Synthetic method of oxidized cellulose

A technology of oxidized cellulose and synthesis method, which is applied in the field of oxidized cellulose synthesis, can solve the problems of low synthesis efficiency, low carboxyl content of oxidized cellulose, long oxidation time, etc., achieve high carboxyl content, promote deep oxidation, and improve reaction performance effect

Inactive Publication Date: 2015-12-09
JIANGSU LANWAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the selective oxidation technology used in the prior art to oxidize cellulose has a relatively long oxidation time. For example, Wang Li et al. 3 / H 3 PO 4 -NaNO 2 Oxidation system oxidizes cellulose, the reaction time is 96 hours, and the carboxylation degree of the obtained oxidized cellulose is 18.46%; for example, Chinese patent (CN101724078A) uses nitric acid or nitrite as an oxidant to oxidize cellulose, and the reaction temperature is 20-30°C The carboxyl content in the oxidized cellulose obtained after 12 hours of reaction under high temperature is 8%. For example, the Chinese patent (CN103255663A) adopts a pretreatment method to improve the efficiency of oxidized cellulose, which is obtained by using TEMPO catalytic oxidation technology at room temperature for 6 hours. Carboxyl content of oxidized cellulose increased by 17.7%
It can be seen that the oxidation time of cellulose in the prior art is very long, the synthesis efficiency is low, and the carboxyl content of the obtained oxidized cellulose is relatively low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 20g of absorbent cotton and put it into a container, add 200mL of NaOH solution with a concentration of 7.9wt%, and ultrasonicate for 6 hours to obtain a cellulose slurry; rinse with deionized water until the slurry is neutral, and dry it for later use; take 10g of pretreated Put the absorbent cotton in the container, add 30g of NaClO 4 and 40g of K 2 FeO 4 , then add an appropriate amount of deionized water and stir at room temperature, the amount of deionized water is such that NaClO 4 and K 2 FeO 4 Dissolve completely; then add NaAc solution with a concentration of 0.038g / mL dropwise to the mixture, control the pH value of the reaction to 10.5, the reaction temperature to 30°C, and the reaction time to 1h; clean and centrifuge the reacted product until the washed The pH of the waste liquid is 6-7; the cleaned product is finally vacuum-dried at a drying temperature of 80° C. for 3 hours. The carboxyl content was measured to be 21.6%.

Embodiment 2

[0021] Take 20g of absorbent cotton and put it into a container, add 200mL of NaOH solution with a concentration of 7.9wt%, and ultrasonicate for 6 hours to obtain a cellulose slurry; then rinse it with deionized water until the slurry is neutral, and dry it for later use; take 10g after pretreatment Put the absorbent cotton in the container, add 40g of NaClO 4 and 50g of K 2 FeO 4 , then add an appropriate amount of deionized water to stir at room temperature, the amount of deionized water is such that NaClO 4 and K 2 FeO 4 Dissolve completely; then add NaAc solution with a concentration of 0.041g / mL dropwise to the mixture, control the pH value of the reaction to 11.3, the reaction temperature is 35°C, and the reaction time is 2h; the reacted product is cleaned and centrifuged until the washed product The pH of the waste liquid is 6-7; the cleaned product is finally vacuum-dried at a drying temperature of 80° C. for 3 hours. The carboxyl content was measured to be 24.7%...

Embodiment 3

[0023] Take 20g of degreased cotton gauze and put it into a container, add 200mL of NaOH solution with a concentration of 9.0wt%, and ultrasonicate for 4 hours to obtain a cellulose slurry; then rinse it with deionized water until the slurry is neutral, and dry it for later use; take 10g for pretreatment After the absorbent cotton gauze is placed in the container, add 40g of NaClO 4 and 50g of K 2 FeO 4 , then add an appropriate amount of deionized water to stir at room temperature, the amount of deionized water is such that NaClO 4 and K 2 FeO 4 Completely dissolve; then add NaAc solution with a concentration of 0.044g / mL dropwise to the mixture, control the pH value of the reaction to 11.8, the reaction temperature is 40°C, and the reaction time is 2h; the product after the reaction is cleaned and centrifuged until the product after cleaning The pH of the waste liquid is 6-7; the cleaned product is finally vacuum-dried at a drying temperature of 80° C. for 3 hours. The ...

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Abstract

The invention discloses a synthetic method of oxidized cellulose. According to the method, firstly, cellulose materials are pretreated through an NaOH or LiOH solution by combining an ultrasonic technology; then, an NaClO4 and K2FeO4 oxidation system is used for further oxidizing the materials through regulating the pH values in the mixed material via NaAc; the oxidation temperature is 30 to 42 DEG C; the oxidization time is 1 to 3h; finally, an oxidized product is cleaned and dried. The method has the advantages that the cellulose oxidization time can be greatly shortened; in addition, the obtained oxidized cellulose has high-content carboxyl; the content of the carboxyl can reach 21.6 percent to 35.8 percent; the oxidized cellulose belongs to a medical material with better application prospects.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a method for synthesizing oxidized cellulose. Background technique [0002] As a kind of cellulose derivative, oxidized cellulose is widely used because of its good biocompatibility, biodegradability, environmental friendliness and non-toxicity. For example, in the medical industry, as medical absorbable hemostatic gauze, medical absorbable surgical sutures, medical anticoagulants, artificial organ materials, blood separation membranes, blood pumps, etc.; in addition, it can also be used in the tobacco industry for Preparation of activated carbon materials, used in photographic paper ion exchange materials, etc. [0003] At present, the oxidation reaction of cellulose can be divided into two categories: non-selective oxidation and selective oxidation. The situation of non-selective oxidation is more complicated. For example, in the production of viscose fiber, gene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B15/02
Inventor 章祥庆唐海健
Owner JIANGSU LANWAN BIOTECH
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