A system for predicting the degree of liver fibrosis in patients with chronic hepatitis B virus infection with normal or mildly elevated alanine aminotransferase

A hepatitis B virus, chronic hepatitis B technology, applied in the system field of predicting the degree of liver fibrosis in chronic hepatitis B virus-infected patients with normal or slightly elevated alanine aminotransferase

Active Publication Date: 2017-02-01
PEKING UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing studies on non-invasive fibrosis diagnostic indicators or models of chronic hepatitis B are mainly limited to the cohort with elevated ALT (especially ALT≥2ULN), and few people with normal or mildly elevated ALT (ALT<2ULN) concerned

Method used

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  • A system for predicting the degree of liver fibrosis in patients with chronic hepatitis B virus infection with normal or mildly elevated alanine aminotransferase
  • A system for predicting the degree of liver fibrosis in patients with chronic hepatitis B virus infection with normal or mildly elevated alanine aminotransferase
  • A system for predicting the degree of liver fibrosis in patients with chronic hepatitis B virus infection with normal or mildly elevated alanine aminotransferase

Examples

Experimental program
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Embodiment 1

[0041] Example 1. Non-invasive model Fib-index is used to predict the degree of liver fibrosis in patients with chronic hepatitis B virus infection with normal or slightly elevated alanine aminotransferase

[0042] 1. Establishment of non-invasive model Fib-index

[0043] 1. Research object

[0044] (1) Case source: chronic hepatitis B virus infection patients from 24 centers across the country in October 2013 and September 2014. (2) Inclusion criteria: age 18-65 years old; HBsAg positive history for half a year or more. (3) Exclusion criteria: patients with chronic hepatitis C, AIDS infection, hereditary liver disease, drug liver, non-alcoholic fatty liver and other basic patients, patients with primary liver cancer, liver cirrhosis, and pregnant women. All patients signed the informed consent before enrollment.

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Abstract

The invention discloses a system for predicting a chronic hepatitis B virus infected patient liver fibrosis degree with normal or slightly increased glutamic-pyruvic transaminase. A non-invasive model Fib-index established by adopting a transforming growth factor-alpha, an interleukin-2 receptor, thrombocyte, hepatitis B antigen e and hepatitis B virus DNA as markers has diagnosis value for a chronic hepatitis B virus infected patient with ALT normal or slightly increased (less than 2ULN) and ALT greater than or equal to 2LN. The non-invasive model Fib-index can predict the liver fibrosis degree of the chronic hepatitis B virus infected patient according to the level of a cycling cell factor, is a non-invasive detection method and is expected to assist a clinical treatment decision.

Description

technical field [0001] The invention relates to a system for predicting the degree of liver fibrosis in patients with chronic hepatitis B virus infection with normal or slightly elevated alanine aminotransferase in the field of biomedicine. Background technique [0002] Alanine aminotransferase (ALT) has been widely used clinically as an important indicator for screening and monitoring liver diseases for a long time. The Asia-Pacific and American Society of Liver Diseases guidelines on chronic hepatitis B all regard the increase of ALT value more than 2 times ULN (upper limit of normal, upper limit of normal value) as one of the necessary conditions for antiviral treatment for patients with chronic hepatitis B virus infection . However, the literature shows that patients with chronic hepatitis B virus infection with normal or slightly elevated ALT (<2ULN) may also have hidden damage to the liver. If antiviral treatment is not given immediately, the disease may be delayed...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/576G01N33/68C12Q1/06C12Q1/70C12Q1/68C12R1/93
CPCC12Q1/06G01N33/5761G01N33/6869G01N33/6872
Inventor 王贵强邓永琼赵鸿李俊王艳洪源周继远
Owner PEKING UNIV FIRST HOSPITAL
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