015-11-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

Belonging to the fields of functional material loaded drugs and gene technologies, the invention discloses a composite material of a functional mesoporous silica loaded drug and siRNA, a preparation method and application thereof in preparation of anticancer drugs. The composite material is prepared by the method comprising the steps of: adding mesoporous silica into a 3-mercaptopropyl trimethoxysilane solution, conducting heating reaction and separation to obtain thiolated mesoporous silica, dispersing the thiolated mesoporous silica into a 2, 2-dithiodipyridine solution, and carrying out heating reaction to obtain disulfide bond modified mesoporous silica, adding the disulfide bond modified mesoporous silica into a doxorubicin water solution, then adding thiolated siRNA, and conducting separation, thus obtaining the composite material of the functional mesoporous silica loaded drug and siRNA. The composite material provided by the invention can be applied to preparation of anticancer drugs, can load drugs into cells, significantly improves the enrichment amount of drugs in cells, plays a good mesopore blocking role, and reaches the effect of silencing gene when released in cells.
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Description

technical field

[0001] The invention belongs to the technical field of functional materials loaded with drugs and genes, and in particular relates to a composite material of functionalized mesoporous silica loaded with drugs and siRNA, a preparation method thereof and an application in preparing anticancer drugs. Background technique

[0002] In recent years, the domestic anti-cancer market has shown a growing trend, and anti-cancer drugs have jumped to the second place in hospital medication, only lower than anti-infective drugs. At present, the means of treating cancer mainly include surgical treatment, radiotherapy and chemical drug treatment, but these treatment methods are easy to damage normal cells and immune cells while killing cancer cells, lack of selectivity, and cause a series of toxic side effects , some of the more serious adverse reactions will threaten the lives of patients.

[0003] Currently, the treatment of localized and spread cancers mainly relies on c...

Claims

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