Vascular endothelial growth factor fusion protein

A growth factor and fusion protein technology, applied in the direction of anti-growth factor immunoglobulin, growth factor/growth regulator, fusion polypeptide, etc., can solve the problems of VEGF abnormal angiogenesis, etc., to achieve enhanced binding affinity, excellent migration and invasion, Inhibition of growth and proliferation
CN107312093AActive Publication Date: 2017-11-03KOREA PRIME PHARM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KOREA PRIME PHARM
Publication Date
2017-11-03

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Abstract

The present invention relates to a vascular endothelial growth factor fusion protein. The present invention relates to a fusion protein binding to a vascular endothelial growth factor (VEGFR) and / or a placental growth factor (PLGF). The fusion protein of the present invention comprises (a) a Fc domain of IgG1, wherein two heavy chains are linked by disulfide bond, and (b) four immunoglobulin domain2s of the VEGFR1, wherein two immunoglobulin domain2s are sequentially fused to each heavy chain of the Fc domain of (a). The present fusion protein has excellent activities of inhibiting cell migration and cell invasion, and has highly enhanced growth inhibition effects to various carcinomas and fibroblasts. Therefore, the fusion protein of the present invention can be used in the preparation of an agent for treating cancers or ocular diseases.
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Description

technical field

[0001] The invention relates to a vascular endothelial growth factor receptor (VEGFR) fusion protein, which is used for preparing a medicament (agent) for treating cancer or eye diseases. The fusion protein of the present invention is a multivalent bispecific antibody in which the extracellular domain of VEGFR is fused to the Fc region of an immunoglobulin-like domain. Background technique

[0002] Vascular endothelial growth factor (VEGF) is a signaling protein that plays an important role in promoting both angiogenesis and angiogenesis. VEGF functions as part of a system that restores and supplies oxygen to tissues when blood circulation is poor. A well-known function of VEGF is to generate new blood vessels to bypass blocked blood vessels during embryonic development, at the site of injury, in muscle after exercise, and in vessel formation.

[0003] However, increased amounts of VEGF may cause abnormal angiogenesis. In particular, angiogenesis is associ...

Claims

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