74 results about "Skin stimulation" patented technology

The invention discloses a skin chip, a skin model and application of the skin chip and the skin model. The material of the skin chip does not contain polydimethylsiloxane; the skin chip comprises a first chip and a second chip, wherein the first chip is used for providing a bottom accommodating space for a dermal culture medium; the dermal culture chip layer and the epidermal culture chip layer are arranged at the top end of the first chip, and the second chip is used for supplying and storing a culture medium or supplying skin irritants; wherein the skin chip adopts a gravity perfusion mode; the skin chip is detachable, and all layers of the skin chip are connected through a polyimide material or are made of the polyimide material; a culture cavity between the dermal culture chip layer and the epidermal culture chip layer is through up and down; the first chip and the second chip are not provided with electrodes, or the first chip and the second chip are respectively provided with a first electrode and a second electrode. According to the skin chip provided by the invention, the experiment flexibility is enhanced, and the cost is reduced; and a real culture environment can be simulated.

The present invention relates to a method for producing a canine atopic dermatitis animal model, a canine atopic dermatitis animal model produced thereby, and a use thereof. According to the present invention, a canine atopic dermatitis animal model is produced by skin stimulation on a dog through epicutaneous sensitization with ovalbumin at a concentration of 1 to 5 mg / ml once daily for 1 to 2 weeks and then with ovalbumin at a concentration of 1 to 5 mg / ml once daily for 2 to 8 weeks. The resulting animal model exhibits clinical symptoms of atopic dermatitis, changes in relevant factors such as increased expression levels of IgE and CCL17, and elevated expression levels of Th2-related cytokines IL-4, IL-31, and IL-13. Therefore, this invention enables the establishment of a standardized animal model for symptoms and Th2 immune responses appearing upon the onset of atopic dermatitis, and the model can be used in clinical studies for screening candidate agents for the prevention, alleviation, or treatment of atopic dermatitis.

The invention provides a non-invasive high-precision blood glucose sensor and a preparation method thereof. The blood glucose sensor comprises two symmetrical sensing areas prepared on a flexible substrate layer, each sensing area comprises a glucose sensor working electrode, a glucose sensor auxiliary electrode / reference electrode, a sodium ion sensor working electrode, a pH sensor working electrode and a sodium ion / pH sensor common reference electrode; the electrodes are distributed in an axial symmetry mode along the central axis of the sensor plane and are prepared through silk-screen printing. Due to the symmetrical structural design of the blood glucose sensor, the electrode polarity of the extraction electrode can be exchanged during two adjacent times of extraction so as to reduce electrode consumption and skin stimulation, the change of the extraction amount of intercellular fluid can be corrected by the integrated sodium ion and pH sensor, and therefore high-precision blood glucose monitoring is achieved.

A skin-stimulating device for imparting a stimulus to the skin, includes: a first film that bends when a voltage is applied; a plurality of first film-form electrodes provided on one surface of the first film so as to be separated from one another by a prescribed spacing; a second film that bends when a voltage is applied; a second film-form electrode provided on one surface of the second film; and a dielectric member molded from a dielectric rubber in the shape of a thin sheet in which a hole is opened, with other surface of the first film being affixed to a first surface that is a prescribed surface of the dielectric member, and the other surface of the second film being affixed to a second surface on the reverse side from the first surface.

The invention relates to the technical field of visual impaired people assistance, in particular to a self-adaptive perception prompting system and method for visual impaired people assistance, and the method comprises the following steps: obtaining environment data around a user; the target information is recognized and transmitted to the user through the wearable somatosensory feedback module in a skin stimulation mode, so that the user can perceive surrounding objects and directions thereof through skin stimulation, and then obstacle avoidance can be achieved. Furthermore, an active exploration self-adaptive auxiliary module is introduced, an action track of a user is collected and analyzed to be compared with an environment model, an omission area or space deviation in perception is recognized, and a reinforcing prompt is triggered, so that the user is guided to complete more comprehensive environment exploration and space construction. Limitations of a traditional blind guiding stick and a traditional blind guiding dog are avoided, and higher-precision space perception and navigation assistance can be obtained only by wearing the somatosensory feedback module.

