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Arnica long-acting sustained release preparation for treating contusions and preparation method thereof

A slow-release preparation, the technology of arnica, applied in the field of preparation and its preparation, the long-acting sustained-release preparation of arnica for the treatment of contusions and its preparation, can solve the problems of inconvenient use, achieve convenient production, improve stability, Reduces the irritating effect

Inactive Publication Date: 2016-03-23
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] From the existing products and related studies, it can be found that whether it is a single arnica prescription or an arnica compound preparation, they are all conventionally released dosage forms, which require multiple doses per day, which makes it inconvenient to use

Method used

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  • Arnica long-acting sustained release preparation for treating contusions and preparation method thereof
  • Arnica long-acting sustained release preparation for treating contusions and preparation method thereof
  • Arnica long-acting sustained release preparation for treating contusions and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0047] The preparation of embodiment 1 Arnica extract

[0048] Weigh 10g of dried arnica flowers, put them in a Soxhlet extractor, the ratio of dried arnica flowers to 65% ethanol aqueous solution is 1:10, heat to 95°C-100°C, reflux for 1-1.5h, cool and filter, After repeated extraction 4 times, the filtrates were combined, concentrated and evaporated to obtain 5 mL of Arnica extract, which was set aside.

Embodiment 2

[0049] The preparation of embodiment 2 Arnica extract-ethyl cellulose microcapsule

[0050] Weigh 200.0g of ethyl cellulose, dissolve it in 2.87L of dichloromethane, and slowly add 400mL of arnica extract after it is completely dissolved. After stirring at 800 rpm for 10 min, the above solution was slowly added dropwise to 20 L of 0.1% gelatin aqueous solution at a concentration (w / v), and continued to stir at 25°C for 24 h until the dichloromethane was completely volatilized; then filtered, washed, After vacuum freeze-drying for 24 hours, 317 g of Arnica extract-ethylcellulose microcapsules was obtained.

Embodiment 3

[0051] The preparation of embodiment 3 Arnica extract-ethyl cellulose microcapsule

[0052] Weigh 200.0g of ethyl cellulose, dissolve it in 3.62L of dichloromethane, and slowly add 450mL of arnica extract after it is completely dissolved. After stirring at a speed of 1000rpm for 10min, the above solution was slowly added dropwise to 25L of 1.4% gelatin aqueous solution at a concentration (w / v), and continued to stir at 25°C for 26h until the dichloromethane was completely volatilized; then filtered, washed, After vacuum freeze-drying for 24 hours, 313 g of Arnica extract-ethylcellulose microcapsules were obtained.

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Abstract

The invention relates to an arnica long-acting sustained release preparation for treating contusions and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. By means of the arnica long-acting sustained release preparation, long-acting dosing of medicine for external use is achieved, stability of active ingredients is improved, the release time of the arnica long-acting sustained release preparation is prolonged, the dosing frequency is reduced, skin stimulation caused by inconvenience and excessive medicament of multiple times of dosing in each day is avoided, and tolerance of patients is improved to a certain degree. By means of the arnica long-acting sustained release preparation, the aim of prolonging efficacy is achieved through the specific composition ratio and the specific preparation method.

Description

technical field [0001] The invention relates to a preparation and a preparation method thereof, in particular to an arnica long-acting slow-release preparation for treating contusions and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations. Background technique [0002] Arnica belongs to Compositae herb, which is mainly distributed in North America. It contains plant essential oils and is a traditional healing herb for treating bruises and anti-blood stasis. The main active ingredients of Arnica flower extract are sesquiterpene lactones and flavonoids, which are used to treat congestion, sprains, muscle pain, rheumatism, and stimulate the immune system. Arnica extract can be used to treat musculoskeletal disorders, promote healing after local injuries, reduce abrasions and relieve muscle pain; external use can treat skin scars caused by surgery and laser treatment, 20% of Arnica extract Used topically to treat disfigur...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K9/06A61P29/00
CPCA61K9/0002A61K9/0014A61K9/06A61K9/50A61K36/28A61K47/44A61K2236/331A61K2236/333
Inventor 尚青张晓云史永利田瑞琼
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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