A kind of absorbable surgical suture and preparation method thereof

A surgical suture and wet spinning technology, which is applied in the fields of surgery, medical science, textiles and papermaking, etc., can solve the problems of complex preparation process, incompatibility of biocompatibility and mechanical properties, etc., achieve smooth surface, avoid dismantling The effect of thread pain, good toughness and tensile strength

Active Publication Date: 2018-05-22
SHENZHEN BRIGHT WAY NOVEL BIO MATERIALS TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to propose an absorbable surgical suture and its preparation method, so as to solve the technical problems in the above-mentioned prior art that the preparation process is complex and the biocompatibility and mechanical properties cannot be achieved at the same time.

Method used

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  • A kind of absorbable surgical suture and preparation method thereof
  • A kind of absorbable surgical suture and preparation method thereof

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preparation example Construction

[0027] A kind of preparation method of absorbable surgical suture that the present invention proposes, comprises the following steps:

[0028] S1. According to the solid-liquid ratio of 1.0:100~5.0:100g / ml, the degree of deacetylation is greater than 60%, and the molecular weight is greater than 0.5×10 6 The squid cartilage chitosan is dissolved to obtain the spinning stock solution;

[0029] S2. Wet spinning, drying and stretching the filtered and defoamed spinning stock solution to obtain absorbable surgical sutures.

[0030] Wherein, the preparation of squid cartilage chitosan in step S1 comprises:

[0031] S11. Dissolve squid cartilage β-chitin or squid cartilage chitosan in a NaOH solution with a mass percent concentration of 30% to 40% according to a solid-liquid ratio of 5.0:100 to 25:100 g / ml, at 50 to 80 After stirring at ℃ for 1-6 hours, filter to obtain the filter residue;

[0032] S12, washing the filter residue obtained in step S11 until neutral and then drying...

Embodiment 1

[0055] A kind of preparation method of absorbable surgical suture that the present invention proposes, comprises the following steps:

[0056] S1, 2.0g squid cartilage chitosan (DD=75.70%, MW=1.20×10 6 ) powder was dissolved in 50ml of acetic acid solution with a mass percentage concentration of 2%, stirred for 2 hours under the action of a magnetic stirrer, and after being completely dissolved, the spinning stock solution was obtained;

[0057] S2. After filtering and defoaming the spinning stock solution, input the spinneret with an inner diameter of 0.8mm through a metering pump, and squeeze the spinning stock solution into the coagulation bath with a pressure of 40N to obtain chitosan monofilament; wherein, each group of the coagulation bath The mass percent of points comprises: 4% sodium hydroxide, 2% ethanol, and the rest are deionized water;

[0058] S3. Chitosan monofilaments were soaked in deionized water and washed until neutral, then stretched 10N at room temperatu...

Embodiment 2

[0064] A kind of preparation method of absorbable surgical suture that the present invention proposes, comprises the following steps:

[0065] S1, 2.2g squid cartilage chitosan (DD=79.99%, MW=1.15×10 6 ) powder was dissolved in 50ml of acetic acid solution with a mass percentage concentration of 2%, stirred for 2 hours under the action of a magnetic stirrer, and after being completely dissolved, the spinning stock solution was obtained;

[0066] S2. After filtering and defoaming the spinning stock solution, input the spinneret with an inner diameter of 0.5mm through a metering pump, and squeeze the spinning stock solution into the coagulation bath with a pressure of 60N to obtain chitosan monofilament; wherein, each group of the coagulation bath The mass percent of points comprises: sodium hydroxide 6%, ethanol 1%, all the other are deionized water;

[0067] S3. Chitosan monofilaments were soaked in deionized water and washed until neutral, then stretched 10N at room temperat...

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Abstract

Disclosed are an absorbable surgical suture and a preparation method therefor. The preparation method comprises the following steps: S1, dissolving squid cartilage chitosan to obtain a spinning solution, the deacetylation degree of the squid cartilage chitosan being greater than 60%, and the molecular weight of the squid cartilage chitosan being greater than 0.5*106; and S2, spinning the spinning solution and then drying to obtain the absorbable surgical suture. The absorbable surgical suture prepared by the method has a mechanical property reaching the requirements of clinical application, can be gradually absorbed by a human body and effectively promote the healing of a wound tissue, and has a better application prospect.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to an absorbable surgical suture and a preparation method thereof. Background technique [0002] Surgical sutures have a long history and can be divided into non-absorbable surgical sutures and absorbable surgical sutures according to their different properties. The biggest disadvantage of non-absorbable surgical sutures is that they need to be removed after the wound has healed, there are varying degrees of tissue reactions, and the sutures are easy to leave scars. Therefore, they are limited in many surgical operations and are especially not suitable for suturing internal tissues. Since the 20th century, many developed countries in the world have begun to study absorbable surgical sutures, such as catgut, silk thread and PGA thread, which have been used in actual clinical practice. Absorbable surgical sutures can be degraded and absorbed in the human body. The pain caused by...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F9/00C08B37/08A61L17/08
CPCA61L17/08D01F9/00
Inventor 吴奕光薛清辉江长兵黎剑辉吴灿光
Owner SHENZHEN BRIGHT WAY NOVEL BIO MATERIALS TECH CO LTD
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