The invention relates to the technical field of nerve stimulation, in particular to a wearable minimally invasive tibial nerve stimulation device which comprises a nerve stimulation unit, a nerve conduction interception unit, a surface-mounted minimally invasive needle electrode unit, a loop electrode unit, an auxiliary positioning and binding unit, a key unit, a display unit, a power management unit and a wireless signal transmission unit. Electrical stimulation signals are effectively transmitted to subcutaneous tissue through the wearable microneedle puncture technology, effective stimulation of tibial nerves deep in the tissue is achieved, in combination with the nerve conduction interception and plantar motion decoding technology, self-adaptive adjustment of output signals of the nerve stimulation unit is achieved, individual self-adaptive stimulation is achieved, the discomfort of percutaneous stimulation is reduced, and the application range is wide. The treatment effect is improved.

1. Name of the product in this design: Transcutaneous acupoint electrical stimulator (ear acupoint). 2. Purpose of this design: To stimulate acupoints on the ear through the skin to prevent and treat diseases. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

1. Name of the product in this design: Beauty Device. 2. Purpose of this design: It is a beauty device that can stimulate the skin through an electrically conductive part protruding from the bottom surface. 3. The key design features of this product are its overall shape. 4. The picture or photo that best illustrates the key design points: Design 1 3D diagram 1. 5. Design 1 is designated as the basic design.

The invention discloses a plaster for gout as well as a preparation method and application thereof, belongs to the technical field of medicines, and aims to solve the problems of poor moisture retention in winter, low transdermal efficiency and strong sensitive skin irritation of the existing external plaster for gout. The plaster comprises the following raw materials: a first component (10-20 parts of indigo naturalis, 20-30 parts of rhubarb and other 10 traditional Chinese medicines) and a second component (0.5-1 part of sea buckthorn fruit polysaccharide, 0.5-1 part of cynomorium songaricum polysaccharide, 2-3 parts of evening primrose oil microcapsules and the like). The preparation method comprises the steps of raw material pretreatment (extraction and crushing), component mixing and plaster forming. The first component ensures the core curative effects of clearing heat, eliminating dampness and activating meridians to stop pain, the second component synergistically solves the problems of skin dryness and transdermal penetration in winter, the modified component ensures the stability, the sensitive skin irritation rate is low, and the traditional Chinese medicine composition is suitable for patients suffering from gouty swelling and pain and skin sensitivity in winter and wide in clinical applicability.

The present invention discloses a recombinant human fibronectin with soothing composite function and its preparation method and application. The recombinant human fibronectin with soothing composite function has an amino acid sequence as shown in SEQ ID NO.1. The present invention adds the hyaluronic acid interaction segment of human fibronectin while retaining the main segment of human fibronectin cell adhesion and cell integrin receptor interaction, and connects the two domains with a flexible "linker" amino acid sequence GGS to form a recombinant human FN protein with composite function. In addition to the core characteristics of traditional recombinant fibronectin, the recombinant human fibronectin also has the function of soothing cell stimulation. The recombinant human fibronectin prepared by the present invention will have a good effect in soothing skin irritation in the field of functional active skin care products.

The female polyurethane condom comprises a condom body, a bottom elastic ring body is fixed to the bottom end of the condom body, an upper elastic ring body is arranged on the top of the interior of the condom body, and the diameter of the upper elastic ring body is smaller than that of the bottom elastic ring body; a plurality of annular protruding parts are formed on the inner side wall of the middle of the condom body. The polyurethane condom is made of polyurethane, the condom body with the thin wall face can be manufactured, the annular protruding part of the polyurethane condom can promote the touch feeling of the male genital organ and the outer wall face of the male genital organ after the male genital organ enters the condom, skin irritation is improved, and the using effect is improved.

To provide an anti-inflammatory composition containing cholesterol.SOLUTION: According to one form, provided is an anti-inflammatory composition containing cholesterol as an active ingredient. In some forms, the anti-inflammatory composition inhibits epidermal inflammation. In some forms, the anti-inflammatory composition suppresses inflammation induced by light irradiation or skin stimulation. In another form, provided is a production inhibitor for at least one inflammatory cytokine selected from IL-1α, IL-1β, IL-6, and TNFα, containing cholesterol.SELECTED DRAWING: None

The present invention relates to a smart diaper having an improved structure, which minimizes skin problems of a wearer, increases an electrical connection force with a detection line of the diaper when a sensing device is mounted on the diaper, and minimizes a foreign body sensation or discomfort of the wearer when the sensing device is mounted on the diaper.

