Small intestinal mucosal sub -dharma supplement and preparation methods and applications
A small intestinal submucosa and patch technology, applied in medical science, prosthesis, etc., can solve the problems of short half-life, poor stability, and high requirements, and achieve strong bone regeneration ability, wide application prospects, and reliable composite materials.
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Embodiment 1
[0024] The small intestinal submucosa drug-loaded patch of Example 1, its microstructure includes SIS collagen fiber skeleton and icariin loaded on the SIS collagen fiber skeleton, the SIS collagen fiber skeleton is a reticular fiber structure, and icariin is a particle shape (grain size is 0.3~0.6μm), icariin is attached to the SIS collagen fiber skeleton, and the adhesion amount of icariin is 33.2±5.6μg / cm 2 , its preparation method comprises the following steps:
[0025] 1) Preparation of the small intestinal submucosa patch: In a sterile environment, take out the dry and sterile SIS material, cut it into a small intestinal submucosa patch of 1 cm × 1 cm, and then wash the cut small intestinal submucosa patch with deionized water. Immerse for 12-24 hours to fully wet the material, discard the deionized water and soak with 50% ethanol solution for 1-2 hours, then replace with 70%, 80%, 90% ethanol solution and absolute ethanol in sequence after discarding the ethanol solutio...
Embodiment 2
[0028] The small intestinal submucosa drug-loaded patch of Example 2, its microstructure includes SIS collagen fiber skeleton and icariin loaded on the SIS collagen fiber skeleton, the SIS collagen fiber skeleton is a reticular fiber structure, and icariin is a particle shape (particle size: 0.3-5μm), icariin is attached to the SIS collagen fiber skeleton, and the adhesion amount of icariin is 56.2±8.8μg / cm 2 , its preparation method comprises the following steps:
[0029] 1) Preparation of the small intestinal submucosa patch: In a sterile environment, take out the dry and sterile SIS material, cut it into a small intestinal submucosa patch of 1 cm × 1 cm, and then wash the cut small intestinal submucosa patch with deionized water. Immerse for 12-24 hours to fully wet the material, discard the deionized water and soak with 50% ethanol solution for 1-2 hours, then replace with 70%, 80%, 90% ethanol solution and absolute ethanol in sequence after discarding the ethanol solution...
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