Externally-applied traditional Chinese medicine emulsion for prevention and treatment of knee osteoarthritis and preparation method thereof

A technology for knee osteoarthritis and traditional Chinese medicine, which is applied in the field of external use of traditional Chinese medicine emulsion for prevention and treatment of knee osteoarthritis and its preparation, can solve the problem of not being able to use massage and acupuncture in combination, and achieves the advantages of reducing drug dosage, reducing organ damage, and reducing costs. Effect

Active Publication Date: 2016-02-03
GUANGDONG SECOND PROVINCIAL TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, judging from the existing external preparations for treating knee osteo

Method used

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  • Externally-applied traditional Chinese medicine emulsion for prevention and treatment of knee osteoarthritis and preparation method thereof
  • Externally-applied traditional Chinese medicine emulsion for prevention and treatment of knee osteoarthritis and preparation method thereof
  • Externally-applied traditional Chinese medicine emulsion for prevention and treatment of knee osteoarthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prepare a traditional Chinese medicine emulsion for prevention and treatment of knee osteoarthritis according to the following steps:

[0028] (1) Take the following medicinal materials based on parts by mass: 0.42 parts of Eucommia ulmoides, 0.07 parts of Dragon's blood, 0.25 parts of Psoralen, 0.07 parts of Scorpion, 0.7 parts of Drynaria fortune and 0.7 parts of Rehmannia;

[0029] (2) Eucommia, Dragon's blood and Psoralen are extracted twice with 70% ethanol at reflux. The ratio of the volume of 70% ethanol added during each reflux extraction to the total mass of Eucommia, Dragon's blood and Psoralen is 6 volumes Parts: 1 part by mass, refluxed for 2 hours, filtered, the filtrate obtained each time is combined, ethanol is recovered and concentrated to obtain a clear paste, dried in vacuum, pulverized, and the fat-soluble solvent isopropyl myristate (IPM) is added to 100 mass Part, heated to dissolve, filtered, and used as the oil phase for later use;

[0030] (3) Decoctio...

Embodiment 2

[0033] Prepare a traditional Chinese medicine emulsion for prevention and treatment of knee osteoarthritis according to the following steps:

[0034] (1) Take the following medicinal materials based on parts by mass: 0.42 parts of Eucommia ulmoides, 0.07 parts of Dragon's blood, 0.25 parts of Psoralen, 0.07 parts of Scorpion, 0.7 parts of Drynaria fortune and 0.7 parts of Rehmannia;

[0035] (2) Eucommia, Dragon's blood and Psoralen are extracted once with 95% ethanol under reflux. The ratio of the volume of 95% ethanol added during each reflux extraction to the total mass of Eucommia, Dragon's blood and Psoralen is 12 parts by volume : 1 part by mass, refluxed for 1 hour, filtered, the filtrate obtained each time is combined, ethanol is recovered and concentrated to obtain a clear paste, vacuum dried, pulverized, add isopropyl hexadecanoate (IPP) to 50 parts by mass, and heat Dissolve, filter, and use as the oil phase for use;

[0036] (3) Decoct the medicinal residue of step (2) t...

Embodiment 3

[0039] Prepare a traditional Chinese medicine emulsion for prevention and treatment of knee osteoarthritis according to the following steps:

[0040] (1) Take the following medicinal materials based on parts by mass: 0.42 parts of Eucommia ulmoides, 0.07 parts of Dragon's blood, 0.25 parts of Psoralen, 0.07 parts of Scorpion, 0.7 parts of Drynaria fortune and 0.7 parts of Rehmannia;

[0041] (2) Crush eucommia, dragon's blood, and psoralen to the coarsest powder, add 95% ethanol as an entrainer, infiltrate for 1 hour, the ratio of the volume of entrainer to the total mass of eucommia, dragon's blood and psoralen is 2 Parts by volume: 1 part by mass, supercritical CO 2 Extraction, where the extraction process parameters are: extraction pressure 28MPa, extraction temperature 55°C, extraction time 150 minutes; recover ethanol, collect the extract, add olive oil (LCT) to 50 parts by mass, heat to dissolve, filter, and use as oil Phase, spare

[0042] (3) Decoct the medicinal residue of ...

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Abstract

The invention discloses an externally-applied traditional Chinese medicine emulsion for the prevention and treatment of knee osteoarthritis and a preparation method thereof. The externally-applied traditional Chinese medicine emulsion for the prevention and treatment of knee osteoarthritis is an O/W type dispersion, the average particle size of a dispersion phase is 0.5 micron, and the externally-applied traditional Chinese medicine emulsion is pharmaceutically named as a microemulsion preparation or a sub-nano emulsion preparation; and the externally-applied traditional Chinese medicine emulsion for the prevention and treatment of knee osteoarthritis is prepared from the following raw materials in parts by mass: 0.42 part of eucommia barks, 0.07 part of sangusis draconis, 0.25 part of fructus psoraleae, 0.07 part of buthus martensi karsch, 0.7 part of rhizoma drynariae, and 0.7 part of rehmanniae vaporata, and the content of Chinese medicinal materials in the finally prepared emulsion is 0.22%. The emulsion disclosed by the invention has the effects of nourishing liver and kidney, strengthening muscles and bones, and promoting blood circulation to remove meridian obstruction, and is suitable for treating orthopedic diseases such as limb bone arthralgia, neck, waist and leg pains and the like caused by the deficiency of liver and kidney and the stasis of tendons and vessels; and the emulsion can be applied to affected parts directly through the skin, and has a characteristic of remarkable drug effect.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a preparation method of a traditional Chinese medicine preparation for external use for preventing and treating knee osteoarthritis, in particular to a traditional Chinese medicine emulsion for external use for preventing and treating knee osteoarthritis and a preparation method thereof. Background technique [0002] Osteoarthritis is a chronic joint disease that mainly changes the degeneration of the articular cartilage surface and secondary bone hyperplasia. It represents the aging of the joints, so it is called senile arthritis. Elderly knee osteoarthritis belongs to the category of TCM Gubi, which is a common and frequently-occurring disease in orthopedics. Preliminary domestic epidemiological investigations show that the incidence rate is 30%. The main symptom is the progressively worsening knee joint pain, which seriously harms the quality of life and socia...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61K36/896A61K9/107A61P19/02A61P19/08A61P29/00A61K35/646
Inventor 许学猛
Owner GUANGDONG SECOND PROVINCIAL TRADITIONAL CHINESE MEDICINE HOSPITAL
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