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Ameliorating agent for chronic obstructive pulmonary disease
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A technology for chronic obstructive pulmonary disease and superoxide, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, respiratory diseases, etc., to achieve specific effects and improve symptoms
Inactive Publication Date: 2015-12-09
LTT BIO PHARMA
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[0012] From the above point of view, various COPD improving agents or improving methods have been proposed so far (for example, Patent Documents 11 and 12), but the present situation is that the appearance of a more excellent COPD improving agent is expected
Method used
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preparation example Construction
[0083] The preparation of the COPD improving agent provided by the present invention can be carried out by using PC-SOD and sucrose by a well-known and customary method in pharmacy. It should be noted that PC-SOD used in the preparation composition of the present invention is preferably in a solution state, frozen state, or freeze-dried state.
[0084] As one of the ways, the COPD improving agent provided by the present invention can be preferably administered in the form of injection. Injections are preferably in the form of solutions, suspensions, emulsions, and time-dissolving solid preparations, and these preparations can be prepared according to the methods described in the Japanese Pharmacopoeia General Rules for Preparations.
[0085] In addition, as another mode, the COPD improving agent provided by the present invention can be preferably administered in the form of an inhalation.
[0086] The inhalant refers to a pharmaceutical composition used to reach the trachea, br...
preparation example 1
[0124] Preparation Example 1: Intravenous Injection
[0125] 1% (w / w) PC-SOD, 10% (w / w) sucrose, and 0.05% (w / w) benzalkonium chloride were dissolved in 5% xylitol aqueous solution, and freeze-dried. 0.5% carboxymethylcellulose or water for injection filled in a separate vial was added to the obtained freeze-dried preparation to obtain an intravenous injection preparation.
Embodiment 2
[0126] Example 2: Inhalation
[0127] Liquids for Inhalation (1)
[0128] A solution for inhalation was prepared by dissolving 1% (w / w) PC-SOD, 10% (w / w) sucrose, and 0.05% (w / w) benzalkonium chloride in 5% xylitol aqueous solution.
[0129] Liquids for Inhalation (2)
[0130] With 1% (w / w) PC-SOD, 10% (w / w) sucrose, 0.05% (w / w) benzalkonium chloride, 10% (w / w) polyethylene glycol, 20% (w / w) w) propylene glycol, and the rest of purified water to prepare a liquid for inhalation.
[0131] powder for inhalation
[0132] A powder for inhalation was prepared with 5% (w / w) PC-SOD, the remainder sucrose (finely powdered).
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Abstract
An ameliorating agent for chronic obstructive pulmonary disease (COPD) containing as an active ingredient a lecithinized superoxide dismutase represented by the following general formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒSOD'(Q-B) m €ƒ€ƒ€ƒ€ƒ€ƒ(I) (in the formula SOD' represents a residue of the superoxide dismutase; Q represents a chemical crosslinking; B represents a residue without a hydrogen atom of a hydroxyl group of lysolecithin having the hydroxyl group at the 2-position of glycerol; m is the average number of bonds of lysolecithin to one molecule of superoxide dismutase and represents an integer of 1 or more). The ameliorating agent for COPD is intravenously administered or inhalation-administrated.
Description
[0001] This application is a divisional application, the international application number of the original application is PCT / JP2010 / 053317, the Chinese national application number is 201080011243.5, the application date is March 2, 2010, and the invention name is "Chronic Obstructive Pulmonary Disease Improving Agent" . technical field [0002] The present invention relates to the application of lecithinated superoxide dismutase as an active ingredient in the preparation of an agent for improving chronic obstructive pulmonary disease. SOD) is an agent for improving chronic obstructive pulmonary disease as an active ingredient. Background technique [0003] Superoxide dismutase (hereinafter, sometimes abbreviated as SOD) is a physiologically active protein extracted from the blood of cattle by Huber et al. in 1965 as an anti-inflammatory protein. It has been clarified that it can specifically remove one of the active oxygen species Superoxide anion (O 2 - ). In organisms,...
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Application Information
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