Xiao'er Feireping capsule and preparation method thereof

A lung-heat, pediatric technology, applied in capsule delivery, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of slow disintegration, unsatisfactory curative effect, and low curative effect.

Inactive Publication Date: 2016-03-02
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of Xiaoer Feireping Capsules on the market is not ideal due to the composition and process. The preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect.

Method used

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  • Xiao'er Feireping capsule and preparation method thereof
  • Xiao'er Feireping capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 45g of patchouli, 80g of pomegranate peel, 39g of Xinyi, 3.3g of bezoar, 55g of earthworm, 9.9g of pearl, 44g of fistula, 55g of fritillaria, 0.27g of musk, 44g of coptis, 88g of scutellaria, 1g of antelope horn, 0.55 of borneol g, Lithospermum 39g, Bupleurum 55g, crushed into 60 mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 16Mpa, extraction temperature 20℃, separator pressure 12Mpa, separator temperature 37℃, separation time 2.0 hours, The carbon dioxide flow rate is 23L per hour, and the extract is obtained; the extract is dried under reduced pressure at 61°C to obtain a dry paste; the dry paste is added with 150 g of mannitol, and the mixture is pulverized into a mixed dry paste powder with a particle size of 200-300 nm using a high-energy nano impact mill; Mixed dry paste powder, microcrystalline cellulose 45g, cross-linked polyvinylpyrrolidone 45g, croscarmellose sodium 35g, mix well, wet granulation with 50% etha...

specific Embodiment 2

[0035] Take 45g of patchouli, 80g of pomegranate peel, 39g of Xinyi, 3.3g of bezoar, 55g of earthworm, 9.9g of pearl, 44g of fistula, 55g of fritillaria, 0.27g of musk, 44g of coptis, 88g of scutellaria, 1g of antelope horn, 0.55 of borneol g, Lithospermum 39g, Bupleurum 55g, crushed into 60 mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 41Mpa, extraction temperature 39℃, separator pressure 19Mpa, separator temperature 57℃, separation time 3.5 hours, The flow rate of carbon dioxide is 34L per hour to obtain the extract; take the extract and dry under reduced pressure at 77°C to obtain a dry paste; add 200g of mannitol to the dry paste and pulverize into a mixed dry paste powder with a particle size of 200-300nm using a high-energy nano-impact mill; take Mixed dry paste powder, microcrystalline cellulose 55g, cross-linked polyvinylpyrrolidone 55g, croscarmellose sodium 45g, mix well, wet granulation with 70% ethanol, dry at 80°C, add...

Embodiment 3

[0037] Take 45g of patchouli, 80g of pomegranate peel, 39g of Xinyi, 3.3g of bezoar, 55g of earthworm, 9.9g of pearl, 44g of fistula, 55g of fritillaria, 0.27g of musk, 44g of coptis, 88g of skullcap, 1g of antelope horn, 0.55 of borneol g, Lithospermum 39g, Bupleurum 55g, crushed into 60 mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 28Mpa, extraction temperature 30℃, separator pressure 15Mpa, separator temperature 47℃, separation time 3 hours, The flow rate of carbon dioxide is 28L per hour to obtain the extract; take the extract and dry under reduced pressure at 69°C to obtain a dry paste; take the dry paste and add 175g of mannitol, and use a high-energy nano-impact mill to pulverize into a mixed dry paste powder with a particle size of 200-300nm; take Mixed dry paste powder, microcrystalline cellulose 50g, cross-linked polyvinylpyrrolidone 50g, croscarmellose sodium 40g, mix well, wet granulation with 60% ethanol, dry at 70°C, ...

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Abstract

The invention discloses a Xiao'er Feireping capsule and a preparation method thereof. The preparation method is characterized by comprising the following steps: taking 45 g of pogostemon cablin, 80 g of pericarpium granati, 39 g of flos magnoliae, 3.3 g of calculus bovis, 55 g of lumbricus, 9.9 g of pearl, 44 g of polygonum bistorta, 55 g of fritillary bulb, 0.27 g of musk, 44 g of coptidis rhizome, 88 g of radix scutellariae, 1 g of cornu saigae tataricae, 0.55 g of borneol, 39 g of shikonin and 55 g of radix bupleuri; extracting by using a carbon dioxide supercritical extraction method; drying under reduced pressure; pulverizing into nano dried cream by using a high-energy nano impact mill; and adding functional auxiliary materials and preparing into the Xiao'er Feireping capsule. The disintegration time is shortened remarkably, and the curative effect is remarkably higher than that of Xiao'er Feireping capsules in markets, and the positive effect is achieved.

Description

Technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a Xiaoer Fei Reping capsule and a preparation method thereof. Background technique [0002] Pediatric Feireping Capsule to clear away heat and resolve phlegm, relieve cough and relieve asthma, relieve convulsion and resuscitation. For children with lung-heat, asthma and cough, thick yellow spit, high fever, polydipsia, dizziness, delirium, convulsions, red and yellow fur. The commercially available Xiaoerfeireping Capsules have poor curative effect due to the composition and process. The preparations are prepared by traditional techniques, which have the disadvantages of slow disintegration and low curative effect. Summary of the invention [0003] In order to overcome the above shortcomings, the present invention provides a Xiaoerfeireping capsule with fast disintegration speed and high curative effect and a preparation method thereof. [0004] The embodiments of the invent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/48A61K47/38A61P11/06A61P11/14A61K35/62A61K35/618A61K35/55A61K35/413A61K35/32A61K31/045
Inventor 不公告发明人
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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