The invention provides a drug for treating chronic hepatitis B, liver cirrhosis and liver ascites, and the drug is prepared by the following pharmaceutical raw materials: tuber fleeceflower root, Chinese angelica, Szechuan lovage rhizome, white paeony root, largehead atractylodes rhizome, golden thread, dried rehmannia root, radix rehmanniae preparata, chicken's gizzard-membrane, medicated leaven, rhizome, fortune eupatorium herb, fragrant solomonseal rhizome, yanhusuo, platycodon root, Chinese gentian, costustoot, green tangerine peel, semen nelumbinis, barbary wolfberry fruit, plantain seed, chrysanthemum, Chinese thorowax root, Chinese date, coastal glehnia root, liquoric root and baical skullcap root. The various ingredients in the drug have reasonable compatibility, commonly play theeffects of invigorating spleen, replenishing qi, activating qi, easing depression, regulating qi-flowing for relieving pain, nourishing liver, dispersing stagnated liver qi, nourishing yin, supplementing blood, nourishing blood and invigorating spleen and kidney, treat both manifestation and root causes of the diseases and have good efficacy for the hepatitis B, the liver cirrhosis and the liver ascites, and the diseases can be radically cured by taking the drug according to the treatment course.