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A kind of zedoary oil injection and preparation method thereof

A technology of zedoary oil and injection, applied in the direction of medical formula, medical preparations containing active ingredients, medical preparations with non-active ingredients, etc., to achieve high clinical medicinal safety and high clinical drug safety effects

Active Publication Date: 2019-11-08
张蕊 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The patent application with application number 201310394141.1 discloses a kind of zedoary oil injection and its preparation method. zedoary oil injection made of zedoary ester (HS15 for short) as a solubilizer is safer than the commercially available zedoary oil injection, but as an injection, there is still room for further improvement in clarity

Method used

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  • A kind of zedoary oil injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 (specification: 10ml: 0.1g)

[0015] Take 100.0g of zedoary oil, add 1200.0g of HS15, and stir evenly; take an appropriate amount of water for injection at 30°C to 40°C, add slowly, stir while adding, and stir evenly when the volume reaches 10000.0ml; add 2.0g of activated carbon, stir evenly, and then stand still After 30 minutes, filter; use 1.0mol / L hydrochloric acid to adjust the pH value to 4.58, filter until the clarity is acceptable, and then fill and seal.

Embodiment 2

[0016] Example 2 (specification: 10ml: 0.1g)

[0017] Take 100.0g of zedoary oil, add 1500.0g of HS15, and stir evenly; take an appropriate amount of water for injection at 30°C ~ 40°C, add slowly, stir while adding, and stir evenly when the volume reaches 10000.0ml; add 2.0g of activated carbon, stir evenly, and then statically After 30 minutes, filter; use 1.0mol / L hydrochloric acid to adjust the pH value to 4.58, filter until the clarity is acceptable, and then fill and seal.

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Abstract

The invention discloses oleum curcumae injection and a preparation method thereof. According to components of the oleum curcumae injection, (1) oleum curcumae is served as an active ingredient; (2) macrogol 15-hydroxystearate which is also named as polyethylene glycol-12- hydroxystearate and is named as HS15 for short is served as a solubilizer; and (3) injection water serves as a solvent. Compared with the existing oleum curcumae injection, a product prepared by the preparation method meets pharmacopeia standards of the oleum curcumae injection, and the clarity of the product is greatly improved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a zedoary oil injection and a preparation method thereof. Background technique [0002] Zedoary oil is derived from the volatile oil extracted from the rhizomes of Zingiberaceae Curcuma and Curcuma. Modern medical research has confirmed that Zedoary oil has anti-virus, anti-bacterial, anti-tumor, anti-thrombosis, liver protection, treatment of psoriasis, cervical erosion, digestive Wide range of pharmacological activities such as ulcers and immune enhancement. Zedoary oil injection is often used clinically as an antiviral drug. From 1988 to July 2004, 221 cases of Zedoary oil injection were reported in the case report database of the National Center for Adverse Drug Reaction Monitoring. In the case reports, the age of patients is mainly concentrated in children under 10 years old, accounting for 62.4%; the main reason for medication is respiratory tract infec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/9066A61K47/14A61P31/12
Inventor 张蕊梁加莉金洪伟
Owner 张蕊
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