A boron neutron capture therapy dose measurement method

Abstract

The invention discloses a boron neutron capture therapy dose measuring method. The boron neutron capture therapy dose measuring method comprises: according to the difference of Cherenkov light intensity distribution per unit volume before injection of medicament containing boron and during the boron neutron capture therapy process, determining concentration distribution of the medicament containing boron in real time; and at the same time, according to the Cherenkov light intensity distribution per unit volume during the boron neutron capture therapy process, obtaining the Gamma total dose distribution, and finally obtaining the boron neutron capture therapy dose distribution according to the proportional relation between various doses which are generated because of reaction between thermal / epithermal neutron and different components. The boron neutron capture therapy dose measuring method has the advantages of being able to judge concentration distribution of the medicament containing boron, being high in real time online property and being simple in measurement, and can effectively guarantee the curative effect of boron neutron capture therapy and radiation safety for a patient.

Description

technical field [0001] The invention belongs to the field of radiotherapy, and in particular relates to a method for real-time measurement of radiation dose of boron neutron capture therapy. technical background [0002] Boron neutron capture therapy (BNCT) uses thermal neutrons to capture α particles and 7 Li particles kill tumor cells, which has the advantage of highly selective killing of tumor cells at the cellular level, and is an ideal method for treating malignant tumors in principle. However, at present, BNCT is still in the stage of clinical trials and has not been able to implement "routine" treatment. The reason is that the key core technologies have not yet been perfectly resolved. Real-time and accurate dose measurement is the core technology for BNCT treatment quality assurance and control, to ensure the efficacy of radiotherapy, and to ensure the radiation protection and safety of patients. However, due to many factors such as complex neutron beam energy spe...

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Problems solved by technology

However, due to many factors such as complex neutron beam energy spectrum, individual differences in patients, concentration changes of boron in the metabolic process of the human body, and uneven distribution of boron-loaded drugs in tumor tissues and cells, the BNCT dose Real-time measurement has always been a technical bottleneck in BNCT technology that is difficult to solve perfectly

[0003] At present, there is not a sufficiently "ideal" real-time measurement method of BNCT dose at home and abroad, especially it cannot satisfy: 1) real-time online measurement during radiotherapy in vivo; 2) consideration of real-time boron-containing drug concentration distribution factors in vivo

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