The utility model relates to the technical field of laser welding, and discloses a power battery clamp-free laser welding device which comprises an operation table, the bottom face of the operation table is fixedly connected with a supporting frame, and the surface of the supporting frame is fixedly connected with an air draft assembly. According to the clamp-free laser welding device for the power battery, through the arrangement of the air draft assembly and the filtering assembly, when the clamp-free laser welding device for the power battery is used, an external power source is connected, an air draft fan is started, and smoke generated by laser welding of the power battery is collected through a smoke suction hood and reaches a filtering frame through an exhaust pipe; the activated carbon in the filter frame adsorbs harmful gas and tiny particles which may be contained in the smoke, so that the smoke is collected and filtered, the smoke and the gas have potential harm to human health, the symptoms such as respiratory tract stimulation, cough, sore throat, asthma, eye and skin stimulation and the like which may be caused by inhalation of the smoke and the gas are avoided, and the health care effect is achieved. And potential harm of laser welding to a human body is reduced.

The invention relates to application of extracellular vesicles in antibacterial yoga clothes, the application comprises that the extracellular vesicles are micro-fixed on the surface layer of yoga clothes fabric through a padding method or a spraying method, and the problems that chemical antibacterial agents (silver ions, graphene and the like) of existing yoga clothes are high in cost and large in skin irritation, and environment / health risks exist are solved. The extracellular vesicles are slightly fixed on the surface layer of the yoga clothes fabric through a padding method or a spraying method, and the extracellular vesicles can inhibit biological membranes formed by pathogenic bacteria such as staphylococcus aureus and escherichia coli on the surface layer of the yoga clothes fabric by interfering pathogenic bacteria quorum sensing. The fabric has the advantages that peculiar smell substances such as sulfides and fatty acid volatile substances generated by metabolism of bacteria in a sweat wet environment are reduced from the source, fabric peculiar smell control is achieved, compared with chemical antibacterial agents such as silver ions and graphene, biotoxicity risks and environmental accumulation hidden dangers are avoided, anaphylactic reactions caused by long-term contact between yoga clothes and skin can be remarkably reduced, and wearing safety is improved.

The present invention relates to a skin-stimulating patch capable of autonomously contracting, and more particularly, to a skin-stimulating patch comprising a contractile material and a trigger material. According to one embodiment of the present invention, it is possible to provide a patch for skin stimulation, which is a patch capable of stimulating skin, and which comprises: a contractile material that can contract under a preset condition; and the triggering material is used for applying preset energy to the contractile material so that the condition can be met.

1. Name of the product in this design: Skin Beauty Device. 2. Purpose of this design: It is a beauty device that can stimulate the skin through an electrically conductive part protruding from the bottom surface. 3. The key design features of this product are its overall shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present invention relates to a beauty device. The beauty device identifies information regarding a cartridge that contains a cosmetic product and is inserted into the device, so as to automatically provide various skin-stimulation functions.

The invention provides a method and a device for measuring and calculating idiopathic hand tremor and skin electrical stimulation equipment thereof. The measuring and calculating method comprises the following steps: acquiring a hand tremor signal and storing the hand tremor signal; and after the acquisition is completed, carrying out feature analysis on the hand vibration signal to obtain a hand vibration frequency, namely a measurement result, and then carrying out signal conversion on the hand vibration frequency. According to the method for measuring and calculating the idiopathic hand tremor, hand tremor data collection and data analysis can be achieved by holding the mobile device, and the measurement and calculation of the idiopathic hand tremor are achieved by fully utilizing a built-in sensor and a built-in communication interface of the mobile device such as a smart phone in the prior art.

Compositions, systems, and methods for reducing electrical induction and / or skin irritation caused by application of an alternating electric field to the skin of a subject are disclosed. The compositions, systems, and methods involve administering to a subject at least one composition comprising at least one local anesthetic, and then applying an alternating electric field to the subject.

1. The name of the design product: transdermal acupoint electrical stimulation instrument. 2. The use of the design product: for stimulating acupoints of the head through the skin to achieve the purpose of preventing and treating diseases. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The special danger warning device for the deaf based on skin stimulation, using a microphone, receives warnings and vital sounds and sends them to a microcontroller with Bluetooth and Wi-Fi for differentiation and classification. After comparing the received data with the information defined in the claimed invention, the microcontroller sends a signal to activate the vibration motor, and the vibration motor creates a vibration on the skin and informs the deaf person. In situations where there is a possibility of a change in the body's vital signs, the claimed invention has the ability to detect and issue an alert by generating vibrations on the skin and also to the claimed invention application via Bluetooth. In situations such as gassing that causes an increase in the amount of carbon monoxide gas, it has the ability to detect the amount of gas and generate an alert by inducing vibrations on the skin. Considering the safety challenges of the deaf, including the risk of getting lost and the inability to get help from others, and other disorders such as sleepwalking, the claimed invention is capable of monitoring the individual and sending the real-time location to the application via Bluetooth.

