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Sepsis biomarkers and uses thereof

A biomarker, sepsis technology, applied in sepsis biomarkers and their application fields, can solve problems such as failure to identify pathogenic organisms, attempts to complicate, and aggravate disease

Inactive Publication Date: 2016-04-06
睿智研究实验室私人有限公司
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AI Technical Summary

Problems solved by technology

In about one-third of sepsis patients, the causative organism cannot be identified, further hindering the early implementation of antimicrobial therapy or even exacerbating the disease. The extensive use of broad-spectrum antibiotics has led to resistance to antimicrobial drugs
[0006] Previous studies identifying sepsis biomarkers such as cytokines, chemokines, acute phase proteins, soluble receptors, and cell surface markers have not been able to reliably distinguish between infectious and noninfectious causes of inflammation
Obtaining precise biomarkers for sepsis diagnosis is difficult because host responses to SIRS and infection are regulated by multiple pathways, complicating attempts to obtain precise biomarkers

Method used

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  • Sepsis biomarkers and uses thereof
  • Sepsis biomarkers and uses thereof
  • Sepsis biomarkers and uses thereof

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Embodiment Construction

[0083] The present invention uses a polygenic marker approach as a diagnostic biomarker derived from a gene expression profile in leukocytes isolated from a subject's blood sample, which provides a significantly more accurate and faster diagnostic method than existing methods. Advantageously, gene expression profiling overcomes, or at least reduces, the problem of delayed diagnosis of sepsis since up- or down-regulation of genes occurs prior to synthesis of functional gene products such as pro-inflammatory proteins. Advantageously, the present invention can reliably and accurately classify individuals with sepsis, or provide prognostic clues to the progression of the syndrome, allowing more effective therapeutic intervention.

[0084] Conduct a cohort study. The objectives of the cohort study on patients with sepsis in the emergency department include: (i) obtaining and confirming gene expression panels differentially expressed in leukocytes of patients with and without sepsis...

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Abstract

Worldwide incidence rate of sepsis continues to rise, with increasing concern in the elderly patients due to fast aging population. There is a need for effective biomarkers for diagnosis and / or prognosis of sepsis. The present invention relates to diagnostic and / or prognostic biomarker or biomarkers for detection and / or prediction of sepsis. The present invention discloses a predetermined panel of genes which are biomarkers for detection and / or prognosis of sepsis in a subject, including the states or conditions in the sepsis continuum.

Description

technical field [0001] The present invention relates to the detection and / or prediction of diagnostic and / or prognostic biomarkers for sepsis. Background technique [0002] The following description about the background of the present invention is to facilitate the understanding of the present invention. However, it should be understood that the discussion is not an admission that any of the material referenced was published, known or part of the common general knowledge in any jurisdiction as at the priority date of the application. [0003] Sepsis is the host's response to infection by bacteria or other infectious agents, such as viruses, fungi, or parasites. This response is called systemic inflammatory response syndrome (SIRS). The outcome of sepsis is determined by the virulence of the invading pathogen and the host response, which can be an overgrowth, leading to collateral damage to organs and tissues. Typically, when sepsis occurs, the host's body is unable to deg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor S·H·王W·S·管D·吴
Owner 睿智研究实验室私人有限公司
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