Application of scutellaria baicalensis in preparing medicament for treating ascites due to cirrhosis

Abstract

An application of scutellaria baicalensis in preparing a medicament for treating ascites due to cirrhosis relates to a novel application of the scutellaria baicalensis. The invention aims at providing a novel application of the scutellaria baicalensis, and particularly relates to the application of the scutellaria baicalensis in a medicament for treating ascites due to cirrhosis, a medicament for treating liver function damage, a medicament for treating hepatic fibrosis, a medicament for treating liver tissue damage, a medicament for treating hypoproteinemia and a medicament or treating cholestasis. Compared with a modern therapy method, the application of the scutellaria baicalensis has the advantage that the complications, such as hepatic encephalopathy, renal function damage, hyponatremia, hypokalemia or hyperkalemia and the like are avoided, also has the advantages of low treatment cost, simple use method, ideal treatment effect and the like and is conductive to clinical practical application. The scutellaria baicalensis is used for treating ascites due to cirrhosis.

Description

technical field [0001] The present invention relates to a new application of Scutellaria baicalensis. Background technique [0002] Cirrhotic ascites is one of the important signs of liver cirrhosis entering the decompensated stage, and it is the most common symptom among the major complications of liver cirrhosis. Once ascites occurs, the mortality rate reaches 50% within 2 years, and liver transplantation should be considered. 85% of ascites is caused by liver cirrhosis, and the remaining causes include malignant tumor (10%), cardiac insufficiency (3%), tuberculosis (2%), pancreatitis (1%) and so on. The International Ascites Association (Internationalascitesclub) divides ascites into uncomplicated ascites (uncomplicated ascites) and refractory ascites (refractory ascites). Among them, refractory ascites includes diuretic-resistant ascites (dietary sodium restriction 90mmol / d, equivalent to less than 5.2g of salt, and intensive diuretic treatment of spironolactone 400mg / ...

AI Technical Summary

Problems solved by technology

However, there are certain contraindications and side effects. For example, aldosterone receptor antagonists (spironolactone) have anti-androgen effects and side effects of hyperkalemia. Furosemide often causes severe electrolyte disturbance and metabolic alkalosis. Excessive diuretics Insufficient intravascular volume (25%) can lead to renal impairment, hepatic encephalopathy (26%), and hyponatremia (28%), and diuretics are ineffective and resistant; circulatory function is affected after therapeutic paracentesis, The severity of its insufficiency is related to the survival rate; transjugular intrahepatic portosystemic shunt (TIPS) can cause about 25% of the incidence of hepatic encephalopathy (more common in those over 60 years old), and Child-Pugh C patients after TIPS Poor prognosis, and increase the preload of the heart, which can induce heart failure in those with heart disease

The above treatment methods all fail to achieve the desired therapeutic effect. Therefore, finding and developing a method for treating liver cirrhosis ascites with small side effects and stable therapeutic effect has become an urgent problem to be solved at present.

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