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A kind of preparation method of small golden pill

A material preparation and formulation technology, applied to medical preparations containing active ingredients, pill delivery, pharmaceutical formulations, etc., can solve the problems of poor mixing uniformity of Xiaojin pill powder, difficulty in ensuring quality uniformity, and obvious odor differences, etc., to achieve The effect of low cost, guaranteed dosage and quality, and convenient preparation

Active Publication Date: 2019-05-07
CHENGDU JIUZHITANG JINDING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in the production process, due to the properties and dosage ratio of the above-mentioned medicinal materials, the mixing uniformity of Xiaojin Wan powder is not good, and the quality uniformity is difficult to guarantee, which leads to uneven color, obvious difference in smell and batch-to-batch difference in Xiaojin Wan products. major issues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: a kind of preparation method of small golden pill, it comprises the following steps:

[0023] S1. Prepare materials: prepare materials according to the following formula by weight: artificial musk: 1 part, wood turtle: 8 parts, made Aconitum aconiti: 9 parts, sweetgum: 9 parts, made frankincense: 4 parts, made myrrh: 4 parts , Stir-fried Wulingzhi with vinegar: 9 parts, wine angelica: 4 parts, earthworm: 9 parts, fragrant ink: 0.5 parts;

[0024] S2. Moist heat sterilization: put the raw materials of wine angelica, vinegar fried Wulingzhi, Zhicaowu, and Dilong four flavors in a sterilization cabinet for sterilization and drying. The sterilization temperature is 110°C. The sterilization time is 10 minutes, and the drying time is 25 minutes;

[0025] S3. Crushing and sieving: Grinding the artificial musk into a fine powder; putting the wine angelica sinensis sterilized in step S2, stir-fried Wulingzhi with vinegar, Zhicaowu and Dilong in a chabatian type gr...

Embodiment 2

[0029] Embodiment 2: a kind of preparation method of small golden pill, it comprises the following steps:

[0030] S1. Prepare materials: prepare materials according to the following formula by weight: artificial musk: 2 parts, wood turtle: 11 parts, aconitum: 11 parts, maple gum: 11 parts, frankincense: 7 parts, myrrh: 6 parts , Stir-fried Wulingzhi with vinegar: 11 parts, wine angelica: 6 parts, earthworm: 11 parts, fragrant ink: 1.5 parts;

[0031] S2. Moist heat sterilization: put the raw materials of wine angelica, vinegar fried Wulingzhi, Zhicaowu, and Dilong four flavors in a sterilization cabinet for sterilization and drying. The sterilization temperature is 130°C. The sterilization time is 20 minutes, and the drying time is 35 minutes;

[0032] S3. Crushing and sieving: Grinding the artificial musk into a fine powder; putting the wine angelica sinensis sterilized in step S2, stir-fried Wulingzhi with vinegar, Zhicaowu and Dilong in a chabatian type grinder for pulver...

Embodiment 3

[0036] Embodiment 3: a kind of preparation method of small golden pill, it comprises the following steps:

[0037] S1. Prepare materials: Prepare materials according to the following formula by weight: artificial musk: 1.3 parts, wood turtle: 9 parts, made Aconitum aconiti: 10 parts, sweetgum balm: 10 parts, made frankincense: 5 parts, made myrrh: 5 parts , Stir-fried Wulingzhi with vinegar: 10 parts, wine angelica: 4.5 parts, earthworm: 10 parts, fragrant ink: 0.7 parts;

[0038] S2. Moist heat sterilization: put the raw materials of wine angelica, vinegar fried Wulingzhi, Zhicaowu, and Dilong four flavors in a sterilization cabinet for sterilization and drying. The sterilization temperature is 115°C. The sterilization time is 12 minutes, and the drying time is 28 minutes;

[0039] S3. Crushing and sieving: Grinding the artificial musk into a fine powder; putting the wine angelica sinensis sterilized in step S2, stir-fried Wulingzhi with vinegar, Zhicaowu and Dilong in a cha...

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Abstract

The invention discloses a preparation method of Xiaojin pills, wherein the preparation method comprises steps of material preparing, moist heat sterilizing, crushing and sieving, total-mixing, medicine refining and drying. According to the preparation method disclosed by the invention, momordica cochinchinensis, pine-soot ink, processed frankincense, processed myrrh and resina liquidamberis are crushed by virtue of a jet mill with a high crushing fineness; by constantly conducing the crushing process at low temperature, a cohesion phenomenon in the resina liquidamberis, frankincense and like medicinal materials is avoided and the medicinal materials are easy to sieve; in combination with viscosities of the resina liquidamberis, the frankincense, the myrrh and the like in a prescription, the dosage of starch is reduced; by adding proper amount of a disintegrating agent to a pelleting process, the pills, before being taken, are unnecessary to be broken and are ready to be taken directly anytime and anywhere, and the pills are disintegrated into blocks in water in gastrointestinal tract, so that burden on the gastrointestinal tract is not increased and a good slow-release effect is achieved; and the method disclosed by the invention is simple to operate, convenient in preparation, low in cost and applicable to industrial large-scale production.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation method of Xiaojin Wan. Background technique [0002] The preparation process of traditional Chinese medicine pills mainly includes crushing-mixing-pill making links, among which mixing is the key link that determines the "quality uniformity" of pills. Because the traditional Chinese medicine pills are used as whole powder, the source of the powder is complex, and the properties vary greatly, such as wide particle size distribution, different shapes, great density differences, strong adhesion, strong cohesion, agglomeration and hardening when heated, oil spillage after crushing oil drugs, etc. , has a serious impact on the uniformity of powder mixing, making it difficult to guarantee the quality uniformity of traditional Chinese medicine pills, which in turn affects the clinical effect. [0003] Xiaojin Wan is recorded in the "Chinese Pharmacopoeia" (2010 edition...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/714A61P15/14A61K35/62A61K35/55A61K35/24
Inventor 张宁蒋丽王洪涛吕春艳郑飞宋敏甘灿
Owner CHENGDU JIUZHITANG JINDING PHARMA
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