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Application of Shoushen Shenbao Capsules in Preparation of Drugs for Treating Ischemic Memory Impairment

A technology of Shoushen Shenbao and memory impairment, which is applied in the field of medicine, can solve the problems that Shoushen Shenbao capsules are not involved in the treatment of ischemic memory impairment and has no related research, so as to reduce the number of mistakes in platform jumping experiments, improve the vitality of SOD and MDA content, the effect of improving the number of times the maze experiment reached the standard

Active Publication Date: 2019-04-09
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The functions and indications of Shoushen Shenbao Capsules do not involve the treatment of ischemic memory impairment, and there is no relevant research in the existing literature

Method used

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  • Application of Shoushen Shenbao Capsules in Preparation of Drugs for Treating Ischemic Memory Impairment
  • Application of Shoushen Shenbao Capsules in Preparation of Drugs for Treating Ischemic Memory Impairment

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0029] Experimental example 1, the impact on ischemic memory impairment rats

[0030] 1. Materials

[0031] 1. Animals: 96 healthy adult male SD rats, weighing 260-320 g, were selected and purchased from the Experimental Animal Center of Shandong University. After adapting to the environment for 2 days, the rats were randomly divided into 8 groups: blank group, model group, original drug group, petroleum ether group, ethyl acetate group, ethanol group, and water extraction group.

[0032] 2. Preparation of each extract

[0033] a. Petroleum ether extract: take 50 g of finely ground powder of Shoushen Shenbao Capsules, add petroleum ether with a volume-to-weight ratio of 6 times and a boiling range of 60-90° C. and boil for extraction 3 times, each time for 1 hour. Recover petroleum ether under reduced pressure at 40°C-50°C to obtain 2.01 g of petroleum ether extract.

[0034] b. Ethyl acetate extract: take the medicinal dregs extracted by petroleum ether, evaporate the petr...

Embodiment 1

[0058] Example 1. Application of Shoushen Shenbao Capsule in the preparation of medicine for treating ischemic memory impairment.

Embodiment 2

[0059] Example 2, the application of the ethyl acetate extract prepared from the medicinal materials of Shoushen Shenbao Capsules in the preparation of drugs for the treatment of ischemic memory impairment, the ethyl acetate extract is prepared as follows: take Shoushen Shenbao Capsules The medicinal material is obtained by adding 6 times the weight of ethyl acetate and boiling extraction for 3 times, each time for 1 hour, and recovering the ethyl acetate under reduced pressure at 50°C.

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Abstract

The invention discloses a gymnadenia conopsea kidney-tonifying capsule capable of improving ischemic memory disorders. Animal experiments indicate that the gymnadenia conopsea kidney-tonifying capsule and extracts thereof, especially an ethyl acetate extract, can improve the number of up-to-standard times of ischemia model rat maze experiments, reduce the number of times of step-down test errors and remarkably improve SOD activity and MDA content of cerebral ischemia model rats, and prompt that the gymnadenia conopsea kidney-tonifying capsule has the effects of improving the ischemic memory disorders.

Description

technical field [0001] The invention relates to the application of Shoushen Shenbao Capsules in the preparation of medicines for treating ischemic memory impairment, and belongs to the field of medicine. Background technique [0002] Shoushen Shenbao Capsules are recorded in the national drug standard part of the local standard increase of Chinese patent medicine, standard number: WS-10550 (ZD-0550)-2002 (referred to as "current standard"), and the prescription is as follows: 100g of hand ginseng, 100g of Polygonatum, asparagus 62.4g, Rhododendron 32g, Cordyceps 6.3g, have the effects of warming kidney and nourishing yin, replenishing essence and marrow, and are used for deficiency of kidney yang, nocturnal emission, impotence, soreness of waist and knees, dizziness and fatigue. [0003] The incidence of ischemic cerebrovascular disease accounts for more than 50% of the total incidence of all cerebrovascular diseases, and it is the main cause of memory impairment in middle-a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61K9/48A61P25/28A61P39/06
Inventor 邵成雷姬涛马宏伟王海苹孙绪丁
Owner SHANDONG JINHE DRUG RES DEV