1. The name of the design product: ear stimulator. 2. The use of the design product: is a accessory of transdermal acupoint electrical stimulation instrument, used for stimulating ear acupoint through the skin, to achieve the purpose of preventing and treating diseases. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: design 1 perspective view 1. 5. Design 1 is designated as the basic design.

A skin stimulation device that applies mechanical stimulation to skin, has an actuator element having an electroded body, and a first electrode and a second electrode provided to the electroded body, which is displaced in accordance with a drive voltage applied to the first electrode and the second electrode, and a film-like base material that is wearable to the skin, which is provided with the actuator element and is stretchable and contractible, and an element array in which a plurality of the actuator elements are connected in a column along a surface of the base material is formed.

The invention discloses an adhesion-drug release collaborative design system and method of adhesion type hydrogel, which are applied to the field of biomedical materials. A gradient cross-linking density and dynamic dual-network synergistic adhesion mechanism, a pH responsive nanopore channel of a drug sustained-release layer and a molecularly imprinted chain segment synergistic controlled-release mechanism, and a micro-breathable structure of a bionic cuticle barrier membrane and a zwitter-ion anti-adhesion surface synergistic protection mechanism are constructed; collaborative optimization of triple properties of adhesion self-enhancement in a wet environment, intelligent drug release and low skin irritation is realized; the method does not depend on traditional single function layer stacking or static parameter regulation and control, and starts from three dimensions of material microstructure design, interface coupling relation construction and dynamic response mechanism implantation to establish a set of multi-level collaborative design process capable of being implemented in an engineering mode. The finally formed hydrogel application product can maintain stable adhesive force in a complex physiological environment, at the same time releases treatment components as required, and reduces interference to a skin barrier function to the maximum extent.

The present disclosure provides a slit blade block and an electric razor capable of more efficiently shaving body hair while suppressing stimulation to skin. The slit blade block according to the present disclosure includes a slit outer blade having a plurality of outer blade pieces extending in a first direction and spaced apart from each other along a second direction intersecting the first direction. The slit blade block further includes a comb component comprising a plurality of combs that are disposed outside the slit outer blade in the first direction and spaced apart from each other along the second direction. The comb component comprises a protrusion protruding outward in the first direction, and the protrusion includes a first protrusion extending across two or more of combs disposed side by side in the second direction.

1. The name of the design product: transdermal acupoint electrical stimulation instrument (cranium ear). 2. The use of the design product: for stimulating ear acupoints through the skin to achieve the purpose of preventing and treating diseases. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention provides a construction method of an atopic dermatitis animal model, and the construction method comprises the step of carrying out sensitization treatment on a TSLP transgenic mouse by adopting local skin stimulation and a mixed sensitization source so as to construct the atopic dermatitis animal model. In the technical scheme, the TSLP transgenic mouse is induced and sensitized by adopting local skin stimulation and a mixed sensitization source, and the skin of the mouse specifically expresses the TSLP, so that the skin inflammation can quickly appear and is similar to the human AD symptom. Compared with a common mouse-induced allergy animal model, the method has the advantages of high sensitization efficiency, obvious sensitization effect and the like, can be applied to experimental research on AD diseases, and provides a research model for clinical research on AD diseases.

The present disclosure provides a dermal stimulation device and methods of use thereof. The dermal stimulation device comprises a removable head piece and an elongate base member. The elongate base member comprises a proximal portion comprising one or more conducting surfaces, a circumferential rim configured for engaging with the removable head piece, and an actuatable element configured to actuate one or more electrical components housed within the elongate handle. The removable head piece comprises a plurality of light emitting elements and a distal flange configured for engaging with the circumferential rim of the elongate base member, wherein engaging elongate base member with the removable head piece causes the elongate base member to be in electrical communication with the removable head piece.

Embodiments of the present invention provide a cosmetic applicator apparatus for a cosmetic eye applicator. The cosmetic applicator apparatus comprising a shell and at least one stimulation element configured to stimulate the skin. A liquid outlet channel runs through the shell, connecting to the bottle body. At the shell's output end, there are two distinct surfaces: an application surface and a stimulation surface, positioned on opposite sides. The application surface and the stimulation surface are oriented at intersecting angles, with the liquid outlet located on the application surface, and the stimulation component is placed near the stimulation surface. This structural arrangement ensures that the functions of liquid application and skin stimulation remain independent, preventing interference between the two.