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Application of FAM3C antisense nucleotide in preparation of drugs for inhibiting epithelial ovarian cancer cell invasion and metastasis

An antisense nucleotide, ovarian cancer cell technology, applied in the field of tumor biotherapy, can solve problems such as lack of specificity, and achieve the effects of improving survival rate and prognosis, inhibiting migration and invasion ability, and reducing progression and malignancy.

Active Publication Date: 2015-11-25
HARBIN MEDICAL UNIVERSITY
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Problems solved by technology

[0006] The current clinical treatment for epithelial ovarian cancer includes surgical resection or tumor reduction, supplemente

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  • Application of FAM3C antisense nucleotide in preparation of drugs for inhibiting epithelial ovarian cancer cell invasion and metastasis
  • Application of FAM3C antisense nucleotide in preparation of drugs for inhibiting epithelial ovarian cancer cell invasion and metastasis
  • Application of FAM3C antisense nucleotide in preparation of drugs for inhibiting epithelial ovarian cancer cell invasion and metastasis

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Abstract

The invention discloses application of FAM3C antisense nucleotide in the preparation of drugs for inhibiting epithelial ovarian cancer cell invasion and metastasis. An antisense nucleotide of FMA3C is shown in SEQ ID NO.1 or SEQ ID NO.2. For ovarian cancer cell lines with actively expressed FAM3C, expression of FAM3C genes in epithelial ovarian cancer cells is stably silenced through the antisense nucleotide, epithelial-mesenchymal transition of the epithelial ovarian cancer cells is specifically blocked, the ability of cancer cells to invade and metastasize can be decreased, tumors are less malignant, and survival rate and prognosis of a patient are increased. By applying the antisense nucleotide of FAM3C to the preparation of drugs for inhibiting epithelial ovarian cancer cell invasion and metastasize, novel drugs and targeted therapies can be provided for biological treatment of epithelial ovarian cancer, specificity of cancer therapy is improved, and novel strategies are provided for the treatment of metastatic ovarian cancer.

Description

technical field [0001] The present invention relates to a new application of antisense nucleotides of sequence similarity protein family 3 member C (FAM3C), in particular to the application of antisense nucleotides of FAM3C in the preparation of drugs for inhibiting the invasion and metastasis of epithelial ovarian cancer cells, belonging to The technical field of tumor biotherapy. Background technique [0002] The death rate of ovarian cancer ranks first among all gynecological tumors, and it is a disease that seriously endangers women's lives and health. Ovarian cancer is divided into epithelial ovarian cancer, sex cord-stromal ovarian cancer, germ cell ovarian cancer and metastatic ovarian cancer according to its source. Epithelial ovarian cancer is the most common type of ovarian cancer, accounting for about 90% of ovarian cancer cases. Due to the lack of obvious clinical manifestations in the early stage of ovarian cancer, it is often delayed until invasion and metast...

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Application Information

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IPC IPC(8): A61K48/00A61P35/00
Inventor 张春玉包砚涛由佳刘畅王立群董科显白静关荣伟傅松滨
Owner HARBIN MEDICAL UNIVERSITY
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