Ginkgo flavone and lactone composition, dripping pill thereof, and application of dripping pill

A technology of ginkgo ketone ester and composition, which is applied in the field of ginkgo ketone ester composition and its dripping pills, can solve bleeding and other problems, and achieve the effect of improving bleeding problems

Active Publication Date: 2016-03-30
李宏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the bleeding problem caused by the long-term use of ginkgo ketone ester in the prior art, the embodiment of the present invention provides a ginkgo ketone ester composition and its dripping pills and application

Method used

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  • Ginkgo flavone and lactone composition, dripping pill thereof, and application of dripping pill
  • Ginkgo flavone and lactone composition, dripping pill thereof, and application of dripping pill
  • Ginkgo flavone and lactone composition, dripping pill thereof, and application of dripping pill

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0016] 1. Preparation of Panax notoginseng

[0017] Xie Guoxiang (Separation, purification and structure analysis of Panax notoginseng, Natural Product Research and Development, 2007,19:1059-1061), Tan Chaoyang (Study on the separation and purification of the active ingredients of Panax notoginseng, Herald of Traditional Chinese Medicine, 2010,16( 1): 63-65), Zhang Yuping (Extraction, separation and content determination of notoginseng in Panax notoginseng, Shanxi Traditional Chinese Medicine, 2009, 25(10): 55-56) and others studied and reported the extraction and separation of notoginseng Methods, using the method reported in the literature, extraction and isolation of notoginseng. The dry powder of notoginseng was slowly infiltrated with 12 times the amount of 70% ethanol, the residue was soaked in an appropriate amount of distilled water for 24 hours, and ultrasonically extracted with 10 times the amount of distilled water for 3 times, each time for 1 hour, to obtain a wate...

experiment example 1、 10

[0026] Experimental example 1, the effect of notoginseng phospholipid complex on coagulation time

[0027] 80 healthy Kunming mice (body weight 20g±2g), half male and half female, were fed for one week according to normal requirements, and divided into 8 groups, namely the low-dose notoginseng group, the middle-dose notoginseng group, and the high-dose notoginseng group group, low-dose notoginseng-phospholipid complex group, middle-dose notoginseng-phospholipid complex group, high-dose notoginseng-phospholipid complex group, blank control group, and phenetamine group. Each group was given the corresponding drug, administered once a day, and the blank control group was given the same volume of distilled water for 3 consecutive days. One hour after the last administration, blood was collected from the eye socket with a capillary tube with a diameter of 0.5 mm, and timed by a stopwatch. Break the capillary every 10 seconds until thin blood streaks appear, and record the coagulati...

experiment example 2

[0033] Experimental example 2, pharmacological effect of ginkgo ketone ester notoginseng composition on hyperlipidemia

[0034] 270 healthy SD rats (body weight 200g±20g), half male and half male, were fed for one week according to normal requirements, and the normal values ​​of serum TC and TG were measured. Among them, 240 SD rats were given high-fat diet (79% basal diet, 1% cholesterol, 10% egg yolk powder, 10% lard) for 10 consecutive days to induce hyperlipidemia. The other 30 rats continued to be fed according to normal requirements, as the normal group. 240 SD rats with hyperlipidemia were randomly divided into 8 groups, 30 in each group, respectively hyperlipidemia model group, ginkgo ketone ester notoginseng composition group (1:0.8), ginkgo ketone ester notoginseng combination group Ginkgo ketone ester notoginseng composition group (1:0.4), ginkgo ketone ester notoginseng composition group (1:0.2), ginkgo ketone ester notoginseng composition group (1:0.1), ginkgo ke...

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Abstract

The invention provides a ginkgo flavone and lactone composition, a dripping pill thereof, and an application of the dripping pill. The effective drug effect components of the composition comprise ginkgo flavone and lactone and dencichine, the composition is prepared through mixing ginkgo flavone and lactone with dencichine according to a ratio of 1:0.1-1:0.2. The ginkgo flavone and lactone composition and the dripping pill thereof can effectively improve the hemorrhage problem induced by long-term use of ginkgo flavone and lactone.

Description

technical field [0001] The invention relates to a ginkgo ketone ester composition, dropping pills and application thereof. Background technique [0002] Ginkgo biloba, sweet, bitter, astringent, flat in nature; promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, astringing the lungs to relieve asthma, transforming turbidity and lowering lipids; used for blood stasis blocking collaterals, chest pain and heartache, stroke hemiplegia, lung deficiency cough and asthma, Hyperlipidemia; the history of medicinal use in my country has been about 3000 years. In the 1960s, German scientists discovered that Ginkgo biloba contains effective ingredients for lowering cholesterol, which led to the research and development of Ginkgo biloba's pharmacological effects. Ginkgo ketone ester is the only second-class new drug (effective part) approved by the State Food and Drug Administration among the ginkgo extracts. The approval number: Z20000049 has ...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K9/20A61K47/24A61P9/10A61P9/12A61P11/06A61P3/10A61P25/28A61K31/198
CPCA61K9/2031A61K31/198A61K36/16A61K47/24A61K2300/00
Inventor 麻军法李传俊陈应林于自勋岳昌林范玲玲田宏迪
Owner 李宏
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